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Literature summary extracted from

  • Kaufmann, F.; Wohlfarth, G.; Diekert, G.
    O-Demethylase from Acetobacterium dehalogenans Substrate specificity and function of the participating proteins (1998), Eur. J. Biochem., 253, 706-711 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.382 Acetobacterium dehalogenans O87604
-
-
2.1.1.385 Acetobacterium dehalogenans O87603
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.382 2-hydroxyanisole + [Co(I) methoxylated corrinoid protein OdmA] 67% of the activity with vanillate, O-demethylase complex Acetobacterium dehalogenans [methyl-Co(III) methoxylated corrinoid protein OdmA] + 1,2-dihydroxybenzol
-
 ?
2.1.1.382 isovanillate + [Co(I) methoxylated corrinoid protein OdmA] 26% of the activity with vanillate, O-demethylase complex Acetobacterium dehalogenans [methyl-Co(III) methoxylated corrinoid protein OdmA] + 3,4-dihydroxybenzoate
-
 ?
2.1.1.382 syringate + [Co(I) methoxylated corrinoid protein OdmA] 54% of the activity with vanillate, O-demethylase complex Acetobacterium dehalogenans [methyl-Co(III) methoxylated corrinoid protein OdmA] + ?
-
 ?
2.1.1.382 vanillate + [Co(I) methoxylated corrinoid protein OdmA]
-
 Acetobacterium dehalogenans [methyl-Co(III) methoxylated corrinoid protein OdmA] + 3,4-dihydroxybenzoate
-
 ?
2.1.1.385 [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein] + tetrahydrofolate
-
 Acetobacterium dehalogenans N5-methyltetrahydrofolate + [Co(I) methoxylated-aromatic-compound-specific corrinoid protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.382 OdmB
-
 Acetobacterium dehalogenans
2.1.1.382 vanillate:corrinoid protein methyltransferase
-
 Acetobacterium dehalogenans
2.1.1.385 OdmA
-
 Acetobacterium dehalogenans
2.1.1.385 vanillate specific O-demethylase corrinoid protein
-
 Acetobacterium dehalogenans

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.385 corrinoid for assay, the corrinoid of component A can be reduced with titanium(III) citrate to cob(I)alamin Acetobacterium dehalogenans

General Information

EC Number General Information Comment Organism
2.1.1.382 physiological function an ether-cleaving O-demethylase isolated from syringate-grown cells consists of four proteins, components A, B, C and D. The enzyme system converts only phenyl methyl ethers with a hydroxyl group in the ortho position to the methoxyl moiety. The presence of a carboxyl group in the aromatic compound is not required. Component B serves as vanillate:corrinoid protein methyltransferase (methyltransferase I) mediating the methyl transfer from vanillate to the reduced corrinoid protein component A Acetobacterium dehalogenans
2.1.1.385 physiological function ether-cleaving O-demethylase isolated from syringate-grown cells consists of four proteins, components A, B, C and D. The enzyme system converts only phenyl methyl ethers with a hydroxyl group in the ortho position to the methoxyl moiety. The presence of a carboxyl group in the aromatic compound is not required. Component B serves as vanillate:corrinoid protein methyltransferase (methyltransferase I) mediating the methyl transfer from vanillate to the reduced corrinoid protein component A Acetobacterium dehalogenans