1.14.13.178	caffeine + O2 + NAD(P)H + H+	the enzyme forms part of the degradation pathway of methylxanthines. The activity of the enzyme is dependent on electron transfer from NADH via a redox-center-dense Rieske reductase, NdmD	
1.14.13.178	paraxanthine + O2 + NAD(P)H + H+	the enzyme forms part of the degradation pathway of methylxanthines. The activity of the enzyme is dependent on electron transfer from NADH via a redox-center-dense Rieske reductase, NdmD	
1.14.13.178	theophylline + O2 + NAD(P)H + H+	the enzyme forms part of the degradation pathway of methylxanthines. The activity of the enzyme is dependent on electron transfer from NADH via a redox-center-dense Rieske reductase, NdmD	
1.14.13.178	theophylline + O2 + NADPH + H+	i.e. 1,3-dimethylxanthine