1.1.1.42 2-oxoglutarate + CO2 + NADPH + H+ - 1.1.1.42 D-isocitrate + NADP+ enzyme is an integral part of the mitochondrial TCA cycle, and it is involved in providing NADPH for reductive reactions in the cell 1.1.1.42 D-isocitrate + NADP+ the reaction is reversible for isozyme IDP2 1.1.1.42 D-isocitrate + NADP+ - 1.1.1.42 DL-isocitrate + NADP+ - 1.1.1.42 isocitrate + NADP+ - 1.1.1.42 isocitrate + NADP+ IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates 1.1.1.42 isocitrate + NADP+ carbon dioxide-fixing enzyme in the reductive tricarboxylic acid cycle, preference for carboxylation reaction direction 1.1.1.42 isocitrate + NADP+ cytosolic enzyme is critical in fat and cholesterol biosynthesis, enzyme content correlates with adipogenesis in wild-type adipocytes and in transgenic cells 1.1.1.42 isocitrate + NADP+ enzyme has a self-regulatory mechanism of activity mimicking the phosphorylation mechanism of bacterial enzymes 1.1.1.42 isocitrate + NADP+ isozymes are compartment interchangeable for glutamate synthesis, although mitochondrial localization has a positive impact on this function during fermentative growth 1.1.1.42 isocitrate + NADP+ key enzyme of the tricarboxylic acid cycle 1.1.1.42 isocitrate + NADP+ metabolic regulation of the isozymes 1.1.1.42 isocitrate + NADP+ metabolic regulation, involved in the tricarboxylic acid cycle 1.1.1.42 isocitrate + NADP+ the cytosolic isozyme supplies 2-oxoglutarate for the photorespiratory ammonia fixation, pyridine nucleotide contents in mitochondria and cytosol, regulation, overview 1.1.1.42 isocitrate + NADP+ overall reaction 1.1.1.42 isocitrate + NADP+ isocitrate dehydrogenase is an important NADPH-generating enzyme in the endoplasmic reticulum 1.1.1.42 isocitrate + NADP+ the enzyme could have a protective antioxidant role against certain environmental stresses in plants 1.1.1.42 isocitrate + NADP+ strict substrate and coenzyme specificity 1.1.1.42 additional information 86% of total activity in the cell, main factor for synthesis of 2-oxoglutarate. Enzyme and cytoplasmic aspartate aminotransferase are regulated oppositely and the catalytic activity of one enzyme can be stimulated concurrently with a decrease in the activity of the other 1.1.1.42 additional information during oxidative stress, enzyme activity appears to be modulated through enzymatic glutathionylation and deglutathionylation 1.1.1.42 additional information enzyme plays an important regulatory role in cellular defense against oxidative stress and in senescence 1.1.1.42 additional information suppression of enzyme activity by small interfering RNA results in impairment of glucose-stimulated insulin secretion, attenuates glucose-induced increments in pyruvate cycling activity and in NADPH levels, and causes increases in lactate production 1.1.1.42 additional information NADP+-dependent isocitrate dehydrogenase may play an important role in regulating the apoptosis induced by heat shock 1.1.1.42 additional information NADP+-dependent isocitrate dehydrogenase may play an important role in regulating the apoptosis induced by TNF-alpha and anticancer drugs 1.1.1.42 additional information NADP+-dependent isocitrate dehydrogenase plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen 1.1.1.42 additional information IDPm expression in HepG2 cells regulates ethanol-induced toxicity 1.1.1.42 additional information the R132H mutant IDH1 directly converts 2-oxoglutarate to 2-hydroxyglutarate, that rapidly accumulates in the medium of cells expressing R132H mutant IDH1 1.1.1.42 oxalosuccinate -