1.2.1.48 2-hydroxyhexadecanal + NAD+ + H2O - Cricetulus griseus 2-hydroxyhexadecanoic acid + NADH + 2 H+ - ? 460507 1.2.1.48 4,4'-diapolycopendial + NAD+ + H2O - Staphylococcus aureus 4,4'-diapolycopen-4'-al-4-oic acid + NADH + H+ - ? 460648 1.2.1.48 a long-chain aldehyde + NAD+ + H2O - Homo sapiens a long-chain carboxylate + NADH + 2 H+ - ? 440133 1.2.1.48 acetaldehyde + NAD+ + H2O - Homo sapiens acetate + NADH + H+ - ? 189125 1.2.1.48 acetaldehyde + NAD+ + H2O - Geobacillus thermoleovorans acetate + NADH + H+ - ? 189125 1.2.1.48 acetaldehyde + NAD+ + H2O - Geobacillus thermoleovorans B23 acetate + NADH + H+ - ? 189125 1.2.1.48 arachidic aldehyde + NAD+ + H2O - Homo sapiens arachidic acid + NADH - ? 258153 1.2.1.48 behenic aldehyde + NAD+ + H2O - Homo sapiens behenic acid + NADH - ? 258154 1.2.1.48 benzaldehyde + NAD+ + H2O - Homo sapiens benzoate + NADH + H+ - ? 189127 1.2.1.48 benzaldehyde + NAD+ + H2O - Geobacillus thermoleovorans benzoate + NADH + H+ - ? 189127 1.2.1.48 benzaldehyde + NAD+ + H2O 66% activity toward tetradecanal Acinetobacter sp. benzoate + NADH + H+ - ? 189127 1.2.1.48 benzaldehyde + NAD+ + H2O - Geobacillus thermoleovorans B23 benzoate + NADH + H+ - ? 189127 1.2.1.48 benzaldehyde + NAD+ + H2O 66% activity toward tetradecanal Acinetobacter sp. M-1 benzoate + NADH + H+ - ? 189127 1.2.1.48 benzaldehyde + NAD+ + H2O - Staphylococcus aureus benzoate + NADH + 2 H+ - ? 425996 1.2.1.48 betaine aldehyde + NAD+ + H2O - Geobacillus thermoleovorans ? - ? 402514 1.2.1.48 cis,cis-9,12-octadecadienal + NAD+ + H2O - Homo sapiens cis,cis-9,12-octadecadienoic acid + NADH - ? 258141 1.2.1.48 cis,cis-9,12-octadecadienal + NAD+ + H2O major substrate Mus musculus cis,cis-9,12-octadecadienoic acid + NADH - ? 258141 1.2.1.48 cis,cis-9,12-octadecadienal + NAD+ + H2O major substrate Homo sapiens cis,cis-9,12-octadecadienoic acid + NADH - ? 258141 1.2.1.48 cis,cis-9,12-octadecadienal + NAD+ + H2O major substrate Rattus norvegicus cis,cis-9,12-octadecadienoic acid + NADH - ? 258141 1.2.1.48 cis-11-hexadecenal + NAD+ + H2O - Homo sapiens cis-11-hexadecenoic acid + NADH + H+ - ? 400678 1.2.1.48 cis-9-hexadecenal + NAD+ + H2O - Homo sapiens cis-9-hexadecenoic acid + NADH - ? 258139 1.2.1.48 cis-9-hexadecenal + NAD+ + H2O 31% activity toward tetradecanal Acinetobacter sp. cis-9-hexadecenoic acid + NADH - ? 258139 1.2.1.48 cis-9-octadecenal + NAD+ + H2O - Homo sapiens cis-9-octadecenoic acid + NADH - ? 258140 1.2.1.48 crotonaldehyde + NAD+ + H2O - Homo sapiens crotonic acid + NADH - ? 258144 1.2.1.48 decanal + NAD+ + H2O - Homo sapiens decanoic acid + NADH - ? 258116 1.2.1.48 decanal + NAD+ + H2O - Vibrio harveyi decanoic acid + NADH - ? 258116 1.2.1.48 decanal + NAD+ + H2O - Simmondsia chinensis decanoic acid + NADH - ? 258116 1.2.1.48 decanal + NAD+ + H2O - Homo sapiens decanoic acid + NADH + H+ - ? 400814 1.2.1.48 decanal + NAD+ + H2O - Marinobacter nauticus decanoate + NADH + 2 H+ - ? 441268 1.2.1.48 dihydrophytal + NAD+ + H2O - Homo sapiens (3R,S,7R,11R)-3,7,11,15-tetramethylhexadecanoic acid + NADH - ? 258142 1.2.1.48 dodecanal + NAD+ + H2O - Homo sapiens dodecanoic acid + NADH - ? 