1.4.1.8 L-2-aminobutyrate + H2O + NAD+ VDH2: preferred substrate, 158% of the activity with L-valine Streptomyces fradiae 2-oxobutyrate + NADH + NH3 VDH2: reductive amination, 100% of the activity with 2-oxoisovalerate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ VDH2: preferred substrate, 158% of the activity with L-valine Streptomyces fradiae 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ 68.9% of the activity with L-valine Streptomyces fradiae 2-oxobutyrate + NADH + NH3 reductive amination: 78% of the activity with 2-oxoisovalerate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ 68.9% of the activity with L-valine Streptomyces fradiae 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ 9% of the activity with L-leucine Priestia megaterium 2-oxobutyrate + NADH + NH3 reductive amination: 28.1% of the activity with 2-oxoisovalerate ? 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ 9% of the activity with L-leucine Priestia megaterium 2-oxobutyrate + NADH + NH3 reductive amination: 28.1% of the activity with 2-oxoisovalerate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ 9% of the activity with L-leucine Priestia megaterium 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate ? 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ 9% of the activity with L-leucine Priestia megaterium 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ 130% of the activity with L-valine Streptomyces coelicolor 2-oxobutyrate + NADH + NH3 - ? 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ preferred substrate, 92.34% of the activity with L-valine Streptomyces albus 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ preferred substrate, 92.34% of the activity with L-valine Streptomyces albus 2-oxobutyrate + NADH + NH3 reductive amination: 91.8% of the activity with 2-oxoisovalerate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ VDH2: 125% of the activity with L-valine Kitasatospora aureofaciens 2-oxobutyrate + NADH + NH3 VDH2: reductive amination, 116% of the activity with 2-oxoisovalerate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ VDH2: 125% of the activity with L-valine Kitasatospora aureofaciens 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Streptomyces coelicolor 2-oxobutyrate + NADH + NH3 - ? 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Priestia megaterium 2-oxobutyrate + NADH + NH3 reductive amination: 28.1% of the activity with 2-oxoisovalerate ? 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Priestia megaterium 2-oxobutyrate + NADH + NH3 reductive amination: 28.1% of the activity with 2-oxoisovalerate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Streptomyces fradiae 2-oxobutyrate + NADH + NH3 reductive amination: 78% of the activity with 2-oxoisovalerate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Streptomyces fradiae 2-oxobutyrate + NADH + NH3 VDH2: reductive amination, 100% of the activity with 2-oxoisovalerate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Kitasatospora aureofaciens 2-oxobutyrate + NADH + NH3 VDH2: reductive amination, 116% of the activity with 2-oxoisovalerate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Priestia megaterium 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate ? 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Priestia megaterium 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Streptomyces albus 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Streptomyces fradiae 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Streptomyces virginiae 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Kitasatospora aureofaciens 2-oxobutyrate + NADH + NH3 2-oxobutyrate is identical with alpha-ketobutyrate r 258948 1.4.1.8 L-2-aminobutyrate + H2O + NAD+ L-2-aminobutyrate is identical with L-alpha-aminobutyrate Streptomyces albus 2-oxobutyrate + NADH + NH3 reductive amination: 91.8% of the activity with 2-oxoisovalerate r 258948 1.4.1.8 L-alanine + H2O + NAD+ - Streptomyces coelicolor pyruvate + NH3 + NADH - r 258952 1.4.1.8 L-alanine + H2O + NAD+ - Streptomyces fradiae pyruvate + NH3 + NADH - r 258952 1.4.1.8 L-alanine + H2O + NAD+ - Streptomyces virginiae pyruvate + NH3 + NADH - ? 258952 1.4.1.8 L-alanine + H2O + NAD+ - Kitasatospora aureofaciens pyruvate + NH3 + NADH - r 258952 1.4.1.8 L-alanine + H2O + NAD+ - Streptomyces virginiae pyruvate + NH3 + NADH pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate ? 