Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Meister, A.
    Asparagine synthesis (1974), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 10, 561-580.
No PubMed abstract available

General Stability

EC Number General Stability Organism
6.3.1.1 glycerol and 2-mercaptoethanol stabilize Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.1.1 iodoacetamide
-
Escherichia coli
6.3.1.1 L-Asp
-
Escherichia coli
6.3.1.1 L-Asp
-
Streptococcus equinus
6.3.1.1 N-ethylmaleimide
-
Escherichia coli
6.3.1.1 p-mercuribenzoate
-
Escherichia coli
6.3.5.4 aminomalonic acid competitive versus L-Asp Mus musculus
6.3.5.4 AMP
-
Mus musculus
6.3.5.4 AMP
-
Rattus norvegicus
6.3.5.4 Asn
-
Mus musculus
6.3.5.4 Asn
-
Rattus norvegicus
6.3.5.4 diphosphate
-
Mus musculus
6.3.5.4 diphosphate
-
Rattus norvegicus
6.3.5.4 L-2-Amino-4-oxo-5-chloropentanoic acid
-
Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.1.1 2
-
ATP
-
Lactiplantibacillus plantarum
6.3.1.1 4
-
NH4+ ATP Streptococcus equinus
6.3.1.1 4.2
-
L-Asp
-
Lactiplantibacillus plantarum
6.3.1.1 26
-
L-Asp
-
Streptococcus equinus
6.3.5.4 0.2
-
ATP
-
Mus musculus
6.3.5.4 0.58
-
L-Asp
-
Rattus norvegicus
6.3.5.4 0.9
-
L-Asp
-
Mus musculus
6.3.5.4 1
-
L-Gln
-
Mus musculus
6.3.5.4 1.1
-
L-Gln
-
Rattus norvegicus
6.3.5.4 9
-
NH4+
-
Mus musculus
6.3.5.4 120
-
NH4+
-
Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.1.1 Mg2+ required Lactiplantibacillus plantarum
6.3.1.1 Mg2+ required Escherichia coli
6.3.1.1 Mg2+ required Streptococcus equinus
6.3.1.1 Mg2+ Km: 45 mM Streptococcus equinus
6.3.1.1 Mn2+ activates Lactiplantibacillus plantarum
6.3.1.1 Mn2+ Km: 3.5 mM Lactiplantibacillus plantarum
6.3.1.1 Mn2+ no activation Escherichia coli
6.3.1.1 Mn2+ no activation Streptococcus equinus
6.3.5.4 Mg2+ divalent metal ion required, Mg2+ more effective than Mn2+ Rattus norvegicus
6.3.5.4 Mg2+ Km: 23.7 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.1.1 82000
-
gel filtration Escherichia coli
6.3.5.4 105000
-
gel filtration Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
6.3.1.1 Escherichia coli
-
K-12
-
6.3.1.1 Escherichia coli
-
overexpression of the fusion protein constructed of asparagine synthetase A structural gene is fused to the 3´end of the human carbonic anhydrase II structural gene
-
6.3.1.1 Lactiplantibacillus plantarum
-
-
-
6.3.1.1 Streptococcus equinus
-
-
-
6.3.5.4 Mammalia
-
-
-
6.3.5.4 Mus musculus
-
-
-
6.3.5.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.5.4 leukemia cell line
-
Mus musculus
-
6.3.5.4 leukemia cell line
-
Rattus norvegicus
-
6.3.5.4 Novikoff hepatoma cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.1.1 ATP + L-Asp + hydroxylamine
-
Escherichia coli AMP + diphosphate + Asn + beta-aspartyl hydroxamate
-
?
6.3.1.1 ATP + L-Asp + hydroxylamine hydroxylamine is more active than NH4+ Lactiplantibacillus plantarum AMP + diphosphate + Asn + beta-aspartyl hydroxamate
-
?
6.3.1.1 ATP + L-Asp + hydroxylamine hydroxylamine is more active than NH4+ Streptococcus equinus AMP + diphosphate + Asn + beta-aspartyl hydroxamate
-
?
6.3.1.1 ATP + L-Asp + NH4+
-
Streptococcus equinus AMP + diphosphate + Asn
-
?
6.3.1.1 ATP + L-Asp + NH4+ no activity with GTP Lactiplantibacillus plantarum AMP + diphosphate + Asn
-
?
6.3.1.1 ATP + L-Asp + NH4+ no activity with ADP, CTP, UTP, or GTP Escherichia coli AMP + diphosphate + Asn
-
?
6.3.1.1 additional information L-Asp-dependent ATP-diphosphate exchange in the absence of added NH4+ Escherichia coli ?
-
?
6.3.1.1 additional information no activity with glutamine Lactiplantibacillus plantarum ?
-
?
6.3.1.1 additional information no activity with glutamine Escherichia coli ?
-
?
6.3.1.1 additional information no activity with glutamine Streptococcus equinus ?
-
?
6.3.5.4 ATP + L-Asp + L-Gln
-
Mammalia AMP + diphosphate + Asn + Glu
-
?
6.3.5.4 ATP + L-Asp + L-Gln
-
Mus musculus AMP + diphosphate + Asn + Glu
-
?
6.3.5.4 ATP + L-Asp + L-Gln
-
Rattus norvegicus AMP + diphosphate + Asn + Glu
-
?
6.3.5.4 ATP + L-Asp + NH2OH
-
Mus musculus AMP + diphosphate + beta-aspartylhydroxamate
-
?
6.3.5.4 ATP + L-Asp + NH2OH
-
Rattus norvegicus AMP + diphosphate + beta-aspartylhydroxamate
-
?
6.3.5.4 ATP + L-Asp + NH3
-
Mus musculus AMP + diphosphate + Asn
-
?
6.3.5.4 ATP + L-Asp + NH3
-
Rattus norvegicus AMP + diphosphate + Asn
-
?
6.3.5.4 ATP + L-Asp + NH3 NH4+ Mammalia AMP + diphosphate + Asn
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.1.1 38 42
-
Lactiplantibacillus plantarum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.1.1 6 6.5
-
Lactiplantibacillus plantarum
6.3.1.1 8 8.4
-
Escherichia coli
6.3.5.4 6.6 8
-
Rattus norvegicus
6.3.5.4 7.6 8.2
-
Mus musculus