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Literature summary extracted from

  • Browne, P.; O'Cuinn, G.
    An evaluation of the role of a pyroglutamyl peptidase, a post-proline cleaving enzyme and a post-proline dipeptidyl amino peptidase, each purified from the soluble fraction of guinea-pig brain, in the degradation of thyroliberin in vitro (1983), Eur. J. Biochem., 137, 75-87.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.19.3 1,10-phenanthroline
-
 Cavia porcellus
3.4.19.3 2-Iodoacetamide
-
 Cavia porcellus
3.4.19.3 8-hydroxyquinoline
-
 Cavia porcellus
3.4.19.3 iodoacetamide
-
 Cavia porcellus
3.4.19.3 NEM
-
 Cavia porcellus
3.4.19.3 PCMB
-
 Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.19.3 0.15
-
 pyroglutamate-4-methylcoumarin 7-amide
-
 Cavia porcellus
3.4.19.3 0.727
-
 Thyroliberin
-
 Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.3 Cavia porcellus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.19.3
-
 Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.19.3 brain
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.19.3 acid-thyroliberin + H2O i.e. pyroglutamyl-His-Pro Cavia porcellus pyroglutamate + His-Pro
-
 ?
3.4.19.3 bombesin + H2O i.e. pyroglutamyl-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 Cavia porcellus pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
-
 ?
3.4.19.3 bradykinin-potentiating peptide B + H2O cleavage of the peptide bond adjacent to the pyroglutamic residue Cavia porcellus ?
-
 ?
3.4.19.3 luliberin + H2O i.e. pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 Cavia porcellus pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
-
 ?
3.4.19.3 neurotensin + H2O i.e. pyroglutamyl-Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu Cavia porcellus pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
 ?
3.4.19.3 pyroglutamyl-4-methylcoumarin 7-amide + H2O
-
 Cavia porcellus pyroglutamate + 7-amino-4-methylcoumarin
-
 ?
3.4.19.3 pyroglutamyl-Ala + H2O
-
 Cavia porcellus pyroglutamate + Ala
-
 ?
3.4.19.3 pyroglutamyl-His-Gly + H2O i.e. anorexogenic peptide Cavia porcellus pyroglutamate + His-Gly
-
 ?
3.4.19.3 thyroliberin + H2O i.e. pyroglutamyl-His-Pro-NH2, i.e. thyrotrophin releasing hormone Cavia porcellus pyroglutamate + His-Pro-NH2
-
 ?