258952 1.4.1.8 L-alanine + H2O + NAD+ 5% of the activity with L-valine Streptomyces coelicolor pyruvate + NH3 + NADH - r 258952 1.4.1.8 L-alanine + H2O + NAD+ 14.7% of the activity with L-valine Streptomyces fradiae pyruvate + NH3 + NADH pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate r 258952 1.4.1.8 L-alanine + H2O + NAD+ 14.7% of the activity with L-valine Streptomyces fradiae pyruvate + NH3 + NADH reductive amination: 31.6% of the activity with 2-oxoisovalerate r 258952 1.4.1.8 L-alanine + H2O + NAD+ VDH2: 4.5% of the activity with L-valine Kitasatospora aureofaciens pyruvate + NH3 + NADH pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate r 258952 1.4.1.8 L-alanine + H2O + NAD+ VDH2: 4.5% of the activity with L-valine Kitasatospora aureofaciens pyruvate + NH3 + NADH VDH2: reductive amination, 20.8% of the activity with 2-oxoisovalerate r 258952 1.4.1.8 L-alanine + H2O + NAD+ VDH2: 8.3% of the activity with L-valine Streptomyces fradiae pyruvate + NH3 + NADH pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate r 258952 1.4.1.8 L-alanine + H2O + NAD+ VDH2: 8.3% of the activity with L-valine Streptomyces fradiae pyruvate + NH3 + NADH VDH2: reductive amination, 23.3% of the activity with 2-oxoisovalerate r 258952 1.4.1.8 L-alanine + H2O + NAD+ 3% of the activity with L-valine Priestia megaterium pyruvate + NH3 + NADH reductive amination: 2% of the activity with 2-oxoisovalerate r 258952 1.4.1.8 L-alanine + H2O + NAD+ 3% of the activity with L-valine Priestia megaterium pyruvate + NH3 + NADH pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate r 258952 1.4.1.8 L-alanine + H2O + NAD+ 13.63% of the activity with L-valine Streptomyces albus pyruvate + NH3 + NADH - r 258952 1.4.1.8 L-cysteine + H2O + NAD+ - Streptomyces coelicolor 3-mercapto-2-oxopropanoate + NH3 + NADH - ? 258953 1.4.1.8 L-cysteine + H2O + NAD+ 3% of the activity with L-valine Streptomyces coelicolor 3-mercapto-2-oxopropanoate + NH3 + NADH - ? 258953 1.4.1.8 L-cysteine + H2O + NAD+ 1.87% of the activity with L-valine Streptomyces albus 3-mercapto-2-oxopropanoate + NH3 + NADH - r 258953 1.4.1.8 L-cysteine + H2O + NAD+ 3.75% of the activity with L-valine, A124G mutant: 0.063% Streptomyces albus 3-mercapto-2-oxopropanoate + NH3 + NADH - r 258953 1.4.1.8 L-isoleucine + H2O + NAD+ - Streptomyces coelicolor 3-methyl-2-oxopentanoate + NADH + NH3 - r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ - Streptomyces virginiae 3-methyl-2-oxopentanoate + NADH + NH3 - r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ - Pisum sativum 3-methyl-2-oxopentanoate + NADH + NH3 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate ? 258950 1.4.1.8 L-isoleucine + H2O + NAD+ - Streptomyces fradiae 3-methyl-2-oxopentanoate + NADH + NH3 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ - Kitasatospora aureofaciens 3-methyl-2-oxopentanoate + NADH + NH3 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ - Pisum sativum 3-methyl-2-oxopentanoate + NADH + NH3 reductive amination: 59% of the activity of 2-oxoisovalerate, but no oxidative deamination of L-isoleucine ? 258950 1.4.1.8 L-isoleucine + H2O + NAD+ VDH2: 22% of the activity with L-valine Streptomyces fradiae 3-methyl-2-oxopentanoate + NADH + NH3 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ VDH2: 22% of the activity with L-valine Streptomyces fradiae 3-methyl-2-oxopentanoate + NADH + NH3 VDH2: reductive amination, 16.6% of the activity with 2-oxoisovalerate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ 27.5% of the activity with L-valine, A124G mutant: 9.98% Streptomyces albus 3-methyl-2-oxopentanoate + NADH + NH3 - r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ 29.4% of the activity with L-valine Streptomyces fradiae 3-methyl-2-oxopentanoate + NADH + NH3 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ 29.4% of the activity with L-valine Streptomyces fradiae 3-methyl-2-oxopentanoate + NADH + NH3 reductive amination: 23.2% of the activity with 2-oxoisovalerate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ VDH2: 34% of the activity with L-valine Kitasatospora aureofaciens 3-methyl-2-oxopentanoate + NADH + NH3 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ VDH2: 34% of the activity with L-valine Kitasatospora aureofaciens 3-methyl-2-oxopentanoate + NADH + NH3 VDH2: reductive amination, 24.5% of the activity with 2-oxoisovalerate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ 61.3% of the activity with L-leucine Priestia megaterium 3-methyl-2-oxopentanoate + NADH + NH3 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ 61.3% of the activity with L-leucine Priestia megaterium 3-methyl-2-oxopentanoate + NADH + NH3 reductive amination: 21.9% of the activity with 2-oxoisovalerate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ 12.46% of the activity with L-valine Streptomyces albus 3-methyl-2-oxopentanoate + NADH + NH3 2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ 12.46% of the activity with L-valine Streptomyces albus 3-methyl-2-oxopentanoate + NADH + NH3 reductive amination: 35.6% of the activity with 2-oxoisovalerate r 258950 1.4.1.8 L-isoleucine + H2O + NAD+ 28% of the activity with L-valine Streptomyces coelicolor 3-methyl-2-oxopentanoate + NADH + NH3 - ? 