2.3.1.165	evolution	6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases	719864	
2.3.1.165	metabolism	in toxigenic Penicillium expansum strains msas is involved in the biosynthesis of the mycotoxin patulin which is toxic for animals and plants	703577	
2.3.1.165	metabolism	production of 6-methylsalicylic acid as the first step in biosythesis of isoasperlactone and asperlactone	703824	
2.3.1.165	physiological function	6-methylsalicylic acid synthase from Aspergillus terreus is not involved in dehydration of the beta-hydroxytriketide intermediate tethered on the acyl carrier protein but catalyzes thioester hydrolysis to release the product from the acyl carrier protein, via its thioester hydrolase domain, a product-releasing domain that is located in the middle of a multidomain iterative type I polyketide synthase, ATX by itself can synthesize tetraketide and release 6-methylsalicylate as the free acid without involvement of serine protease-type thioesterase, product-releasing mechanism, overview	719864	
2.3.1.165	physiological function	enzyme is involved in synthesis of yanuthones D and E	-, 735929	
2.3.1.165	physiological function	in Aspergillus aculeatus, 6-methylsalicylic acid is incorporated into aculinic acid, which further incorporates into three compounds named aculins A and B, and epi-aculin A	735950