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Literature summary extracted from

  • Nakamura, T.; Yamazato, M.; Ishida, A.; Ohya, Y.
    Excess of aminopeptidase A in the brain elevates blood pressure via the angiotensin II type 1 and bradykinin B2 receptors without dipsogenic effect (2017), Int. J. Hypertens., 2017, 3967595 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.7 (S)-3-amino-4-mercapto-butyl sulfonic acid i.e. EC33 Rattus norvegicus
3.4.11.7 RB150
-
Rattus norvegicus
3.4.11.7 telmisartan
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.7 cytoplasm
-
Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.7 angiotensin II + H2O Rattus norvegicus
-
angiotensin III + L-Asp
-
?
3.4.11.7 angiotensin II + H2O Rattus norvegicus Wistar-Kyoto
-
angiotensin III + L-Asp
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.7 Rattus norvegicus P15684
-
-
3.4.11.7 Rattus norvegicus Wistar-Kyoto P15684
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.7 brain immunoreactivity of APA in the medulla oblongata, the rostral ventrolateral medulla, and ambiguous nucleus Rattus norvegicus
-
3.4.11.7 heart
-
Rattus norvegicus
-
3.4.11.7 medulla oblongata
-
Rattus norvegicus
-
3.4.11.7 neuron
-
Rattus norvegicus
-
3.4.11.7 neutrophil
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.7 angiotensin II + H2O
-
Rattus norvegicus angiotensin III + L-Asp
-
?
3.4.11.7 angiotensin II + H2O
-
Rattus norvegicus Wistar-Kyoto angiotensin III + L-Asp
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.7 aminopeptidase A
-
Rattus norvegicus
3.4.11.7 APA
-
Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.11.7 malfunction excess of aminopeptidase A in the brain elevates blood pressure via the angiotensin II type 1 and bradykinin B2 receptors without dipsogenic effect Rattus norvegicus
3.4.11.7 physiological function aminopeptidase A (APA) is an enzyme that hydrolyzes the N-terminal amino acid of peptides, it is expressed in both periphery and brain. Peripheral APA is reported to have the potency to act as both protective and harmful agent on cardiovascular disease. Brain APA contributes to neurogenic hypertension. Conversion of Ang II to Ang III by APA may require elevated blood pressure in the brain. An increase in brain APA elevates the blood pressure via enzymatic activity in a dose-dependent manner. The increase in brain APA does not evoke drinking behavior. AT1 and B2 receptors contribute to the pressor response to brain APA. Increased brain APA activity evokes a pressor response via the AT1 and B2 receptors without dipsogenic effect Rattus norvegicus