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Literature summary extracted from

  • Wangensteen, R.; Segarra, A.B.; Ramirez-Sanchez, M.; Gasparo, M.D.; Dominguez, G.; Banegas, I.; Vargas, F.; Vives, F.; Prieto, I.
    Influence of thyroid disorders on the kidney expression and plasma activity of aminopeptidase A (2015), Endocr. Regul., 49, 68-72 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.7 angiotensin II + H2O Rattus norvegicus
-
 angiotensin III + L-Asp
-
 ?
3.4.11.7 angiotensin II + H2O Rattus norvegicus Wistar
-
 angiotensin III + L-Asp
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.7 Rattus norvegicus P15684
-
-
3.4.11.7 Rattus norvegicus Wistar P15684
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.7 blood plasma while hyperthyroid rats exhibit lower levels of plasma AP A activity than controls, the kidney of hyperthyroid animals expresses significantly higher AP A than controls and hypothyroid animals. A discrepancy between the high expression of AP A in kidney of hyperthyroid rats and the low activity of AP A measured in plasma and kidney of hyperthyroid animals is found. The posttranslational influence of environmental biochemical factors may be in part responsible for that divergence Rattus norvegicus
-
3.4.11.7 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.7 angiotensin II + H2O
-
 Rattus norvegicus angiotensin III + L-Asp
-
 ?
3.4.11.7 angiotensin II + H2O
-
 Rattus norvegicus Wistar angiotensin III + L-Asp
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.7 aminopeptidase A
-
 Rattus norvegicus
3.4.11.7 AP A
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.11.7 malfunction influence of thyroid disorders on the kidney expression and plasma activity of aminopeptidase A. In plasma, hyperthyroid rats demonstrate slight but significantly lower levels of AP A than euthyroid (control) rats Rattus norvegicus
3.4.11.7 metabolism thyroid disorders affect blood pressure and renal function through changes in the components of the local renin-angiotensin system such as aminopeptidase A (AP A or GluAP), which metabolizes angiotensin II (Ang II) to angiotensin III (Ang III), consequently regulating their functions Rattus norvegicus