EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.11.7 | (S)-3-amino-4-mercapto-butyl sulfonic acid | i.e. EC33 | Rattus norvegicus | |
3.4.11.7 | RB150 | - |
Rattus norvegicus | |
3.4.11.7 | telmisartan | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.11.7 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.11.7 | angiotensin II + H2O | Rattus norvegicus | - |
angiotensin III + L-Asp | - |
? | |
3.4.11.7 | angiotensin II + H2O | Rattus norvegicus Wistar-Kyoto | - |
angiotensin III + L-Asp | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.11.7 | Rattus norvegicus | P15684 | - |
- |
3.4.11.7 | Rattus norvegicus Wistar-Kyoto | P15684 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.11.7 | brain | immunoreactivity of APA in the medulla oblongata, the rostral ventrolateral medulla, and ambiguous nucleus | Rattus norvegicus | - |
3.4.11.7 | heart | - |
Rattus norvegicus | - |
3.4.11.7 | medulla oblongata | - |
Rattus norvegicus | - |
3.4.11.7 | neuron | - |
Rattus norvegicus | - |
3.4.11.7 | neutrophil | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.11.7 | angiotensin II + H2O | - |
Rattus norvegicus | angiotensin III + L-Asp | - |
? | |
3.4.11.7 | angiotensin II + H2O | - |
Rattus norvegicus Wistar-Kyoto | angiotensin III + L-Asp | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.11.7 | aminopeptidase A | - |
Rattus norvegicus |
3.4.11.7 | APA | - |
Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.11.7 | malfunction | excess of aminopeptidase A in the brain elevates blood pressure via the angiotensin II type 1 and bradykinin B2 receptors without dipsogenic effect | Rattus norvegicus |
3.4.11.7 | physiological function | aminopeptidase A (APA) is an enzyme that hydrolyzes the N-terminal amino acid of peptides, it is expressed in both periphery and brain. Peripheral APA is reported to have the potency to act as both protective and harmful agent on cardiovascular disease. Brain APA contributes to neurogenic hypertension. Conversion of Ang II to Ang III by APA may require elevated blood pressure in the brain. An increase in brain APA elevates the blood pressure via enzymatic activity in a dose-dependent manner. The increase in brain APA does not evoke drinking behavior. AT1 and B2 receptors contribute to the pressor response to brain APA. Increased brain APA activity evokes a pressor response via the AT1 and B2 receptors without dipsogenic effect | Rattus norvegicus |