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Literature summary extracted from

  • Oliw, E.H.
    Polyunsaturated C18 fatty acids derivatized with Gly and Ile as an additional tool for studies of the catalytic evolution of fungal 8- and 9-dioxygenases (2018), Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1863, 1378-1387 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.60 linoleate + O2 Gaeumannomyces graminis
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 (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.60 Gaeumannomyces graminis Q9UUS2
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.60 alpha-linolenic acid + O2
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 Gaeumannomyces graminis 8(9)epoxy-10-hydroxy-(12Z,15Z)-octadecadienoate
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 ?
1.13.11.60 linoleate + O2
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 Gaeumannomyces graminis (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
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 ?
1.13.11.60 linoleate + O2 the enzyme oxidizes linoleate and the Gly conjugate rapidly to hydroperoxides at C-8 but also at C-9 and C-13 (ratio 1:0.1:0.2, respectively) and to 7,8-diol Gaeumannomyces graminis (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
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 ?
1.13.11.60 additional information the Ile and Trp conjugates of linoleate are not oxidized at C-8. The enzyme oxidizes the linoleate-Ile conjugate to 9- and 13-HODE-Ile and to 9(10)- and 12(13)epoxyalcohols. The alpha-linolenic acid-Ile conjugate is transformed to 9-, 13-, and 16-HOTrE-Ile in a ratio of 0.4:0.3:1, respectively Gaeumannomyces graminis ?
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Synonyms

EC Number Synonyms Comment Organism
1.13.11.60 8R-DOX-7,8-LDS
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 Gaeumannomyces graminis