258134 1.2.1.48 dodecanal + NAD+ + H2O - Simmondsia chinensis dodecanoic acid + NADH - ? 258134 1.2.1.48 dodecanal + NAD+ + H2O best substrate Vibrio harveyi dodecanoic acid + NADH - ? 258134 1.2.1.48 dodecanal + NAD+ + H2O best substrate Simmondsia chinensis dodecanoic acid + NADH - ? 258134 1.2.1.48 dodecanal + NAD+ + H2O - Homo sapiens dodecanoic acid + NADH + H+ - ? 400898 1.2.1.48 dodecanal + NAD+ + H2O 50% of the activity with tetradecanal Geobacillus thermoleovorans dodecanoic acid + NADH + H+ - ? 400898 1.2.1.48 dodecanal + NAD+ + H2O - Marinobacter nauticus dodecanoate + NADH + 2 H+ - ? 461022 1.2.1.48 farnesal + NAD+ + H2O - Homo sapiens farnesoic acid + NADH + H+ - ? 400930 1.2.1.48 glutaraldehyde + NAD+ - Homo sapiens glutaric acid + NADH - ? 258145 1.2.1.48 glyceraldehyde + NAD+ + H2O - Geobacillus thermoleovorans ? - ? 402674 1.2.1.48 heptanal + NAD+ + H2O - Vibrio harveyi heptanoic acid + NADH - ? 258130 1.2.1.48 heptanal + NAD+ + H2O - Homo sapiens heptanoic acid + NADH + H+ - ? 401130 1.2.1.48 hexadecanal + NAD+ + H2O - Homo sapiens hexadecanoic acid + NADH - ? 258137 1.2.1.48 hexadecanal + NAD+ + H2O - Simmondsia chinensis hexadecanoic acid + NADH - ? 258137 1.2.1.48 hexadecanal + NAD+ + H2O high activity Homo sapiens hexadecanoic acid + NADH - ? 258137 1.2.1.48 hexadecanal + NAD+ + H2O - Homo sapiens hexadecanoic acid + NADH + H+ - ? 401137 1.2.1.48 hexadecanal + NAD+ + H2O - Marinobacter nauticus hexadecanoate + NADH + 2 H+ - ? 441443 1.2.1.48 hexadecanal + NAD+ + H2O - Mus musculus hexadecanoate + NADH + 2 H+ - ? 441443 1.2.1.48 hexanal + NAD+ + H2O - Homo sapiens hexanoate + NADH + H+ - ? 189252 1.2.1.48 hexanal + NAD+ + H2O - Geobacillus thermoleovorans ? - ? 402687 1.2.1.48 hexanal + NAD+ + H2O 50% of the activity with tetradecanal Geobacillus thermoleovorans hexanoic acid + NADH + H+ - ? 435525 1.2.1.48 long-chain aldehyde + NAD+ - Homo sapiens ? - ? 370130 1.2.1.48 long-chain aldehyde + NAD+ - Simmondsia chinensis ? - ? 370130 1.2.1.48 long-chain aldehyde + NAD+ mobilization of intracellular wax esters in the cotyledon during germination Simmondsia chinensis ? - ? 370130 1.2.1.48 long-chain aldehyde + NAD+ in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis Yarrowia lipolytica ? - ? 370130 1.2.1.48 long-chain aldehyde + NAD+ in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis Candida tropicalis ? - ? 370130 1.2.1.48 long-chain aldehyde + NAD+ enzyme is a functional part of the bioluminescent system Vibrio harveyi ? - ? 370130 1.2.1.48 long-chain aldehyde + NAD+ the enzyme plays a significant role in n-alkane utilization, especially in intracellular wax ester synthesis Acinetobacter sp. ? - ? 370130 1.2.1.48 long-chain aldehyde + NAD+ in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents Yarrowia lipolytica ? - ? 370130 1.2.1.48 long-chain aldehyde + NAD+ in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents Candida tropicalis ? - ? 370130 1.2.1.48 long-chain aldehyde + NAD+ + H2O - Mus musculus long-chain acid anion + NADH - ? 258126 1.2.1.48 long-chain aldehyde + NAD+ + H2O - Homo sapiens long-chain acid anion + NADH - ? 