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Literature summary extracted from

  • Hannibal, L.; Kim, J.; Brasch, N.E.; Wang, S.; Rosenblatt, D.S.; Banerjee, R.; Jacobsen, D.W.
    Processing of alkylcobalamins in mammalian cells A role for the MMACHC (cblC) gene product (2009), Mol. Genet. Metab., 97, 260-266 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.151 an alkylcobalamin + [alkylcobalamin reductase] + glutathione Homo sapiens the CblC protein is responsible for alkylcobalamins dealkylation in mammalian cells cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione
-
 ?
2.5.1.151 an alkylcobalamin + [alkylcobalamin reductase] + glutathione Bos taurus the CblC protein is responsible for alkylcobalamins dealkylation in mammalian cells cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.151 Bos taurus Q5E9C8
-
-
2.5.1.151 Homo sapiens Q9Y4U1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.151
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.151 aortic endothelial cell
-
 Bos taurus
-
2.5.1.151 skin fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.151 5'-deoxyadenosylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Homo sapiens cob(I)alamin-[alkylcobalamin reductase] + S-5'-deoxyadenosylglutathione
-
 ?
2.5.1.151 5'-deoxyadenosylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Bos taurus cob(I)alamin-[alkylcobalamin reductase] + S-5'-deoxyadenosylglutathione
-
 ?
2.5.1.151 an alkylcobalamin + [alkylcobalamin reductase] + glutathione the CblC protein is responsible for alkylcobalamins dealkylation in mammalian cells Homo sapiens cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione
-
 ?
2.5.1.151 an alkylcobalamin + [alkylcobalamin reductase] + glutathione the CblC protein is responsible for alkylcobalamins dealkylation in mammalian cells Bos taurus cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione
-
 ?
2.5.1.151 butyrylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Homo sapiens cob(I)alamin-[alkylcobalamin reductase] + S-butyrylglutathione
-
 ?
2.5.1.151 butyrylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Bos taurus cob(I)alamin-[alkylcobalamin reductase] + S-butyrylglutathione
-
 ?
2.5.1.151 ethylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Homo sapiens cob(I)alamin-[alkylcobalamin reductase] + S-ethylglutathione
-
 ?
2.5.1.151 ethylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Bos taurus cob(I)alamin-[alkylcobalamin reductase] + S-ethylglutathione
-
 ?
2.5.1.151 hexylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Homo sapiens cob(I)alamin-[alkylcobalamin reductase] + S-hexylglutathione
-
 ?
2.5.1.151 hexylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Bos taurus cob(I)alamin-[alkylcobalamin reductase] + S-hexylglutathione
-
 ?
2.5.1.151 methylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Homo sapiens cob(I)alamin-[alkylcobalamin reductase] + S-methylglutathione
-
 ?
2.5.1.151 methylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Bos taurus cob(I)alamin-[alkylcobalamin reductase] + S-methylglutathione
-
 ?
2.5.1.151 pentylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Homo sapiens cob(I)alamin-[alkylcobalamin reductase] + S-pentylglutathione
-
 ?
2.5.1.151 pentylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Bos taurus cob(I)alamin-[alkylcobalamin reductase] + S-pentylglutathione
-
 ?
2.5.1.151 propylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Homo sapiens cob(I)alamin-[alkylcobalamin reductase] + S-propyglutathione
-
 ?
2.5.1.151 propylcobalamin + [alkylcobalamin reductase] + glutathione
-
 Bos taurus cob(I)alamin-[alkylcobalamin reductase] + S-propyglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.151 cblC
-
 Homo sapiens
2.5.1.151 cblC
-
 Bos taurus
2.5.1.151 MMACHC
-
 Homo sapiens
2.5.1.151 MMACHC
-
 Bos taurus