1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Heterostelium pallidum acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Aphanomyces astaci acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Aphanomyces invadans acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Saprolegnia parasitica acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Saprolegnia diclina acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Thecamonas trahens acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Dictyostelium purpureum acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Acytostelium subglobosum acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Acytostelium subglobosum LB1 acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Aphanomyces astaci APO3 acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Saprolegnia parasitica CBS223.65 acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Aphanomyces invadans NJM9701 acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Saprolegnia diclina VS20 acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 (S)-3-hydroxybutanoate + 2-oxoglutarate - Thecamonas trahens ATCC 50062 acetoacetate + (R)-2-hydroxyglutarate - ? 438034 1.1.99.24 3-hydroxybutyrate + 2-oxoglutarate - Homo sapiens succinic semialdehyde + D-2-hydroxyglutarate - r 386124 1.1.99.24 3-hydroxybutyrate + 2-oxoglutarate radiolabeled substrate 3-hydroxybutyrate, stereospecific reaction Homo sapiens succinic semialdehyde + D-2-hydroxyglutarate radiolabeled product D-2-hydroxyglutarate r 386124 1.1.99.24 4-hydroxybutanoic acid + 2-oxoglutarate - Homo sapiens succinic semialdehyde + D-2-hydroxyglutarate - ? 403852 1.1.99.24 4-hydroxybutyrate + 2-oxoglutarate - Rattus norvegicus succinic semialdehyde + 2-hydroxyglutarate - r 189009 1.1.99.24 4-hydroxybutyrate + 2-oxoglutarate hydrogen attached to hydroxyl-bearing C of 4-hydroxybutyrate is transferred to ketone-bearing C of 2-oxoglutarate, oxoacid not NAD+ or NADP+ acts as hydrogen acceptor Rattus norvegicus succinic semialdehyde + 2-hydroxyglutarate - r 189009 1.1.99.24 4-hydroxybutyrate + 2-oxoglutarate hydrogen attached to hydroxyl-bearing C of 4-hydroxybutyrate is transferred to ketone-bearing C of 2-oxoglutarate, oxoacid not NAD+ or NADP+ acts as hydrogen acceptor Rattus norvegicus Sprague-Dawley succinic semialdehyde + 2-hydroxyglutarate - r 189009 1.1.99.24 4-hydroxybutyrate + 2-oxoglutarate - Homo sapiens D-2-hydroxyglutarate + succinate semialdehyde - ? 380451 1.1.99.24 4-hydroxybutyrate + 2-oxoglutarate - Rattus norvegicus D-2-hydroxyglutarate + succinate semialdehyde - ? 380451 1.1.99.24 4-hydroxybutyrate + 2-oxoglutarate - Mus musculus succinic semialdehyde + D-2-hydroxyglutarate - ? 386146 1.1.99.24 4-hydroxybutyrate + 2-oxoglutarate - Rattus norvegicus succinic semialdehyde + D-2-hydroxyglutarate - r 386146 1.1.99.24 4-hydroxybutyrate + 2-oxoglutarate recombinant enzyme in HEK-293 cells Mus musculus succinic semialdehyde + D-2-hydroxyglutarate - ? 386146 1.1.99.24 4-hydroxybutyrate + 2-oxoglutarate stereospecific reaction, no activity with L-2-hydroxyglutarate Rattus norvegicus succinic semialdehyde + D-2-hydroxyglutarate - r 386146 1.1.99.24 D-2-hydroxybutyrate + 2-oxoglutarate - Rattus norvegicus ? - r 451172 1.1.99.24 D-2-hydroxyglutarate + succinic semialdehyde - Rattus norvegicus 2-oxoglutarate + 4-hydroxybutyrate - ? 189010 1.1.99.24 D-2-hydroxyglutarate + succinic semialdehyde - Rattus norvegicus Sprague-Dawley 2-oxoglutarate + 4-hydroxybutyrate - ? 189010 1.1.99.24 L-3-hydroxybutyrate + 2-oxoglutarate - Rattus norvegicus acetoacetate + 2-oxoglutarate - ? 189011 1.1.99.24 L-3-hydroxybutyrate + 2-oxoglutarate oxidized at 33% the rate of 4-hydroxybutyrate Rattus norvegicus acetoacetate + 2-oxoglutarate - ? 189011 1.1.99.24 L-3-hydroxybutyrate + 2-oxoglutarate oxidized at 33% the rate of 4-hydroxybutyrate Rattus norvegicus Sprague-Dawley acetoacetate + 2-oxoglutarate - ? 189011 1.1.99.24 L-3-hydroxybutyrate + succinic semialdehyde - Rattus norvegicus acetoacetate + 4-hydroxybutyrate - ? 189012 1.1.99.24 L-3-hydroxybutyrate + succinic semialdehyde oxo-acids that can act as hydrogen acceptors are 2-oxoadipate, 24% as effective as 2-oxoglutarate and oxaloacetate, 19% as effective as 2-oxoglutarate, D-3-hydroxybutyrate, DL-2-hydroxybutyrate, D/L-malate, D/L-lactate, acetoacetate, 3-oxobutyrate, 3-oxoadipate do not act as hydrogen acceptors, poor acceptors are pyruvate and 2-oxobutyrate Rattus norvegicus acetoacetate + 4-hydroxybutyrate - ? 189012 1.1.99.24 L-3-hydroxybutyrate + succinic semialdehyde 62.5% of activity with D-2-hydroxyglutarate Rattus norvegicus acetoacetate + 4-hydroxybutyrate - ? 189012 1.1.99.24 L-3-hydroxybutyrate + succinic semialdehyde oxo-acids that can act as hydrogen acceptors are 2-oxoadipate, 24% as effective as 2-oxoglutarate and oxaloacetate, 19% as effective as 2-oxoglutarate, D-3-hydroxybutyrate, DL-2-hydroxybutyrate, D/L-malate, D/L-lactate, acetoacetate, 3-oxobutyrate, 3-oxoadipate do not act as hydrogen acceptors, poor acceptors are pyruvate and 2-oxobutyrate Rattus norvegicus Sprague-Dawley acetoacetate + 4-hydroxybutyrate - ? 189012 1.1.99.24 L-3-hydroxybutyrate + succinic semialdehyde 62.5% of activity with D-2-hydroxyglutarate Rattus norvegicus Sprague-Dawley acetoacetate + 4-hydroxybutyrate - ? 189012 1.1.99.24 additional information D-2-hydroxyglutaric aciduria is not associated to the enzyme activity Homo sapiens ? - ? 89