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Literature summary extracted from

  • Li, B.; Wang, X.; Tai, L.; Ma, T.; Shalmani, A.; Liu, W.; Li, W.; Chen, K.
    NAD kinases Metabolic targets controlling redox co-enzymes and reducing power partitioning in plant stress and development (2018), Front. Plant Sci., 9, 379 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.23 0.022
-
NAD+ pH and temperature not specified in the publication Homo sapiens
2.7.1.23 0.042
-
NADH pH and temperature not specified in the publication Arabidopsis thaliana
2.7.1.23 0.062
-
ATP pH and temperature not specified in the publication Arabidopsis thaliana
2.7.1.23 0.212
-
NAD+ pH and temperature not specified in the publication Strongylocentrotus purpuratus
2.7.1.23 0.263
-
ATP pH and temperature not specified in the publication Strongylocentrotus purpuratus
2.7.1.23 0.397
-
ATP pH and temperature not specified in the publication Strongylocentrotus purpuratus
2.7.1.23 0.4
-
ATP pH and temperature not specified in the publication Pyrococcus horikoshii
2.7.1.23 0.43
-
ATP pH and temperature not specified in the publication Sphingomonas sp.
2.7.1.23 0.43
-
NAD+ pH and temperature not specified in the publication Arabidopsis thaliana
2.7.1.23 0.52
-
NAD+ pH and temperature not specified in the publication Arabidopsis thaliana
2.7.1.23 0.54
-
NAD+ pH and temperature not specified in the publication Homo sapiens
2.7.1.23 0.54
-
NAD+ pH and temperature not specified in the publication Strongylocentrotus purpuratus
2.7.1.23 0.73
-
ATP pH and temperature not specified in the publication Arabidopsis thaliana
2.7.1.23 0.74
-
ATP pH and temperature not specified in the publication Arabidopsis thaliana
2.7.1.23 1
-
NAD+ pH and temperature not specified in the publication Bacillus subtilis
2.7.1.23 1.7
-
ATP pH and temperature not specified in the publication Homo sapiens
2.7.1.23 1.92
-
ATP pH and temperature not specified in the publication Sphingomonas sp.
2.7.1.23 2
-
ATP pH and temperature not specified in the publication Escherichia coli
2.7.1.23 2.39
-
NAD+ pH and temperature not specified in the publication Arabidopsis thaliana
2.7.1.23 2.5
-
NAD+ pH and temperature not specified in the publication Escherichia coli
2.7.1.23 3.3
-
ATP pH and temperature not specified in the publication Homo sapiens
2.7.1.86 0.17
-
ATP pH and temperature not specified in the publication Saccharomyces cerevisiae
2.7.1.86 2
-
NADH pH and temperature not specified in the publication Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.23 chloroplast
-
Arabidopsis thaliana 9507
-
2.7.1.23 cytosol
-
Homo sapiens 5829
-
2.7.1.23 cytosol
-
Arabidopsis thaliana 5829
-
2.7.1.23 cytosol
-
Glycine max 5829
-
2.7.1.23 cytosol
-
Strongylocentrotus purpuratus 5829
-
2.7.1.23 mitochondrion
-
Homo sapiens 5739
-
2.7.1.86 cytosol
-
Saccharomyces cerevisiae 5829
-
2.7.1.86 mitochondrial matrix
-
Saccharomyces cerevisiae 5759
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.23 30000
-
subunit Escherichia coli
2.7.1.23 35000
-
subunit Arabidopsis thaliana
2.7.1.23 37000
-
subunit Pyrococcus horikoshii
2.7.1.23 58200
-
subunit Arabidopsis thaliana
2.7.1.23 60000
-
subunit Strongylocentrotus purpuratus
2.7.1.23 109200
-
subunit Arabidopsis thaliana
2.7.1.86 60000
-
subunit Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.23 ATP + NAD+ Homo sapiens
-
ADP + NADP+
-
?
2.7.1.23 ATP + NAD+ Arabidopsis thaliana
-
ADP + NADP+
-
?
2.7.1.23 ATP + NAD+ Pyrococcus horikoshii
-
ADP + NADP+
-
?
2.7.1.23 ATP + NAD+ Escherichia coli
-
ADP + NADP+
-
?
2.7.1.23 ATP + NAD+ Archaeoglobus fulgidus
-
ADP + NADP+
-
?
2.7.1.23 ATP + NAD+ Strongylocentrotus purpuratus
-
ADP + NADP+
-
?
2.7.1.23 ATP + NAD+ Sphingomonas sp.
-
ADP + NADP+
-
?
2.7.1.23 ATP + NAD+ Bacillus subtilis
-
ADP + NADP+
-
?
