1.1.1.286	homoisocitrate + NAD+	-	
1.1.1.286	homoisocitrate + NADP+	-	
1.1.1.286	isocitrate + NAD+	-	
1.1.1.286	isocitrate + NADP+	-	
1.1.1.286	additional information	the enzyme catalyzes the fourth reaction of the alpha-aminoadipate pathway for lysine biosynthesis, the conversion of homoisocitrate to alpha-ketoadipate using NAD+ as an oxidizing agent	
1.1.1.286	additional information	in contrast to other homoisicitrate dehydrogenases, the homoisocitrate dehydrogenase from the thermophilic bacterium Thermus thermophilus (TtHICDH) catalyzes the reactions using both homoisocitrate and isocitrate as substrates at similar efficiencies	
1.1.1.286	additional information	Saci_2375 exhibits distinct and similar activities for isocitrate and homoisocitrate, but no detectable activity for 3-isopropylmalate. Saci_2375 is a dual function enzyme serving as isocitrate-homoisocitrate dehydrogenase