258950 1.4.1.8 L-isoleucine + H2O + NAD+ 27.5% of the activity with L-valine Streptomyces albus 3-methyl-2-oxopentanoate + NADH + NH3 - ? 258950 1.4.1.8 L-leucine + H2O + NAD+ - Streptomyces coelicolor 2-oxoisocaproate + NADH + NH3 - ? 258951 1.4.1.8 L-leucine + H2O + NAD+ - Streptomyces fradiae 2-oxoisocaproate + NADH + NH3 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate r 258951 1.4.1.8 L-leucine + H2O + NAD+ - Streptomyces virginiae 2-oxoisocaproate + NADH + NH3 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate r 258951 1.4.1.8 L-leucine + H2O + NAD+ - Kitasatospora aureofaciens 2-oxoisocaproate + NADH + NH3 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate r 258951 1.4.1.8 L-leucine + H2O + NAD+ preferred substrate Priestia megaterium 2-oxoisocaproate + NADH + NH3 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate r 258951 1.4.1.8 L-leucine + H2O + NAD+ preferred substrate Priestia megaterium 2-oxoisocaproate + NADH + NH3 reductive amination: 21.1% of the activity with 2-oxoisovalerate r 258951 1.4.1.8 L-leucine + H2O + NAD+ 7.46% of the activity with L-valine Streptomyces albus 2-oxoisocaproate + NADH + NH3 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate r 258951 1.4.1.8 L-leucine + H2O + NAD+ 7.46% of the activity with L-valine Streptomyces albus 2-oxoisocaproate + NADH + NH3 reductive amination: 26.85% of the activity with 2-oxoisovalerate r 258951 1.4.1.8 L-leucine + H2O + NAD+ 24.5% of the activity with L-valine Streptomyces fradiae 2-oxoisocaproate + NADH + NH3 reductive amination: 20% of the activity with 2-oxoisovalerate r 258951 1.4.1.8 L-leucine + H2O + NAD+ 24.5% of the activity with L-valine Streptomyces fradiae 2-oxoisocaproate + NADH + NH3 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate r 258951 1.4.1.8 L-leucine + H2O + NAD+ VDH2: 52.8% of the activity with L-valine Kitasatospora aureofaciens 2-oxoisocaproate + NADH + NH3 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate r 258951 1.4.1.8 L-leucine + H2O + NAD+ VDH2: 52.8% of the activity with L-valine Kitasatospora aureofaciens 2-oxoisocaproate + NADH + NH3 VDH2: reductive amination, 26.5% of the activity with 2-oxoisovalerate r 258951 1.4.1.8 L-leucine + H2O + NAD+ 8% of the activity with L-valine Streptomyces coelicolor 2-oxoisocaproate + NADH + NH3 - ? 258951 1.4.1.8 L-leucine + H2O + NAD+ VDH2: 24% of the activity with L-valine Streptomyces fradiae 2-oxoisocaproate + NADH + NH3 2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate r 258951 1.4.1.8 L-leucine + H2O + NAD+ VDH2: 24% of the activity with L-valine Streptomyces fradiae 2-oxoisocaproate + NADH + NH3 VDH2: reductive amination, 20% of the activity with 2-oxoisovalerate r 258951 1.4.1.8 L-leucine + H2O + NAD+ 15% of the activity with L-valine, A124G mutant: 5.03% Streptomyces albus 2-oxoisocaproate + NADH + NH3 - r 258951 1.4.1.8 L-leucine + H2O + NAD+ 15% of the activity with L-valine Streptomyces albus 2-oxoisocaproate + NADH + NH3 - ? 258951 1.4.1.8 L-methionine + H2O + NAD+ VDH2: 2% of the activity with L-valine Kitasatospora aureofaciens 4-(methylthio)-2-oxobutanoic acid + NH3 + NADH - r 258955 1.4.1.8 L-norleucine + H2O + NAD+ - Streptomyces virginiae 2-oxocaproate + NADH + NH3 2-oxocaproate is identical with 2-oxohexanoate and alpha-keto-n-hexanoate r 258949 1.4.1.8 L-norleucine + H2O + NAD+ 4.7% of the activity with L-valine Priestia megaterium 2-oxocaproate + NADH + NH3 reductive amination: 9.7% of the activity with 2-oxoisovalerate r 258949 1.4.1.8 L-norleucine + H2O + NAD+ 4.7% of the activity with L-valine Priestia megaterium 2-oxocaproate + NADH + NH3 2-oxocaproate is identical with 2-oxohexanoate and alpha-keto-n-hexanoate r 258949 1.4.1.8 L-norleucine + H2O + NAD+ VDH2: 34.5% of the activity with L-valine Streptomyces fradiae 2-oxocaproate + NADH + NH3 - r 258949 1.4.1.8 L-norleucine + H2O + NAD+ 15% of the activity with L-valine, A124G mutant: 15% Streptomyces albus 2-oxocaproate + NADH + NH3 - r 258949 1.4.1.8 L-norleucine + H2O + NAD+ VDH2: 18.5% of the activity with L-valine Kitasatospora aureofaciens 2-oxocaproate + NADH + NH3 - r 258949 1.4.1.8 L-norleucine + H2O + NAD+ 51.5% of the activity with L-valine Streptomyces fradiae 2-oxocaproate + NADH + NH3 2-oxocaproate is identical with 2-oxohexanoate and alpha-keto-n-hexanoate r 258949 1.4.1.8 L-norleucine + H2O + NAD+ 51.5% of the activity with L-valine Streptomyces fradiae 2-oxocaproate + NADH + NH3 reductive amination: 43.8% of the activity with 2-oxoisovalerate r 258949 1.4.1.8 L-norleucine + H2O + NAD+ 15% of the activity with L-valine Streptomyces albus 2-oxocaproate + NADH + NH3 - ? 