Literature summary extracted from
Hu, J.; Guo, L.; Wu, K.; Liu, B.; Lang, S.; Huang, L.
Template-dependent polymerization across discontinuous templates by the heterodimeric primase from the hyperthermophilic archaeon Sulfolobus solfataricus (2012), Nucleic Acids Res., 40, 3470-3483 .
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.7.7.102 |
Saccharolobus solfataricus |
Q97Z83 and Q9UWW1 |
Q97Z83 i.e. small subunit PriS, Q9UWW1 i.e. large subunit PriL |
- |
2.7.7.102 |
Saccharolobus solfataricus DSM 16170 |
Q97Z83 and Q9UWW1 |
Q97Z83 i.e. small subunit PriS, Q9UWW1 i.e. large subunit PriL |
- |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
2.7.7.102 |
SSO0557 |
large subunit |
Saccharolobus solfataricus |
2.7.7.102 |
SSO1048 |
small subunit |
Saccharolobus solfataricus |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
2.7.7.102 |
physiological function |
the enzyme is able to synthesize products far longer than templates in vitro. The long products result from template-dependent polymerization across discontinuous templates, which is initiated through either primer synthesis or terminal transfer, and occurs efficiently on templates containing contiguous dCs. The enzyme is able to promote strand annealing. PriSL catalyzes template-dependent polymerization across discontinuous templates with either dNTPs or rNTPs as the substrates but prefers the latter |
Saccharolobus solfataricus |