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Gene ontology
Version 2014-12-22
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Details for guanyl-nucleotide exchange factor activity
Gene ontology ID
GO:0005085
Definition
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase
Comment
Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product.
References
1. GOC: kd
2. GOC: mah
3. Reactome: REACT 100054
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Legend
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is a part of the parent element
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derives from the parent element
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