258126 1.2.1.48 long-chain aldehyde + NAD+ + H2O - Vibrio harveyi long-chain acid anion + NADH - ? 258126 1.2.1.48 long-chain aldehyde + NAD+ + H2O - Yarrowia lipolytica long-chain acid anion + NADH - ? 258126 1.2.1.48 long-chain aldehyde + NAD+ + H2O - Candida albicans long-chain acid anion + NADH - ? 258126 1.2.1.48 long-chain aldehyde + NAD+ + H2O - Candida tropicalis long-chain acid anion + NADH - ? 258126 1.2.1.48 long-chain aldehyde + NAD+ + H2O - Acinetobacter sp. long-chain acid anion + NADH - ? 258126 1.2.1.48 long-chain aldehyde + NAD+ + H2O - Simmondsia chinensis long-chain acid anion + NADH - ? 258126 1.2.1.48 long-chain aldehyde + NAD+ + H2O - Acinetobacter sp. M-1 long-chain acid anion + NADH - ? 258126 1.2.1.48 long-chain aldehyde + NAD+ + H2O - Homo sapiens long-chain carboxylate + NADH - ? 424893 1.2.1.48 long-chain aldehyde + NAD+ + H2O - Rattus norvegicus long-chain carboxylate + NADH - ? 424893 1.2.1.48 m-fluorobenzaldehyde + NAD+ + H2O - Acinetobacter sp. m-fluorobenzoic acid + NADH + H+ - ? 258147 1.2.1.48 m-methylbenzaldehyde + NAD+ + H2O 36% activity toward tetradecanal Acinetobacter sp. m-methylbenzoic acid + NADH - ? 258150 1.2.1.48 additional information not: acetaldehyde Vibrio harveyi ? - ? 89 1.2.1.48 additional information not: acetaldehyde Acinetobacter sp. ? - ? 89 1.2.1.48 additional information not: acetaldehyde Simmondsia chinensis ? - ? 89 1.2.1.48 additional information poor substrates: acetaldehyde, propionaldehyde, crotonaldehyde, glutaraldehyde, benzaldehyde, retinaldehyde Homo sapiens ? - ? 89 1.2.1.48 additional information not: pentanal Vibrio harveyi ? - ? 89 1.2.1.48 additional information not: propionaldehyde Vibrio harveyi ? - ? 89 1.2.1.48 additional information not: propionaldehyde Acinetobacter sp. ? - ? 89 1.2.1.48 additional information Sjögren-Larsson syndrom is an inherited neurocutaneous disease caused by mutations in the ALDH3A2 gene that codes for fatty aldehyde dehydrogenase, an enzyme involved in lipid metabolism. A rich diversity of mutations and haplotype associations is demonstrated in Sjögren-Larsson syndrom Homo sapiens ? - ? 89 1.2.1.48 additional information the enzyme plays an important role in insulin action and is deregulated in states associated with altered insulin signaling Rattus norvegicus ? - ? 89 1.2.1.48 additional information catalytically important residues to be involved in alcohol and aldehyde oxidation are Gln-120, Glu-207, Cys-241, Phe-333, Tyr-410 and His-411 Homo sapiens ? - ? 89 1.2.1.48 additional information enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes Geobacillus thermoleovorans ? - ? 89 1.2.1.48 additional information enzyme displays high activity against aliphatic long-chain aldehydes such as tetradecanal Geobacillus thermoleovorans ? - ? 89 1.2.1.48 additional information the C-terminal gatekeeper helix is important for directing the substrate specificity of FALDH towards long-chain fatty aldehydes. Substrate funnel properties and substrate specificity, overview Homo sapiens ? - ? 89 1.2.1.48 additional information the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes Mus musculus ? - ? 