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Literature summary extracted from

  • Thakur, R.; Panda, A.; Coessens, E.; Raj, N.; Yadav, S.; Balakrishnan, S.; Zhang, Q.; Georgiev, P.; Basak, B.; Pasricha, R.; Wakelam, M.; Ktistakis, N.; Raghu, P.
    Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling (2016), eLife, 5, e18515 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Drosophila melanogaster
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 photoreceptor cell
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 Drosophila melanogaster
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General Information

EC Number General Information Comment Organism
3.1.4.4 physiological function photoreceptors contain a light-dependent phospholipase D activity. During illumination, loss of PLD results in an enhanced reduction in rhabdomere size, accumulation of Rab7 positive, rhodopsin1-containing vesicles in the cell body and reduced rhodopsin protein, associated with reduced levels of phosphatidic acid. In wild-type photoreceptors, during illumination, enhanced PLD activity is sufficient to clear rhodopsin1-containing vesicles from the cell body by a process dependent on Arf1-GTP levels and retromer complex function Drosophila melanogaster