3.4.17.23	amyloid-beta protein 43 + H2O	ACE2 converts amyloid-beta protein 43 to amyloid-beta protein 42 in mouse brain lysates	
3.4.17.23	angiotensin I + H2O	-	
3.4.17.23	angiotensin I + H2O	ACE2 contributes to the production of angiotensin(1-7) from angiotensin I in proximal straight tubule	
3.4.17.23	angiotensin II + H2O	ACE2 is highly regulated at transcription. ACE2 plays a critical role in regulating the balance between vasoconstrictor and vasodilator effects within the RAS cascade. Angiotensin II may be a stimulus determining cardiac ACE2 gene expression, because either reduction in its levels or prevention of angiotensin II binding to the AT1 receptor increases ACE2 mRNA. ACE2 serves as the cellular entry point for severe acute respiratory syndrome (SARS) virus	
3.4.17.23	angiotensin II + H2O	the uteroplacental location of angiotensin (1-7) and ACE2 in pregnancy suggests an autocrine function of angiotensin(1-7) in the vasoactive regulation that characterizes placentation and establishes pregnancy	
3.4.17.23	angiotensin II + H2O	hepatic production of Ang-(1-7) is catalysed by ACE2	
3.4.17.23	angiotensin II + H2O	the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin	
3.4.17.23	angiotensin II + H2O	the enzyme is involved in the renin angiotensin system	
3.4.17.23	angiotensin II + H2O	-	
3.4.17.23	angiotensin II + H2O	ACE2, a homologue of ACE, EC 3.4.15.1, converts angiotensin II into Ang(1-7). Ang(1-7) shows vasoprotective effects, serum autoantibodies to ACE2 predispose patients with connective tissue diseases to constrictive vasculopathy, pulmonary arterial hypertension, or persistent digital ischemia	
3.4.17.23	angiotensin II + H2O	angiotensin II has many adverse cardiovascular effects when acting through the AT1 receptor	
3.4.17.23	angiotensin II + H2O	high levels of angiotensin II induces pulmonary arterial hypertension	
3.4.17.23	additional information	ACE2 is a crucial SARS-CoV receptor. SARS-CoV infections and the Spike protein of the SARS-CoV reduce ACE2 expression. Injection of SARS-CoV Spike into mice worsens acute lung failure in vivo that can be attenuated by blocking the renin-angiotensin pathway	
3.4.17.23	additional information	angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus	
3.4.17.23	additional information	presence of ACE2 alone is not sufficient for maintaining viral infection. Other virus receptors or coreceptors may be required in different tissues	
3.4.17.23	additional information	the enzyme has a function in blood pressure regulation, blood flow and fluid regulation. Loss of ACE2 impairs heart function	
3.4.17.23	additional information	the enzyme is involved in diesease condition including hypertension, diabetes and cardiac function. ACE2 is the SARS virus receptor	
3.4.17.23	additional information	ACE2 ectodomain shedding and/or sheddase(s) activation regulated by calmodulin is independent from the phorbol ester-induced shedding	
3.4.17.23	additional information	ACE2 is down-regulated and ACE is up-regulated in hypertensive nephropathy. Ang II, once released, can act to up-regulate ACE but down-regulate ACE2 via the AT1 receptor-mediated mechanism. Activation of the ERK1/2 and p38 MAP kinase pathway may represent a key mechanism by which Ang II down-regulates ACE2	
3.4.17.23	additional information	ACE2 is involved in the regulation of heart function, ACE 2 is a functional receptor for the coronavirus that causes the severe acute respiratory syndrome	
3.4.17.23	additional information	ACE2 plays a crucial role in liver fibrogenesis	
3.4.17.23	additional information	ACE2 plays a key role in pulmonary, cardiovascular and hypertensive and diabetic kidney diseases. ACE2 plays a pivotal role in maintaining a balanced status of the RAS synergistically with ACE by exerting counter-regulatory effects	
3.4.17.23	additional information	ACE2 plays a pivotal role in the central regulation of blood pressure and volume homeostasis	
3.4.17.23	additional information	ACE2 plays a protective role in organs directly related to hypertension and associated diseases	
3.4.17.23	additional information	the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited	
3.4.17.23	additional information	ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue	
3.4.17.23	additional information	ACE2 is a terminal carboxypeptidase and the receptor for the SARS and NL63 coronaviruses. Soluble sACE2 acts as receptor binding SARS-CoV glycoprotein S pseudotyped FIV virus and blocks virus infection of target cells	
3.4.17.23	additional information	a combination of ACE2 and ACE convert amyloid-beta protein 43 to amyloid-beta protein 40	
3.4.17.23	QRPRLSHKGPMPF + H2O	i.e. apein(1-13)	
3.4.17.23	YGGFLRRIRPKLK + H2O	i.e. dynorphin A 1-13