258949 1.4.1.8 L-norvaline + H2O + NAD+ - Streptomyces virginiae 2-oxovalerate + NH3 + NADH optimal chain length for reductive amination r 258947 1.4.1.8 L-norvaline + H2O + NAD+ - Streptomyces virginiae 2-oxovalerate + NH3 + NADH 2-oxovalerate is identical with 2-oxopentanoate and alpha-ketovalerate r 258947 1.4.1.8 L-norvaline + H2O + NAD+ 98% of the activity with L-valine Streptomyces fradiae 2-oxovalerate + NH3 + NADH reductive amination: 79.5% of the activity with 2-oxoisovalerate r 258947 1.4.1.8 L-norvaline + H2O + NAD+ 98% of the activity with L-valine Streptomyces fradiae 2-oxovalerate + NH3 + NADH 2-oxovalerate is identical with 2-oxopentanoate and alpha-ketovalerate r 258947 1.4.1.8 L-norvaline + H2O + NAD+ VDH2: 100% of the activity with L-valine Kitasatospora aureofaciens 2-oxovalerate + NH3 + NADH - r 258947 1.4.1.8 L-norvaline + H2O + NAD+ VDH2: 96% of the activity with L-valine Streptomyces fradiae 2-oxovalerate + NH3 + NADH - r 258947 1.4.1.8 L-norvaline + H2O + NAD+ 47.2% of the activity with L-leucine Priestia megaterium 2-oxovalerate + NH3 + NADH reductive amination: 37% of the activity with 2-oxoisovalerate r 258947 1.4.1.8 L-norvaline + H2O + NAD+ 47.2% of the activity with L-leucine Priestia megaterium 2-oxovalerate + NH3 + NADH 2-oxovalerate is identical with 2-oxopentanoate and alpha-ketovalerate r 258947 1.4.1.8 L-norvaline + H2O + NAD+ 100.5% of the activity of L-valine, A124G mutant: 28.77% Streptomyces albus 2-oxovalerate + NH3 + NADH - r 258947 1.4.1.8 L-norvaline + H2O + NAD+ as active as with L-valine Streptomyces albus 2-oxovalerate + NH3 + NADH - ? 258947 1.4.1.8 L-phenylalanine + H2O + NAD+ only 0.95% of the activity with L-valine Streptomyces albus 2-oxo-3-phenylpropanoic acid + NH3 + NADH - r 258954 1.4.1.8 L-phenylalanine + H2O + NAD+ 1.25% of the activity with L-valine, A124G mutant: 2.5% Streptomyces albus 2-oxo-3-phenylpropanoic acid + NH3 + NADH - r 258954 1.4.1.8 L-valine + NAD(P)+ + H2O - Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O - Streptomyces virginiae 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O - Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O preferred substrate Streptomyces albus 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O preferred substrate Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O preferred substrate Streptomyces albus 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O preferred substrate Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O preferred substrate Streptomyces albus 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O preferred substrate Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Priestia megaterium 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces coelicolor 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces albus 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces virginiae 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Priestia megaterium 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces coelicolor 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces albus 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces virginiae 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Priestia megaterium 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces albus 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces virginiae 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O A124G mutant: 3.75% of the activity with L-valine in wild type Streptomyces albus 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O A124G mutant: 3.75% of the activity with L-valine in wild type Streptomyces albus 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O 88.9% of the activity with L-leucine Priestia megaterium 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O 88.9% of the activity with L-leucine Priestia megaterium 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O 88.9% of the activity with L-leucine Priestia megaterium 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Phaseolus vulgaris 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Triticum aestivum 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Zea mays 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Glycine max 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Plantago sp. 