Literature summary extracted from

Vieira, V.; Cardoso, M.; Araujo, H.
Calpain A controls mitotic synchrony in the Drosophila blastoderm embryo (2017), Mech. Dev., 144, 141-149 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.B36	Drosophila melanogaster	Q11002	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.B36	blastoderm	-	Drosophila melanogaster	-
3.4.22.B36	embryo	-	Drosophila melanogaster	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.22.B36	calpain-A	-	Drosophila melanogaster

General Information

EC Number	General Information	Comment	Organism
3.4.22.B36	physiological function	a significant percentage of embryos from hypomorphic or knockdown calpain A mothers are lethal and do not complete embryogenesis. Lethality is increased as maternal calpain A function is reduced. Impaired Calpain A function results in loss of mitotic synchrony and ultimately halted embryonic development. Calpain A is required for the metaphase-to-anaphase transition, loss leads to presence of defective microtubules and chromosomal architecture at the mitotic spindle during metaphase and anaphase and perturbed levels of Cyclin B	Drosophila melanogaster

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Release 2023.1 (January 2023)