2.7.1.23 ATP + NAD+ Escherichia coli K12
-
ADP + NADP+
-
?
2.7.1.23 ATP + NAD+ Pyrococcus horikoshii ATCC 700860
-
ADP + NADP+
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.23 Arabidopsis thaliana Q500Y9
-
-
2.7.1.23 Arabidopsis thaliana Q56YN3
-
-
2.7.1.23 Arabidopsis thaliana Q9C5W3
-
-
2.7.1.23 Archaeoglobus fulgidus P0A7B3
-
-
2.7.1.23 Bacillus subtilis M4KX93 XF-1
-
2.7.1.23 Escherichia coli P0A7B3
-
-
2.7.1.23 Escherichia coli K12 P0A7B3
-
-
2.7.1.23 Glycine max I1KAE3
-
-
2.7.1.23 Glycine max I1LPA7
-
-
2.7.1.23 Glycine max I1LVA5
-
-
2.7.1.23 Glycine max K7LNT1
-
-
2.7.1.23 Glycine max K7LY64
-
-
2.7.1.23 Homo sapiens O95544
-
-
2.7.1.23 Homo sapiens Q4G0N4
-
-
2.7.1.23 Pyrococcus horikoshii O58801
-
-
2.7.1.23 Pyrococcus horikoshii ATCC 700860 O58801
-
-
2.7.1.23 Solanum lycopersicum A0A3Q7E928
-
-
2.7.1.23 Solanum lycopersicum A0A3Q7JHB9
-
-
2.7.1.23 Sphingomonas sp. O58801
-
-
2.7.1.23 Strongylocentrotus purpuratus C3RSF7
-
-
2.7.1.23 Strongylocentrotus purpuratus P21373
-
-
2.7.1.86 Saccharomyces cerevisiae P32622
-
-
2.7.1.86 Saccharomyces cerevisiae Q06892
-
-
2.7.1.86 Saccharomyces cerevisiae ATCC 204508 P32622
-
-
2.7.1.86 Saccharomyces cerevisiae ATCC 204508 Q06892
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.23 flower low expression Arabidopsis thaliana
-
2.7.1.23 flower low expression Glycine max
-
2.7.1.23 flower moderate expression Arabidopsis thaliana
-
2.7.1.23 flower moderate expression Solanum lycopersicum
-
2.7.1.23 flower moderate expression Glycine max
-
2.7.1.23 inflorescence low expression Arabidopsis thaliana
-
2.7.1.23 inflorescence low expression Glycine max
-
2.7.1.23 inflorescence moderate expression Arabidopsis thaliana
-
2.7.1.23 inflorescence moderate expression Glycine max
-
2.7.1.23 leaf high expression Arabidopsis thaliana
-
2.7.1.23 leaf low expression Arabidopsis thaliana
-
2.7.1.23 leaf low expression Solanum lycopersicum
-
2.7.1.23 leaf low expression Glycine max
-
2.7.1.23 leaf moderate expression Glycine max
-
2.7.1.23 root high expression Glycine max
-
2.7.1.23 root low expression Glycine max
-
2.7.1.23 root moderate expression Arabidopsis thaliana
-
2.7.1.23 root moderate expression Solanum lycopersicum
-
2.7.1.23 root moderate expression Glycine max
-
2.7.1.23 seed low expression Arabidopsis thaliana
-
2.7.1.23 seed low expression Solanum lycopersicum
-
2.7.1.23 seed low expression Glycine max
-
2.7.1.23 seed moderate expression Arabidopsis thaliana
-
2.7.1.23 seed moderate expression Glycine max
-
2.7.1.23 seedling high expression Glycine max
-
2.7.1.23 seedling low expression Arabidopsis thaliana
-
2.7.1.23 seedling low expression Solanum lycopersicum
-
2.7.1.23 seedling low expression Glycine max
-
2.7.1.23 seedling moderate expression Arabidopsis thaliana
-
2.7.1.23 seedling moderate expression Glycine max
-
2.7.1.23 stem high expression Arabidopsis thaliana
-
2.7.1.23 stem low expression Arabidopsis thaliana
-
2.7.1.23 stem low expression Solanum lycopersicum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.23 ATP + NAD+
-
Homo sapiens ADP + NADP+
-
?
2.7.1.23 ATP + NAD+
-
Arabidopsis thaliana ADP + NADP+
-
?
2.7.1.23 ATP + NAD+
-
Pyrococcus horikoshii ADP + NADP+
-
?
2.7.1.23 ATP + NAD+
-
Escherichia coli ADP + NADP+
-
?
2.7.1.23 ATP + NAD+
-
Archaeoglobus fulgidus ADP + NADP+
-
?
