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Gene ontology
Version 2014-12-22
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Details for methylenetetrahydrofolate dehydrogenase (NAD+) activity
1.5.1.15
Gene ontology ID
GO:0004487
Definition
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH
Synonyms
1. 5,10-methylenetetrahydrofolate dehydrogenase activity
2. 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
References
1. EC 1.5.1.15
2. RHEA: 22892
3. KEGG REACTION: R01218
4. MetaCyc 1.5.1.15-RXN
5. Reactome: R-HSA-6801462 "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
metabolic process is a
oxidation-reduction process is a
oxidoreductase activity part of
oxidoreductase activity, acting on the CH-NH group of donors is a
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor is a
methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity is a
methylenetetrahydrofolate dehydrogenase (NAD+) activity is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
adaptive thermogenesis is a
ATP metabolic process is a
biosynthetic process is a
catabolic process is a
collagen metabolic process is a
demethylation is a
glycosylation is a
hydrogen metabolic process is a
methylation is a
multi-organism metabolic process is a
NAD metabolic process is a
NADH metabolic process is a
NADP metabolic process is a
nitrogen compound metabolic process is a
organic substance metabolic process is a
oxidation-reduction process is a
iodide oxidation is a
oxidative deethylation is a
oxidoreductase activity part of
1,1,1-trichloroethane reductive dehalogenase activity is a
1,1,2-trichloroethene reductive dehalogenase activity is a
1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity is a
1,1-dichloroethane reductive dehalogenase activity is a
1,2-dichloroethene reductive dehalogenase activity is a
2,4-dichloroaniline reductive dehalogenase activity is a
2,4-dichlorophenoxyacetate dehalogenase activity is a
2,5-dichlorohydroquinone reductive dehalogenase activity is a
2-chloro-N-isopropylacetanilide reductive dehalogenase activity is a
2-octaprenylphenol hydroxylase activity is a
2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity is a
3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity is a
3,3',5-tribromobisphenol A reductive dehalogenase activity is a
3,3'-dibromobisphenol A reductive dehalogenase activity is a
3,8-divinyl protochlorophyllide a 8-vinyl reductase activity is a
3-monobromobisphenol A reductive dehalogenase activity is a
alpha-ketoacid dehydrogenase activity is a
arsenate reductase activity is a
chlorate reductase activity is a
chromate reductase activity is a
crotonyl-CoA reductase activity is a
delta1-piperideine-6-carboxylate dehydrogenase activity is a
dihydronicotinamide riboside quinone reductase activity is a
dihydropterin oxidase activity is a
dimethylarsinate reductase activity is a
dioxygenase activity is a
epoxyqueuosine reductase activity is a
fatty acid alpha-hydroxylase activity is a
geranylgeranyl reductase activity is a
glycyl-radical enzyme activating activity is a
heme-copper terminal oxidase activity is a
hydroxymethylbutenyl pyrophosphate reductase activity is a
malolactic enzyme activity is a
monooxygenase activity is a
NADPH-adrenodoxin reductase activity is a
NADPH:sulfur oxidoreductase activity is a
ortho-trichlorophenol reductive dehalogenase activity is a
oxidoreductase activity, acting on a heme group of donors is a
oxidoreductase activity, acting on a sulfur group of donors is a
oxidoreductase activity, acting on CH or CH2 groups is a
oxidoreductase activity, acting on CH-OH group of donors is a
oxidoreductase activity, acting on diphenols and related substances as donors is a
oxidoreductase activity, acting on halogen in donors is a
oxidoreductase activity, acting on hydrogen as donor is a
oxidoreductase activity, acting on iron-sulfur proteins as donors is a
oxidoreductase activity, acting on NAD(P)H is a
oxidoreductase activity, acting on other nitrogenous compounds as donors is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is a
oxidoreductase activity, acting on peroxide as acceptor is a
oxidoreductase activity, acting on phosphorus or arsenic in donors is a
oxidoreductase activity, acting on reduced flavodoxin as donor is a
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is a
oxidoreductase activity, acting on superoxide radicals as acceptor is a
oxidoreductase activity, acting on the aldehyde or oxo group of donors is a
