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Literature summary extracted from

  • Larschan, E.; Alekseyenko, A.A.; Gortchakov, A.A.; Peng, S.; Li, B.; Yang, P.; Workman, J.L.; Park, P.J.; Kuroda, M.I.
    MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism (2007), Mol. Cell, 28, 121-133 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.359 3 S-adenosyl-L-methionine + [histone H3]-L-lysine36 Drosophila melanogaster overall reaction 3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
2.1.1.359 S-adenosyl-L-methionine + [histone H3]-L-lysine36 Drosophila melanogaster
-
 S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine36
-
 ?
2.1.1.359 S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine36 Drosophila melanogaster
-
 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
2.1.1.359 S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine36 Drosophila melanogaster
-
 S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.359 Drosophila melanogaster Q9VYD1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.359 larva
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.359 3 S-adenosyl-L-methionine + [histone H3]-L-lysine36 overall reaction Drosophila melanogaster 3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
2.1.1.359 S-adenosyl-L-methionine + [histone H3]-L-lysine36
-
 Drosophila melanogaster S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine36
-
 ?
2.1.1.359 S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine36
-
 Drosophila melanogaster S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
2.1.1.359 S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine36
-
 Drosophila melanogaster S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.359 CG1716
-
 Drosophila melanogaster
2.1.1.359 H3K36me3 methyltransferase
-
 Drosophila melanogaster
2.1.1.359 SET2
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.1.1.359 physiological function the enzyme is required for viability and methylation of [histone H3]-L-lysine36 in Drosophila melanogaster Drosophila melanogaster