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Literature summary extracted from

  • Yang, D.; Roh, S.; Jeong, S.
    The axon guidance function of Rap1 small GTPase is independent of PlexA RasGAP activity in Drosophila (2016), Dev. Biol., 418, 258-267 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.5.2 PlexA plexins (Plexs) comprise a large family of cell surface receptors for semaphorins (Semas) that function as evolutionarily conserved guidance molecules. Rap GTPase but not Ras GTPase homologs are inactivated by the GAP activity of several vertebrate plexins. GTPase activating protein (GAP) activity for Ras family small GTPases has been implicated in plexin signaling cascades through its RasGAP domain. Neuronal expression of mutant PlexA robustly restores defasciculation defects in PlexA null mutants when the catalytic arginine fingers of the PlexA RasGAP domain critical for GAP activity are disrupted. Deleting the RasGAP domain abolishes the ability of PlexA to rescue the PlexA guidance phenotypes. PlexA-mediated motor axon guidance is dependent on the presence of the PlexA RasGAP domain, but not on its GAP activity toward Ras family small GTPases Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.5.2 GTP + H2O Drosophila melanogaster
-
 GDP + phosphate
-
 ?
3.6.5.2 GTP + H2O Drosophila melanogaster w1118
-
 GDP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.2 Drosophila melanogaster P08645
-
-
3.6.5.2 Drosophila melanogaster w1118 P08645
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.5.2 nerve
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.2 GTP + H2O
-
 Drosophila melanogaster GDP + phosphate
-
 ?
3.6.5.2 GTP + H2O
-
 Drosophila melanogaster w1118 GDP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.5.2 Rap GTPase
-
 Drosophila melanogaster
3.6.5.2 Rap1
-
 Drosophila melanogaster
3.6.5.2 small GTPase
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
3.6.5.2 evolution Drosophila Rap1 is a member of the Ras family of GTPases Drosophila melanogaster
3.6.5.2 malfunction gain-of-function studies using dominant-negative and constitutively active forms of Rap1 indicate that Rap1 contributes to axonal growth and guidance Drosophila melanogaster
3.6.5.2 physiological function small GTPase Rap1 plays an important role controlling intersegmental nerve b motor axon guidance during neural development. Rap1 contributes to axonal growth and guidance. Genetic interaction analyses demonstrate that the Sema-1a/PlexA-mediated repulsive guidance function is regulated positively by Rap1. The axon guidance function of Rap1 small GTPase is independent of PlexA Ras GAP activity in Drosophila melanogaster. PlexA-mediated motor axon guidance is dependent on the presence of the PlexA RasGAP domain, but not on its GAP activity toward Ras family small GTPases Drosophila melanogaster