3.4.17.23	Cl-	ACE2 activity is regulated by chloride ions. The presence of chloride increases the hydrolysis of angiotensin I by ACE2, but inhibits cleavage of the vasoconstrictor angiotensin II	692319	
3.4.17.23	Cl-	binding ligands are Tyr207 and Arg514, possible model for chloride activation, effect is substrate dependent: activation with angiotensin I and (7-methoxycoumarin-4-yl)acetyl-APK(2,4-dinitrophenyl)-OH, inhibition with angiotensin II	657967	
3.4.17.23	Cl-	enhances activity by about 10fold	659172	
3.4.17.23	Cl-	required, highest activity at 1.5 M NaCl	657531	
3.4.17.23	F-	enhances activity by about 10fold	659172	
3.4.17.23	additional information	metalloprotease	658455	
3.4.17.23	additional information	no effect of Br-	659172	
3.4.17.23	Zinc	zinc carboxypeptidase	695418	
3.4.17.23	Zn2+	-	707036, 709990	
3.4.17.23	Zn2+	contains zinc-binding consensus sequence HEXXH, amino acids 374-378, zinc-binding protease	658963