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Literature summary extracted from

  • Walker, M.S.; Walker, J.B.
    Streptomycin biosynthesis. Separation and substrate specificities of phosphatases acting on guanidinodeoxy-scyllo-inositol phosphate and streptomycin-(streptidino)phosphate (1971), J. Biol. Chem., 246, 7034-7040.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.39 phosphate
-
 Streptomyces sp.
3.1.3.40 cystamine
-
 Streptomyces galbus
3.1.3.40 cystamine
-
 Streptomyces griseocarneus
3.1.3.40 cystamine
-
 Streptomyces griseus
3.1.3.40 formamide disulfide hydrochloride
-
 Streptomyces galbus
3.1.3.40 formamide disulfide hydrochloride
-
 Streptomyces griseocarneus
3.1.3.40 formamide disulfide hydrochloride
-
 Streptomyces griseus
3.1.3.40 p-hydroxymercuribenzoate
-
 Streptomyces galbus
3.1.3.40 p-hydroxymercuribenzoate
-
 Streptomyces griseocarneus
3.1.3.40 p-hydroxymercuribenzoate
-
 Streptomyces griseus
3.1.3.40 PO43-
-
 Streptomyces galbus
3.1.3.40 PO43-
-
 Streptomyces griseocarneus
3.1.3.40 PO43-
-
 Streptomyces griseus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.39 Mg2+ required Streptomyces sp.
3.1.3.40 Mg2+ absolute and relatively specific requirement for Streptomyces griseus
3.1.3.40 Mg2+ absolute and relatively specific requirement for Streptomyces griseocarneus
3.1.3.40 Mg2+ absolute and relatively specific requirement for Streptomyces galbus
3.1.3.40 additional information Mn2+, Zn2+, Ca2+, Cu2+, Fe2+, K+ no substitute for Mg2+ Streptomyces griseus
3.1.3.40 additional information Mn2+, Zn2+, Ca2+, Cu2+, Fe2+, K+ no substitute for Mg2+ Streptomyces griseocarneus
3.1.3.40 additional information Mn2+, Zn2+, Ca2+, Cu2+, Fe2+, K+ no substitute for Mg2+ Streptomyces galbus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O Streptomyces griseus streptomycin biosynthesis ?
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O Streptomyces griseocarneus streptomycin biosynthesis ?
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O Streptomyces galbus streptomycin biosynthesis ?
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O Streptomyces griseus streptidine biosynthesis ?
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O Streptomyces griseocarneus streptidine biosynthesis ?
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O Streptomyces galbus streptidine biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.39 Streptomyces sp.
-
-
-
3.1.3.40 Streptomyces galbus
-
 ATCC 14077
-
3.1.3.40 Streptomyces griseocarneus
-
 ATCC 12628
-
3.1.3.40 Streptomyces griseus
-
 ATCC 12475
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.39 mycelium enzyme activity appears following a phase of rapid mycelial growth on complex media Streptomyces sp.
-
3.1.3.40 mycelium
-
 Streptomyces griseus
-
3.1.3.40 mycelium
-
 Streptomyces griseocarneus
-
3.1.3.40 mycelium
-
 Streptomyces galbus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.39 (N'-amidino)streptidine phosphate + H2O
-
 Streptomyces sp. (N'-amidino)streptidine + phosphate
-
 ?
3.1.3.39 dihydrostreptomycin 3'',6-bisphosphate + H2O
-
 Streptomyces sp. dihydrostreptomycin 3''-phosphate + phosphate
-
 ?
3.1.3.39 dihydrostreptomycin 6-phosphate + H2O
-
 Streptomyces sp. dihydrostreptomycin + phosphate
-
 ?
3.1.3.39 N-amidinostreptamine phosphate + H2O
-
 Streptomyces sp. N-amidinostreptamine + phosphate
-
 ?
3.1.3.39 N1-amidinostreptamine 6-phosphate + H2O
-
 Streptomyces sp. N1-amidinostreptamine + phosphate
-
 ?
3.1.3.39 O-phosphoryl-Tris + H2O slow hydrolysis Streptomyces sp. ?
-
 ?
3.1.3.39 streptomycin 6-phosphate + H2O
-
 Streptomyces sp. streptomycin + phosphate
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O
-
 Streptomyces griseus 1-guanidino-1-deoxy-scyllo-inositol + phosphate
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O
-
 Streptomyces griseocarneus 1-guanidino-1-deoxy-scyllo-inositol + phosphate
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O
-
 Streptomyces galbus 1-guanidino-1-deoxy-scyllo-inositol + phosphate
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O streptomycin biosynthesis Streptomyces griseus ?
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O streptomycin biosynthesis Streptomyces griseocarneus ?
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O streptomycin biosynthesis Streptomyces galbus ?
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O streptidine biosynthesis Streptomyces griseus ?
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O streptidine biosynthesis Streptomyces griseocarneus ?
-
 ?
3.1.3.40 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O streptidine biosynthesis Streptomyces galbus ?
-
 ?
3.1.3.40 2-guanidino-2-deoxy-neo-inositol 5-phosphate + H2O
-
 Streptomyces griseus ?
-
 ?
3.1.3.40 2-guanidino-2-deoxy-neo-inositol 5-phosphate + H2O
-
 Streptomyces griseocarneus ?
-
 ?
3.1.3.40 2-guanidino-2-deoxy-neo-inositol 5-phosphate + H2O
-
 Streptomyces galbus ?
-
 ?
3.1.3.40 N-amidinostreptamine phosphate + H2O
-
 Streptomyces griseus N-amidinostreptamine + phosphate
-
 ?
3.1.3.40 N-amidinostreptamine phosphate + H2O
-
 Streptomyces griseocarneus N-amidinostreptamine + phosphate
-
 ?
3.1.3.40 N-amidinostreptamine phosphate + H2O
-
 Streptomyces galbus N-amidinostreptamine + phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.40 7.4
-
-
 Streptomyces griseus
3.1.3.40 7.4
-
-
 Streptomyces griseocarneus
3.1.3.40 7.4
-
-
 Streptomyces galbus