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Literature summary extracted from

  • Hoefler, S.; Lorenz, C.; Busch, T.; Brinkkoetter, M.; Tohge, T.; Fernie, A.R.; Braun, H.P.; Hildebrandt, T.M.
    Dealing with the sulfur part of cysteine four enzymatic steps degrade l-cysteine to pyruvate and thiosulfate in Arabidopsis mitochondria (2016), Physiol. Plant., 157, 352-366 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.1.1 mitochondrion
-
 Arabidopsis thaliana 5739
-
2.8.1.2 mitochondrion
-
 Arabidopsis thaliana 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.1 Arabidopsis thaliana O64530 cf. EC 2.8.1.2
-
2.8.1.2 Arabidopsis thaliana O64530 cf. EC 2.8.1.1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.1 3-mercaptopyruvate + 2 glutathione
-
 Arabidopsis thaliana pyruvate + glutathione disulfide
-
 ?
2.8.1.1 thiosulfate + glutathione
-
 Arabidopsis thaliana sulfite + glutathione disulfide
-
 ?
2.8.1.2 3-mercaptopyruvate + 2 glutathione
-
 Arabidopsis thaliana pyruvate + glutathione disulfide
-
 ?
2.8.1.2 thiosulfate + glutathione
-
 Arabidopsis thaliana sulfite + glutathione disulfide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.1.1 AT1G79230
-
 Arabidopsis thaliana
2.8.1.2 AT1G79230
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
2.8.1.1 metabolism a mitochondrial sulfur catabolic pathway catalyzes the complete oxidation of L-cysteine to pyruvate and thiosulfate. After transamination to 3-mercaptopyruvate, the sulfhydryl group from L-cysteine is transferred to glutathione by sulfurtransferase Str1 and oxidized to sulfite by the sulfur dioxygenase Ethe1. Sulfite is then converted to thiosulfate by addition of a second persulfide group by sulfurtransferase 1. This pathway is most relevant during early embryo development and for vegetative growth under light-limiting conditions Arabidopsis thaliana
2.8.1.1 physiological function embryo development of the thiosulfate sulfurtransferase Str1/sulfur dioxygenase Ethe1 double mutant is comparable with Str1 mutant lines and severyl impaired in comparison to wild-type. Embryogenesis is severely delayed in Str1 mutants and the Ethe1/Str1 double mutant Arabidopsis thaliana
2.8.1.2 metabolism a mitochondrial sulfur catabolic pathway catalyzes the complete oxidation of L-cysteine to pyruvate and thiosulfate. After transamination to 3-mercaptopyruvate, the sulfhydryl group from L-cysteine is transferred to glutathione by sulfurtransferase Str1 and oxidized to sulfite by the sulfur dioxygenase Ethe1. Sulfite is then converted to thiosulfate by addition of a second persulfide group by sulfurtransferase 1. This pathway is most relevant during early embryo development and for vegetative growth under light-limiting conditions Arabidopsis thaliana
2.8.1.2 physiological function embryo development of the thiosulfate sulfurtransferase Str1/sulfur dioxygenase Ethe1 double mutant is comparable with Str1 mutant lines and severyl impaired in comparison to wild-type. Embryogenesis is severely delayed in Str1 mutants and the Ethe1/Str1 double mutant Arabidopsis thaliana