oxidoreductase activity, acting on the CH-CH group of donors is a
oxidoreductase activity, acting on the CH-NH group of donors is a
5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity is a
6-hydroxypseudooxynicotine dehydrogenase activity is a
coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity is a
cytokinin dehydrogenase activity is a
glyphosate dehydrogenase activity is a
hydroxymonomethylisoproturon dimethylaminedehydrogenase activity is a
iminodiacetate dehydrogenase activity is a
isoproturon dimethylaminedehydrogenase activity is a
L-pipecolate dehydrogenase activity is a
methylenetetrahydromethanopterin dehydrogenase activity is a
methylglutamate dehydrogenase activity is a
monodemethylisoproturon dimethylaminedehydrogenase activity is a
nicotine dehydrogenase activity is a
nitrilotriacetate dehydrogenase activity is a
oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor is a
oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor is a
oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor is a
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor is a
1,2-dehydroreticulinium reductase (NADPH) activity is a
1-pyrroline-5-carboxylate dehydrogenase activity is a
6,7-dihydropteridine reductase activity is a
8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity is a
alanopine dehydrogenase activity is a
berberine reductase activity is a
beta-alanopine dehydrogenase activity is a
carboxynorspermidine dehydrogenase I activity is a
carboxyspermidine dehydrogenase II activity is a
D-lysopine dehydrogenase activity is a
D-nopaline dehydrogenase activity is a
D-octopine dehydrogenase activity is a
dehydropipecolic acid reductase is a
delta1-piperideine-2-carboxylate reductase activity is a
dihydrofolate reductase activity is a
dihydromonapterin reductase activity is a
ephedrine dehydrogenase activity is a
flavin reductase (NADH) activity is a
FMN reductase (NADH) activity is a
FMN reductase (NADPH) activity is a
FMN reductase activity is a
folate reductase activity is a
formyltetrahydrofolate dehydrogenase activity is a
hydroxylamine oxidoreductase activity is a
L-galactose dehydrogenase activity is a
methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity is a
methylenetetrahydrofolate dehydrogenase (NAD+) activity is a
methylenetetrahydrofolate dehydrogenase (NADP+) activity is a
methylenetetrahydrofolate reductase (NAD(P)H) activity is a
N5-(carboxyethyl)ornithine synthase activity is a
opine dehydrogenase activity is a
ornaline synthase activity is a
pteridine reductase activity is a
pyrroline-2-carboxylate reductase activity is a
pyrroline-5-carboxylate reductase activity is a
riboflavin reductase (NADH) activity is a
riboflavin reductase (NADPH) activity is a
saccharopine dehydrogenase activity is a
strombine dehydrogenase activity is a
tauropine dehydrogenase activity is a
thiomorpholine-carboxylate dehydrogenase activity is a
vomilenine reductase activity is a
oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor is a
oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor is a
proline dehydrogenase activity is a
spermidine dehydrogenase activity is a
oxidoreductase activity, acting on the CH-NH2 group of donors is a
oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond is a
oxidoreductase activity, oxidizing metal ions is a
oxygen evolving activity is a
perchlorate reductase activity is a
phthalate dioxygenase reductase activity is a
pyrogallol hydroxytransferase activity is a
reduced coenzyme F420 dehydrogenase activity is a
reduced coenzyme F420 oxidase activity is a
reduced coenzyme F420:quinone oxidoreductase activity is a
selenate reductase activity is a
sphingosine hydroxylase activity is a
steroid dehydrogenase activity is a
sulfur oxygenase reductase activity is a
sulfur reductase activity is a
tetrachloroethene reductive dehalogenase activity is a
tetrahydrothiophene 1-oxide reductase activity is a
thyroxine 5'-deiodinase activity is a
thyroxine 5-deiodinase activity is a
trimethylarsine oxidase activity is a
tyramine-beta hydroxylase activity is a
uracil oxygenase activity is a
vinyl chloride reductive dehalogenase activity is a
violaxanthin de-epoxidase activity is a
thioredoxin reduction is a
pigment metabolic process is a
primary metabolic process is a
respiratory burst is a
secondary metabolic process is a
small molecule metabolic process is a
tartrate metabolic process is a
tyrocidine metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a