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Version 2014-12-22
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Details for prostaglandin H2 endoperoxidase reductase activity
Gene ontology ID
GO:0036130
Definition
Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate)
Synonyms
1. PGH2 9,11-endoperoxidase
2. PGH2 9-,11-endoperoxide reductase
References
1. GOC: mw
2. KEGG REACTION: R02264
3. PMID 10622721
4. PMID 14979715
5. PMID 16475787
6. Reactome: R-HSA-2161549 "PGH2 is reduced to PGF2a by AKR1C3"
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