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Phaseolus vulgaris 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Triticum aestivum 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Zea mays 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Glycine max 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Plantago sp. 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Phaseolus vulgaris 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Triticum aestivum 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Zea mays 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Glycine max 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Plantago sp. 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O soluble enzyme in roots: ratio of rate of reductive amination of valine ketoanalogue to the rate of oxidative deamination of L-valine is 1:1 Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O soluble enzyme in roots: ratio of rate of reductive amination of valine ketoanalogue to the rate of oxidative deamination of L-valine is 1:1 Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O soluble enzyme in roots: ratio of rate of reductive amination of valine ketoanalogue to the rate of oxidative deamination of L-valine is 1:1 Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O rate of reductive amination of ketoanalogue of valine 5 times greater than rate of oxidative deamination of L-valine Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O rate of reductive amination of ketoanalogue of valine 5 times greater than rate of oxidative deamination of L-valine Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O reductive amination rate is twice the oxidative deamination rate Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O reductive amination rate is twice the oxidative deamination rate Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O reductive amination rate is twice the oxidative deamination rate Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Phaseolus vulgaris 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Triticum aestivum 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Zea mays 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Glycine max 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Plantago sp. 2-oxoisovalerate + NH3 + NAD(P)H NADPH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Phaseolus vulgaris 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Triticum aestivum 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Zea mays 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Glycine max 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 2.5:1 Plantago sp. 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O L-valine oxidized efficiently Streptomyces coelicolor 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O L-valine oxidized efficiently Streptomyces coelicolor 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 5:1 Phaseolus vulgaris 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 5:1 Triticum aestivum 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 5:1 Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 5:1 Zea mays 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 5:1 Glycine max 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O in the enzyme associated with subcellular structures in shoots it is 5:1 Plantago sp. 2-oxoisovalerate + NH3 + NAD(P)H - r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O VDH2 rather than VDH1 plays a role in metabolism of branched chain amino acids and thus in tylosin biosynthesis, expression of VDH1 is unstable Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Streptomyces coelicolor 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Streptomyces albus 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O VDH is required for utilization of branched chain amino acids, the catabolism appears to be an alternative source of n-butyrate, 2-methylmalonate, and propionate needed for biosynthesis of macrolide and polyether antibiotics Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O VDH is required for utilization of branched chain amino acids, the catabolism appears to be an alternative source of n-butyrate, 2-methylmalonate, and propionate needed for biosynthesis of macrolide and polyether antibiotics Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O regulatory enzyme involved in biosynthesis of n-butyrate, a building unit of the oligoketide antibiotic tylosin, NAD+ as natural cofactor for oxidative deamination Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O first catabolic step of L-valine and some