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Literature summary extracted from

  • Drees, L.; Koenigsmann, T.; Jaspers, M.H.J.; Pflanz, R.; Riedel, D.; Schuh, R.
    Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis (2019), PLoS Genet., 15, e1007882 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B6 Drosophila melanogaster Q9W2C8
-
-
3.4.21.109 Drosophila melanogaster A1Z7M3 isoform A
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.B6 proteolytic modification the zymogen in vitro is activated by notopleural Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B6 dumpy + H2O i.e. a zona pellucida-domain protein Drosophila melanogaster ?
-
 ?
3.4.21.109 dumpy + H2O i.e. a zona pellucida-domain protein Drosophila melanogaster ?
-
 ?
3.4.21.109 tracheal-prostasin zymogen + H2O
-
 Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B6 LD47230p
-
 Drosophila melanogaster
3.4.21.B6 tracheal-prostasin
-
 Drosophila melanogaster
3.4.21.109 notopleural
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
3.4.21.B6 physiological function tracheal-prostasin is a functional homologue of prostasin. Tracheal-prostasin degrades the zona pellucida-domain protein Dumpy, a component of the transient tracheal apical extracellular matrix. The tracheal-prostasin zymogen in vitro is activated by notopleural. RNAi-mediated knockdown embryos lack tracheal liquid clearance and die during the first instar larval stage Drosophila melanogaster
3.4.21.109 physiological function notopleural is a functional homologue of matriptase. Notopleural mediates morphogeneisis and remodeling of apical extracellular matrix during tracheal system development and is essential for maintenance of the transepithelial barrier function. Notopleural degrades the zona pellucida-domain protein Dumpy, a component of the transient tracheal apical extracellular matrix. Notopleural cleaves tracheal-prostasin zymogen and the zona pellucida-domain of the extracellular matrix protein Piopio in vitro Drosophila melanogaster