EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.34 | triacylglycerol + H2O | Mus musculus | - |
diacylglycerol + a carboxylate | - |
? | |
3.1.1.34 | triacylglycerol + H2O | Mus musculus BALB/c | - |
diacylglycerol + a carboxylate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.34 | Mus musculus | P11152 | - |
- |
3.1.1.34 | Mus musculus BALB/c | P11152 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.34 | cardiac muscle | - |
Mus musculus | - |
3.1.1.34 | heart | - |
Mus musculus | - |
3.1.1.34 | skeletal muscle | - |
Mus musculus | - |
3.1.1.34 | white adipose tissue | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.34 | triacylglycerol + H2O | - |
Mus musculus | diacylglycerol + a carboxylate | - |
? | |
3.1.1.34 | triacylglycerol + H2O | - |
Mus musculus BALB/c | diacylglycerol + a carboxylate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.34 | LPL | - |
Mus musculus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
3.1.1.34 | Mus musculus | lipasin suppresses the activity of LPL specifically in cardiac and skeletal muscles | down |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.1.34 | physiological function | lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase. Lipasin/Angptl8 is a feeding-induced hepatokine that regulates triglyceride (TAG) metabolism. Lipasin-deficient mice exhibit elevated postprandial activity of LPL in the heart and skeletal muscle, but not in white adipose tissue, suggesting that lipasin suppresses the activity of LPL specifically in cardiac and skeletal muscles. During fasting, LPL activity is upregulated in the heart and skeletal muscle, which, in turn, take up fatty acids for energy production. In the fed state, LPL activity is upregulated in white adipose tissue, which, in turn, takes up fatty acids for storage | Mus musculus |