Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Warren, C.A.; van Opstal, E.; Ballard, T.E.; Kennedy, A.; Wang, X.; Riggins, M.; Olekhnovich, I.; Warthan, M.; Kolling, G.L.; Guerrant, R.L.; Macdonald, T.L.; Hoffman, P.S.
    Amixicile, a novel inhibitor of pyruvate ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model (2012), Antimicrob. Agents Chemother., 56, 4103-4111 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.7.1 nitazoxanide 52% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
1.2.7.1 VPC161183 36% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
1.2.7.1 VPC161195 56% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
1.2.7.1 VPC161219 61% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
1.2.7.1 VPC162096
-
 Clostridioides difficile
1.2.7.1 VPC162125 71% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
1.2.7.1 VPC162134 75% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
1.2.7.1 VPC16a1011 34% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
1.2.7.1 VPC16b1094 66% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
1.2.7.1 VPC16b2031 84% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.7.1 pyruvate + CoA + oxidized ferredoxin Clostridioides difficile
-
 acetyl-CoA + CO2 + reduced ferredoxin + H+
-
 ?
1.2.7.1 pyruvate + CoA + oxidized ferredoxin Clostridioides difficile ATCC 43255
-
 acetyl-CoA + CO2 + reduced ferredoxin + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.7.1 Clostridioides difficile
-
-
-
1.2.7.1 Clostridioides difficile ATCC 43255
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.7.1 pyruvate + CoA + oxidized benzyl viologen
-
 Clostridioides difficile acetyl-CoA + CO2 + reduced benzyl viologen + H+
-
 ?
1.2.7.1 pyruvate + CoA + oxidized benzyl viologen
-
 Clostridioides difficile ATCC 43255 acetyl-CoA + CO2 + reduced benzyl viologen + H+
-
 ?
1.2.7.1 pyruvate + CoA + oxidized ferredoxin
-
 Clostridioides difficile acetyl-CoA + CO2 + reduced ferredoxin + H+
-
 ?
1.2.7.1 pyruvate + CoA + oxidized ferredoxin
-
 Clostridioides difficile ATCC 43255 acetyl-CoA + CO2 + reduced ferredoxin + H+
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.2.7.1 0.008
-
 25°C, pH 7.4 Clostridioides difficile VPC162134
1.2.7.1 0.024
-
 25°C, pH 7.4 Clostridioides difficile nitazoxanide