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Literature summary extracted from

  • Tzeng, T.Y.; Lee, C.H.; Chan, L.W.; Shen, C.K.
    Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1 (2007), Proc. Natl. Acad. Sci. USA, 104, 12691-12696 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.355 C1197A mutation of conserved residue within the SET domain, loss of catalytic activity Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Drosophila melanogaster Q32KD2
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.355 L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine
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 Drosophila melanogaster N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine
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 ?
2.1.1.355 additional information SETDB1 specifically methylates H3K9, but not H3K4 or H3K27. SETDB1 methylates H3 to generate K9me1, K9me2, and K9me3 in a sequential manner Drosophila melanogaster ?
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 SETDB1
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.1.1.355 physiological function Drosophila melanogaster SETDB1 is an H3K9 methyltransferase and a pleiotropic regulator of the fly's development. Drosophila mutants hypomorphic or null in SETDB1 expression lose most of the H3K9 methylation as well as HP1-binding on the fourth chromosome. Binding of painting of fourth (POF), a fourth chromosome-specific protein, and the SETDB1-controlled H3K9 methylation of this chromosome are interdependent. POF and dSETDB1 interact with each other in vivo. The deregulation of H3K9 methylation, HP1-binding, and POF-binding result in a global reduction of gene expression from the fourth chromosome but not the other chromosomes. Deficiency of dSETDB1 also upregulates the expression of HP1 Drosophila melanogaster