1.5.3.17 additional information AtPAO3 catalyzes the sequential conversion/oxidation of spermine to spermidine, and of spermidine to putrescine, thus exhibiting functional homology to the mammalian PAOs, but AtPAO3 does not catalyze the conversion of putrescine back to spermine 1.5.3.17 additional information flavoprotein oxidase Fms1 catalyzes the oxidation of spermine and N1-acetylspermine to spermidine and 3-aminopropanal or N-acetyl-3-aminopropanal 1.5.3.17 N,N'-dibenzyl-1,4-diaminobutane + O2 + H2O slow substrate 1.5.3.17 N1-acetylspermidine + O2 + H2O - 1.5.3.17 N1-acetylspermine + O2 + H2O - 1.5.3.17 spermidine + O2 + H2O - 1.5.3.17 spermine + O2 + H2O - 1.5.3.17 spermine + O2 + H2O slow substrate 1.5.3.17 thermospermine + O2 + H2O - 1.5.3.17 thermospermine + O2 + H2O norspermidine is generated via thermospermine catabolism in Selaginella lepidophylla