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Literature summary extracted from

  • Colmenares, S.U.; Swenson, J.M.; Langley, S.3.; Kennedy, C.; Costes, S.V.; Karpen, G.H.
    Drosophila histone demethylase KDM4A has enzymatic and non-enzymatic roles in controlling heterochromatin integrity (2017), Dev. Cell, 42, 156-169 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.B19 nucleus KDM4A predominantly localizes to heterochromatin and regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair Drosophila melanogaster 5634
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1.14.11.65 nucleus KDM4A predominantly localizes to heterochromatin and regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair Drosophila melanogaster 5634
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Organism

EC Number Organism UniProt Comment Textmining
1.14.11.B19 Drosophila melanogaster Q9V333
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1.14.11.65 Drosophila melanogaster Q9V333
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.B19 [histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
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 Drosophila melanogaster [histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.B19 [histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
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 Drosophila melanogaster [histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
-
 ?
1.14.11.B19 [histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
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 Drosophila melanogaster [histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
-
 ?

General Information

EC Number General Information Comment Organism
1.14.11.B19 physiological function KDM4A regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair. KDM4A demethylase activity is dispensable for position-effect variegation. KDM4A enzymatic activity is required to relocate heterochromatic double-strand breaks outside the domain, and for organismal survival when DNA repair is compromised. DNA damage triggers KDM4A-dependent changes in the levels of H3K56me3. In heterochromatin, KDM4A loss alters H3K9me3 but not H3K36me3 levels and KDM4A is required for demethylation of H3K56me3 during DNA damage Drosophila melanogaster
1.14.11.65 physiological function KDM4A regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair. KDM4A demethylase activity is dispensable for position-effect variegation. KDM4A enzymatic activity is required to relocate heterochromatic double-strand breaks outside the domain, and for organismal survival when DNA repair is compromised. DNA damage triggers KDM4A-dependent changes in the levels of H3K56me3. In heterochromatin, KDM4A loss alters H3K9me3 but not H3K36me3 levels and KDM4A is required for demethylation of H3K56me3 during DNA damage Drosophila melanogaster