2.7.1.23 ATP + NAD+
-
Strongylocentrotus purpuratus ADP + NADP+
-
?
2.7.1.23 ATP + NAD+
-
Sphingomonas sp. ADP + NADP+
-
?
2.7.1.23 ATP + NAD+
-
Bacillus subtilis ADP + NADP+
-
?
2.7.1.23 ATP + NAD+
-
Escherichia coli K12 ADP + NADP+
-
?
2.7.1.23 ATP + NAD+
-
Pyrococcus horikoshii ATCC 700860 ADP + NADP+
-
?
2.7.1.23 ATP + NADH
-
Arabidopsis thaliana ADP + NADPH
-
?
2.7.1.23 CTP + NAD+
-
Arabidopsis thaliana CDP + NADP+
-
?
2.7.1.23 GTP + NAD+
-
Arabidopsis thaliana GDP + NADP+
-
?
2.7.1.23 UTP + NAD+
-
Arabidopsis thaliana UDP + NADP+
-
?
2.7.1.86 ATP + NADH
-
Saccharomyces cerevisiae ADP + NADPH
-
?
2.7.1.86 ATP + NADH
-
Saccharomyces cerevisiae ATCC 204508 ADP + NADPH
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.23 ? 1 * 60000 Strongylocentrotus purpuratus
2.7.1.23 ? x * 35000 Arabidopsis thaliana
2.7.1.23 ? x * 109200 Arabidopsis thaliana
2.7.1.23 ? x * 58200 Arabidopsis thaliana
2.7.1.23 dimer 2 * 30000 Bacillus subtilis
2.7.1.23 dimer or tetramer Archaeoglobus fulgidus
2.7.1.23 hexamer 6 * 30000 Escherichia coli
2.7.1.23 homodimer 2 * 45000 Homo sapiens
2.7.1.23 homotetramer 4 * 49000 Homo sapiens
2.7.1.23 tetramer 2 * 32000 Sphingomonas sp.
2.7.1.23 tetramer 4 * 37000 Pyrococcus horikoshii
2.7.1.23 tetramer or dimer Archaeoglobus fulgidus
2.7.1.86 ? 1 * 60000 Saccharomyces cerevisiae
2.7.1.86 homooctamer 8 * 60000 Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.7.1.23 Afnk
-
Archaeoglobus fulgidus
2.7.1.23 AtNADK1
-
Arabidopsis thaliana
2.7.1.23 AtNADK2
-
Arabidopsis thaliana
2.7.1.23 AtNADK3
-
Arabidopsis thaliana
2.7.1.23 BsNADK
-
Bacillus subtilis
2.7.1.23 C5orf33
-
Homo sapiens
2.7.1.23 GmNADK1
-
Glycine max
2.7.1.23 GmNADK2
-
Glycine max
2.7.1.23 GmNADK3
-
Glycine max
2.7.1.23 GmNADK4
-
Glycine max
2.7.1.23 GmNADK5
-
Glycine max
2.7.1.23 NADK
-
Homo sapiens
2.7.1.23 NADK
-
Sphingomonas sp.
2.7.1.23 NADK2
-
Homo sapiens
2.7.1.23 PH1074
-
Pyrococcus horikoshii
2.7.1.23 SlNADK1
-
Solanum lycopersicum
2.7.1.23 SlNADK2
-
Solanum lycopersicum
2.7.1.23 SpNADK1
-
Strongylocentrotus purpuratus
2.7.1.23 SpNADK2
-
Strongylocentrotus purpuratus
2.7.1.23 YfjB
-
Escherichia coli
2.7.1.23 YjbN
-
Bacillus subtilis
2.7.1.86 Pos5
-
Saccharomyces cerevisiae
2.7.1.86 YEF1
-
Saccharomyces cerevisiae

Expression

EC Number Organism Comment Expression
2.7.1.23 Glycine max low downregulation by heat stress down
2.7.1.23 Arabidopsis thaliana moderate downregulation by cold stress down
2.7.1.23 Solanum lycopersicum moderate downregulation by drought stress and heat stress down
2.7.1.23 Glycine max moderate downregulation by heat stress down
2.7.1.23 Arabidopsis thaliana high upregulation by drought strss and salt stress, low upregulatation by heat stress and cold stress up
2.7.1.23 Glycine max low upregulation by drought stress up
2.7.1.23 Arabidopsis thaliana low upregulation by salt stress, moderate upregulatation by heat stress up
2.7.1.23 Glycine max moderate upregulation by drought stress up
2.7.1.23 Glycine max moderate upregulation by drought stress and low upregulation by heat stress up
2.7.1.23 Solanum lycopersicum moderate upregulation by salt stress up