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Version 2014-12-22
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Details for malate dehydrogenase (decarboxylating) (NAD+) activity
1.1.1.38, 1.1.1.39
Gene ontology ID
GO:0004471
Definition
Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+
Comment
For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
Synonyms
1. 'malic' enzyme
2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
3. (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)
4. malate dehydrogenase (decarboxylating) activity
5. malate dehydrogenase (oxaloacetate-decarboxylating) activity
6. NAD-linked malic enzyme
7. NAD-malic enzyme activity
8. NAD-specific malic enzyme
References
1. EC 1.1.1.38
2. EC 1.1.1.39
3. KEGG REACTION: R00214
4. MetaCyc 1.1.1.39-RXN
5. MetaCyc MALIC-NAD-RXN
6. Reactome: R-HSA-9012268 "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR"
7. RHEA: 12653
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