other branched chain L-amino acids, important role in providing precursors for biosynthesis of polyether antibiotic, salinomycin, that is produced at a high level Streptomyces albus 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O first step in valine catabolism Streptomyces coelicolor 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O first step in valine catabolism Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O first step in valine catabolism Streptomyces virginiae 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O first step in valine catabolism Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O two forms of enzyme activity: enzyme associated with subcellular structures in shoots or leaves probably plays a biosynthetic role for valine production and the soluble enzyme in roots plays a degradative role in valine catabolism Pisum sativum 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces coelicolor A3(2) 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces coelicolor A3(2) 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O L-valine oxidized efficiently Streptomyces coelicolor A3(2) 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O L-valine oxidized efficiently Streptomyces coelicolor A3(2) 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O - Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O first step in valine catabolism Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O VDH is required for utilization of branched chain amino acids, the catabolism appears to be an alternative source of n-butyrate, 2-methylmalonate, and propionate needed for biosynthesis of macrolide and polyether antibiotics Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NAD+ Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O NADP+ Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O - Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O first step in valine catabolism Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H - ? 258946 1.4.1.8 L-valine + NAD(P)+ + H2O preferred substrate Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H NADH r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O preferred substrate Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate r 258946 1.4.1.8 L-valine + NAD(P)+ + H2O preferred substrate Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H reductive amination: preferred substrate r 258946 1.4.1.8 L-valine + NAD+ + H2O - Streptomyces albus 2-oxoisovalerate + NH3 + NADH - ? 389077 1.4.1.8 additional information - Phaseolus vulgaris additional information - ? 1440 1.4.1.8 additional information - Triticum aestivum additional information - ? 1440 1.4.1.8 additional information - Zea mays additional information - ? 1440 1.4.1.8 additional information - Glycine max additional information - ? 1440 1.4.1.8 additional information - Streptomyces fradiae additional information - ? 1440 1.4.1.8 additional information - Streptomyces virginiae additional information - ? 1440 1.4.1.8 additional information - Plantago sp. additional information - ? 1440 1.4.1.8 additional information NH3 is the sole substrate as amino donor Streptomyces fradiae additional information - ? 1440 1.4.1.8 additional information NH3 is the sole substrate as amino donor Streptomyces virginiae additional information reductive amination: sequential ordered ternary-binary mechanism ? 1440 1.4.1.8 additional information no oxidative deamination of L-isoleucine and L-alanine Pisum sativum additional information no reductive amination of 2-oxobutyrate ? 1440 1.4.1.8 additional information pro-S hydrogen at C-4' of NADH is transferred to substrate, B-stereospecific Streptomyces virginiae additional information reductive amination: sequential ordered ternary-binary mechanism ? 1440 1.4.1.8 additional information Lys-79, Lys-91 are involved in substrate binding and catalysis Streptomyces albus additional information - ? 1440 1.4.1.8 additional information not: D-valine Streptomyces coelicolor additional information - ? 1440 1.4.1.8 additional information not: D-valine Streptomyces albus additional information - ? 1440 1.4.1.8 additional information Ala-124 is involved in substrate binding, but less of nicotinamide coenzyme Streptomyces albus additional information - ? 1440 1.4.1.8 additional information no activity with the D-isomers of the substrates Priestia megaterium additional information - ? 1440 1.4.1.8 additional information not: D-valine Streptomyces coelicolor A3(2) additional information - ? 1440 1.4.1.8 additional information NH3 is the sole substrate as amino donor Streptomyces fradiae 30/3 additional information - ? 1440