1.13.11.65	3-hydroxy-beta-apo-10'-carotenal + O2	-	Mycobacterium tuberculosis	3-hydroxy-beta-apo-13-carotenone + 3-hydroxy-beta-apo-15-carotenal	plus a minor product presumably representing 3-hydroxy-beta-apo-11-carotenal	?	419981	
1.13.11.65	3-hydroxy-beta-apo-8'-carotenal + O2	-	Mycobacterium tuberculosis	?	-	?	411283	
1.13.11.65	4-vinylguaiacol + O2	-	Caulobacter segnis	vanillin	-	?	461486	
1.13.11.65	4-vinylguaiacol + O2	-	Caulobacter segnis ATCC 21756	vanillin	-	?	461486	
1.13.11.65	alpha-carotene + O2	-	Galleria mellonella	?	-	?	418450	
1.13.11.65	apo-8'-carotenal + O2	-	Sphingopyxis alaskensis	?	-	?	420296	
1.13.11.65	apo-8'-carotenal + O2	-	Plesiocystis pacifica SIR-1	?	cleavage at the 9'/10'- and 11'/12'-double bond	?	420296	
1.13.11.65	apo-8'-carotenal + O2	-	Sphingopyxis alaskensis	?	cleavage at the 9'/10'- and 11'/12'-double bond	?	420296	
1.13.11.65	astaxanthin + O2	-	Plesiocystis pacifica SIR-1	?	single cleavage site at the 13'/14' double bond	?	404376	
1.13.11.65	beta,beta-carotene + O2	-	Drosophila melanogaster	all-trans-retinal + 11-cis-retinal	-	?	420370	
1.13.11.65	beta,beta-carotene + O2	-	Galleria mellonella	all-trans-retinal + 11-cis-retinal	enzyme catalyzes the production of 11-cis-retinal and all-trans-retinal, i.e. cleavage at the 15,15' double bond. The 11-cis-retinal product maybe thermally converted either into the all-trans or the 13-cis stereoisomer in the aqueous test solution	?	420370	
1.13.11.65	beta-apo-10'-carotenal + O2	-	Mycobacterium tuberculosis	beta-apo-13-carotenone	plus minor amounts of beta-apo-15-carotenal	?	420375	
1.13.11.65	beta-apo-8'-carotenal + O2	-	Mycobacterium tuberculosis	beta-apo-13-carotenone + retinal	-	?	420376	
1.13.11.65	beta-carotene + O2	-	Mycobacterium tuberculosis	retinal + beta-apo-14'-carotenal + beta-apo-13-carotenone	-	?	411747	
1.13.11.65	canthaxanthin + O2	-	Plesiocystis pacifica SIR-1	?	two cleavage sites at the 11'/12' or 13'/14' double bond	?	404589	
1.13.11.65	cryptoxanthin + O2	-	Galleria mellonella	11-cis-3-hydroxyretinal + 11-cis-retinal	11-cis-3-hydroxyretinal and 11-cis-retinal exist in a molar ratio of 8:1, indicating that the enzyme preferentially isomerizes the half site of cryptoxanthin with the hydroxylated beta-ionone ring	?	420504	
1.13.11.65	decaprenoxanthin + O2	-	Plesiocystis pacifica SIR-1	?	-	?	420570	
1.13.11.65	dihydroxylycopene + O2	-	Sphingopyxis alaskensis	?	-	?	420604	
1.13.11.65	dihydroxylycopene + O2	i.e. 1,2,1',2'-tetrahydro-psi,psi-carotene-1,1'-diol	Plesiocystis pacifica SIR-1	?	-	?	420604	
1.13.11.65	dihydroxylycopene + O2	i.e. 1,2,1',2'-tetrahydro-psi,psi-carotene-1,1'-diol	Sphingopyxis alaskensis	?	-	?	420604	
1.13.11.65	hydroxylycopene + O2	-	Sphingopyxis alaskensis	?	-	?	420798	
1.13.11.65	hydroxylycopene + O2	i.e. 1,2-dihydro-psi,psi-carotene-1-ol	Plesiocystis pacifica SIR-1	?	-	?	420798	
1.13.11.65	hydroxylycopene + O2	i.e. 1,2-dihydro-psi,psi-carotene-1-ol	Sphingopyxis alaskensis	?	-	?	420798	
1.13.11.65	lutein + O2	-	Mycobacterium tuberculosis	?	-	?	412389	
1.13.11.65	lutein + O2	-	Galleria mellonella	?	-	?	412389	
1.13.11.65	lycopene + O2	-	Sphingopyxis alaskensis	?	-	?	389114	
1.13.11.65	additional information	enzyme carotenoid cleavage requires the presence of either hydroxy or keto groups	Plesiocystis pacifica SIR-1	?	-	?	89	
1.13.11.65	additional information	enzyme cleaves acyclic and monocyclic substrates	Sphingopyxis alaskensis	?	-	?	89	
1.13.11.65	additional information	enzyme cleaves the central C15-C15' and an excentric double bond at the C13-C14 position, leading to retinal (C20), beta-apo-14'-carotenal (C22) and beta-apo-13-carotenone (C18) from beta-carotene, as well as the corresponding hydroxylated products from zeaxanthin and lutein. Enzyme also cleaves 3,3'-dihydroxy-isorenieratene representing aromatic carotenoids synthesized by other mycobacteria. The preference for each of the cleavage positions is determined by the hydroxylation and the nature of the ionone ring. Incubation of apocarotenoids shorter than beta-apo-10'-carotenal reveals only weak activity, substrates with a shorter chain length are not converted	Mycobacterium tuberculosis	?	-	?	89	
1.13.11.65	additional information	enzyme combines isomerase and isomerooxygenase activity in a single polypeptide	Drosophila melanogaster	?	-	?	89	
1.13.11.65	additional information	enzyme combines isomerase and isomerooxygenase activity in a single polypeptide	Galleria mellonella	?	-	?	89	
1.13.11.65	additional information	no substrates: resveratrol, cholecalciferol, phylloquinone and alpha-tocopherol	Mycobacterium tuberculosis	?	-	?	89	
1.13.11.65	nostoxanthin + O2	-	Plesiocystis pacifica SIR-1	?	two cleavage sites at the 11'/12' or 13'/14' double bond	?	421130	
1.13.11.65	sarcinaxanthin + O2	-	Plesiocystis pacifica SIR-1	?	-	?	421485	
1.13.11.65	sarprenoxanthin + O2	-	Plesiocystis pacifica SIR-1	?	-	?	421489	
1.13.11.65	zeaxanthin + O2	-	Mycobacterium tuberculosis	?	-	?	390099	
1.13.11.65	zeaxanthin + O2	-	Plesiocystis pacifica SIR-1	?	two cleavage sites at the 11'/12' or 13'/14' double bond	?	390099	
1.13.11.65	zeaxanthin + O2	-	Sphingopyxis alaskensis	(3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal	-	?	406916	
1.13.11.65	zeaxanthin + O2	-	Drosophila melanogaster	(3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal	beta-carotene is first converted to zeaxanthin and then cleaved by the enzmye to directly yield 3-hydroxy-retinal	?	406916	
1.13.11.65	zeaxanthin + O2	-	Galleria mellonella	(3R)-all-trans-3-hydroxyretinal + (3R)-11-cis-3-hydroxyretinal	-	?	421714