1.17.4.4 chloroplast - 9507 745995 1.17.4.4 endoplasmic reticulum - 5783 701401 1.17.4.4 endoplasmic reticulum ER membrane localisation, the enzyme has a typical ER retention signal, KAKRH at the C-terminus of the protein which is indispensable to activity 5783 746471 1.17.4.4 endoplasmic reticulum integral membrane enzyme of the endoplasmic reticulum 5783 744342 1.17.4.4 endoplasmic reticulum integral protein 5783 657400 1.17.4.4 endoplasmic reticulum topology with large loop between transmembrane one and two facing the lumen of the endoplasmic reticulum (ER). A redox sensitive green fluorescent protein is fused to the N- or C-terminus to show that these regions face the cytosol, and introduction of glycosylation sites along with mixed disulfide formation with thioredoxin-like transmembrane protein (TMX) demonstrate ER localization of the major loop 5783 744273 1.17.4.4 endoplasmic reticulum transmembrane protein 5783 656865 1.17.4.4 endoplasmic reticulum membrane - 5789 674854, 716060 1.17.4.4 endoplasmic reticulum membrane integral membrane protein, topology, overview 5789 724800 1.17.4.4 endoplasmic reticulum membrane membrane topology, overview 5789 671387 1.17.4.4 endoplasmic reticulum membrane membrane topology, type III membrane protein, overview 5789 674431 1.17.4.4 endoplasmic reticulum membrane splice variant 2 of vitamin K epoxide reductase complex subunit 1 adopts a single-transmembrane topology placing the C tail in the endoplasmic reticulum lumen 5789 725850 1.17.4.4 endoplasmic reticulum membrane the enzyme contains a VKOR CXXC motif 5789 725921 1.17.4.4 endoplasmic reticulum membrane the enzyme possesses 3 or 4 transmembrane alpha-helices and a large cytoplasmic loop, membrane topology, overview 5789 671387 1.17.4.4 endoplasmic reticulum membrane the N-terminus of VKOR resides in the endoplasmic reticulum lumen, whereas its C-terminus is in the cytoplasm, three- and four-transmembrane domain topology models, overview 5789 725489 1.17.4.4 membrane - 16020 724119, 724460, 725987 1.17.4.4 membrane contains at least one transmembrane domain 16020 656866 1.17.4.4 membrane integral protein 16020 676838 1.17.4.4 membrane intramembrane enzyme 16020 745849 1.17.4.4 membrane topological view of the the membrane spanning enzyme with these four exoplasmic cysteine residues 16020 745224 1.17.4.4 membrane transmembrane protein 16020 701401 1.17.4.4 membrane transmembrane protein with 5 transmembrane helices, membrane topology, overview 16020 716060 1.17.4.4 membrane VKOR is an integral membrane protein 16020 715657 1.17.4.4 membrane VKORC1L1 is a four-transmembrane domain protein with both its termini located in the cytoplasm 16020 745318 1.17.4.4 microsome - - -, 287705, 287707, 287713, 287714, 287715, 287716, 287717, 287719, 287720, 287723, 287724, 657388, 657395, 672166, 674392, 674393, 674854, 689347, 701398, 711627, 724119, 724796, 725028, 746531 1.17.4.4 microsome integral membrane protein - -, 287705, 287706, 287707, 287708, 287710, 287711, 287712, 287719, 287723