1.5.99.4 (S)-nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor - - 1.5.99.4 (S)-nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor A metalloprotein (FMN). Acts on both (R)- and (S)-isomers -