1.14.14.78 malfunction disruption of the CYP4F14 gene causes severe perturbations in vitamin E metabolism 729992 1.14.14.78 metabolism CYP4F14 is the major but not the only vitamin E-omega-hydroxylase in mice 729992 1.14.14.78 physiological function CYP4F2 is the principle leukotriene B4 omega-hydroxylating enzyme expressed in human liver and plays an important role in regulating circulating as well as hepatic levels of this powerful proinflammatory eicosanoid 729093