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Literature summary extracted from

  • Tain, L.S.; Jain, C.; Nespital, T.; Froehlich, J.; Hinze, Y.; Groenke, S.; Partridge, L.
    Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production (2019), Aging Cell, 19, e13043 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.20 Drosophila melanogaster Q9VG42
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2.1.1.20 Mus musculus Q9QXF8
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.20 liver
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 Mus musculus
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General Information

EC Number General Information Comment Organism
2.1.1.20 physiological function in the liver of liver-specific IRS1 KO mice, expression of GNMT is increased Mus musculus
2.1.1.20 physiological function reduced insulin/IGF signaling activity modulates methionine metabolism, through tissue-specific regulation of glycine N-methyltransferase Gnmt. This regulation is required for full insulin/IGF signaling-mediated longevity. Fat body-specific expression of Gnmt is sufficient to extend lifespan. Reducing insulin/IGF signaling activity leads to a Gnmt-dependent increase in spermidine levels. Both spermidine treatment and reduced insulin/IGF signaling activity are sufficient to extend the lifespan of Drosophila, but only in the presence of Gnmt Drosophila melanogaster