EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
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EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.69 | [histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2 | Drosophila melanogaster | - |
[histone H3]-N6-methyllysine36 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
1.14.11.69 | [histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2 | Drosophila melanogaster | - |
[histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2 | - |
? | |
1.14.11.69 | [histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2 | Drosophila melanogaster | - |
[histone H3]-N6-methyllysine36 + succinate + formaldehyde + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.11.69 | Drosophila melanogaster | Q9V333 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.69 | [histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2 | - |
Drosophila melanogaster | [histone H3]-N6-methyllysine36 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
1.14.11.69 | [histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | [histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2 | - |
? | |
1.14.11.69 | [histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | [histone H3]-N6-methyllysine36 + succinate + formaldehyde + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.11.69 | KDM4A, | - |
Drosophila melanogaster |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.11.69 | physiological function | KDM4A specifically demethylates H3K36me2 and me3 both in vitro and in vivo. Heterochromatin Protein 1a (HP1a) associates with KDMA4A. The chromoshadow domain of HP1a and a HP1-interacting motif of KDM4A are responsible for this interaction. HP1a stimulates the histone H3K36 demethylation activity of dKDM4A. Loss of HP1a leads to increased level of histone H3K36me3 | Drosophila melanogaster |