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Literature summary extracted from

  • de Paula, C.P.; Dos Santos, M.C.; Tairum, C.A.; Breyer, C.A.; Toledo-Silva, G.; Toyama, M.H.; Mori, G.M.; de Oliveira, M.A.
    Glutaredoxin-like protein (GLP)-a novel bacteria sulfurtransferase that protects cells against cyanide and oxidative stresses (2020), Appl. Microbiol. Biotechnol., 104, 5477-5492 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.8.1.1 C266S activity is completely abolished, similar to wild-type, mutant is able to form high molecular weight oligomers (> 600 kDa) Xylella fastidiosa
2.8.1.1 C33S about 3fold increase in sulfurtransferase activity, mutation destabilizes the quaternary structure Xylella fastidiosa

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.1 Xylella fastidiosa
-
-
-
2.8.1.1 Xylella fastidiosa 9a5c
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.1 thiosulfate + cyanide
-
 Xylella fastidiosa sulfite + thiocyanate
-
 ?
2.8.1.1 thiosulfate + cyanide
-
 Xylella fastidiosa 9a5c sulfite + thiocyanate
-
 ?
2.8.1.1 thiosulfate + dithiothreitol
-
 Xylella fastidiosa ?
-
 ?
2.8.1.1 thiosulfate + dithiothreitol
-
 Xylella fastidiosa 9a5c ?
-
 ?
2.8.1.1 thiosulfate + glutathione
-
 Xylella fastidiosa ?
-
 ?
2.8.1.1 thiosulfate + glutathione
-
 Xylella fastidiosa 9a5c ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.1.1 GLP
-
 Xylella fastidiosa
2.8.1.1 glutaredoxin-like protein
-
 Xylella fastidiosa
2.8.1.1 XF_2394
-
 Xylella fastidiosa

Cofactor

EC Number Cofactor Comment Organism Structure
2.8.1.1 Fe-S center protein contains an Fe-S cluster Xylella fastidiosa

General Information

EC Number General Information Comment Organism
2.8.1.1 physiological function GLP can detoxify cyanide and transfer inorganic sulfur to acceptor molecules in vitro. The biological activity of GLP relies on the cysteine residues in the Grx and thiosulfate sulfurtransferase/rhodanese domain (Cys33 and Cys266, respectively). Expression of GLP in Escherichia coli can protect bacteria against high concentrations of cyanide and hydrogen peroxide Xylella fastidiosa