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Literature summary extracted from

  • Zemankova, K.; Makoveichuk, E.; Vlasakova, Z.; Olivecrona, G.; Kovar, J.
    Acute alcohol consumption downregulates lipoprotein lipase activity in vivo (2015), Metab. Clin. Exp., 64, 1592-1596 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.34 angiopoietin-like protein 3 ANGPTL3 inhibits the enzyme. The concentrations of inhibitor ANGPTL3 drops to 67% of baseline value at 280 min after alcohol consumption Homo sapiens
3.1.1.34 angiopoietin-like protein 4 ANGPTL4 inhibits the enzyme. The concentrations of inhibitor ANGPTL4 drops to 86% of baseline value at 280 min after alcohol consumption Homo sapiens
3.1.1.34 ethanol inhibits the enzyme, LPL activity is reduced by 23-25% 2-4 hours after the administration of alcohol, respectively, with respect to controls, in vivo or in post-heparin plasma. The concentrations of inhibitors ANGPTL3 and ANGPTL4 drops to 67% and 86% of baseline values, respectively, at 280 min after alcohol consumption. The acute effects of alcohol consumption, especially on postprandial lipemia, seem to be accentuated in hypertriglyceridemic subjects Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.34 triacylglycerol + H2O Homo sapiens
-
diacylglycerol + a carboxylate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.34 Homo sapiens P06858
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.34 blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.34 triacylglycerol + H2O
-
Homo sapiens diacylglycerol + a carboxylate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.34 LPL
-
Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.1.34 physiological function the enzyme is the key enzyme responsible for intravascular triglyceride lipolysis. The acute alcohol consumption can induce hypertriglyceridemia, partly by influencing of lipoprotein lipase (LPL) through alcohol. LPL is the key enzyme responsible for triglyceride hydrolysis in circulation. The acute effects of alcohol consumption, especially on postprandial lipemia, seem to be accentuated in hypertriglyceridemic subjects Homo sapiens