89 1.2.1.48 additional information the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes Mus musculus ? - ? 89 1.2.1.48 additional information enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes Geobacillus thermoleovorans B23 ? - ? 89 1.2.1.48 additional information enzyme displays high activity against aliphatic long-chain aldehydes such as tetradecanal Geobacillus thermoleovorans B23 ? - ? 89 1.2.1.48 additional information not: acetaldehyde Acinetobacter sp. M-1 ? - ? 89 1.2.1.48 additional information not: propionaldehyde Acinetobacter sp. M-1 ? - ? 89 1.2.1.48 nonanal + NAD+ + H2O - Vibrio harveyi nonanoic acid + NADH + H+ - ? 258132 1.2.1.48 o-fluorobenzaldehyde + NAD+ + H2O - Acinetobacter sp. o-fluorobenzoic acid + NADH + H+ - ? 258146 1.2.1.48 octadecanal + NAD+ + H2O - Homo sapiens octadecanoic acid + NADH - ? 258138 1.2.1.48 octadecanal + NAD+ + H2O - Homo sapiens octadecanoic acid + NADH + H+ - ? 401556 1.2.1.48 octadecanal + NADP+ - Homo sapiens octadecanoic acid + NADPH + H+ - r 451456 1.2.1.48 octanal + NAD+ + H2O - Geobacillus thermoleovorans octanoate + NADH + H+ - ? 189254 1.2.1.48 octanal + NAD+ + H2O - Geobacillus thermoleovorans B23 octanoate + NADH + H+ - ? 189254 1.2.1.48 octanal + NAD+ + H2O - Homo sapiens octanoic acid + NADH + H+ - ? 258131 1.2.1.48 octanal + NAD+ + H2O - Vibrio harveyi octanoic acid + NADH + H+ - ? 258131 1.2.1.48 octanal + NAD+ + H2O 50% of the activity with tetradecanal Geobacillus thermoleovorans octanoic acid + NADH + H+ - ? 258131 1.2.1.48 oleyl aldehyde + NAD+ + H2O - Marinobacter nauticus oleate + NADH + 2 H+ - ? 461279 1.2.1.48 p-chlorobenzaldehyde + NAD+ + H2O - Acinetobacter sp. p-chlorobenzoic acid + NADH + H+ - ? 258149 1.2.1.48 p-cumic aldehyde + NAD+ + H2O - Geobacillus thermoleovorans ? - ? 402815 1.2.1.48 p-fluorobenzaldehyde + NAD+ + H2O - Acinetobacter sp. p-fluorobenzoic acid + NADH + H+ - ? 258148 1.2.1.48 palmitoleyl aldehyde + NAD+ + H2O - Marinobacter nauticus palmitoleate + NADH + 2 H+ - ? 461292 1.2.1.48 pentadecanal + NAD+ + H2O - Homo sapiens pentadecanoic acid + NADH - ? 258136 1.2.1.48 pentadecanal + NAD+ + H2O - Cricetulus griseus pentadecanoic acid + NADH + 2 H+ - ? 461298 1.2.1.48 phytenal + NAD+ - Homo sapiens phytenic acid + NADH - ? 371106 1.2.1.48 phytenal + NAD+ the enzyme is involved in the breakdown of phytol Homo sapiens phytenic acid + NADH - ? 371106 1.2.1.48 propionaldehyde + NAD+ + H2O - Homo sapiens propionic acid + NADH - ? 258128 1.2.1.48 pyrenedecanal + NAD+ + H2O - Mus musculus pyrenedecanoic acid + NADH - ? 426969 1.2.1.48 pyrenedecanal + NAD+ + H2O - Homo sapiens pyrenedecanoic acid + NADH - ? 426969 1.2.1.48 pyrenedecanal + NAD+ + H2O - Rattus norvegicus pyrenedecanoic acid + NADH - ? 426969 1.2.1.48 retinal + NAD+ + H2O - Geobacillus thermoleovorans ? - ? 402905 1.2.1.48 tetradecanal + NAD+ + H2O - Homo sapiens tetradecanoic acid + NADH - ? 258135 1.2.1.48 tetradecanal + NAD+ + H2O - Simmondsia chinensis tetradecanoic acid + NADH - ? 258135 1.2.1.48 tetradecanal + NAD+ + H2O highest activity Acinetobacter sp. tetradecanoic acid + NADH - ? 258135 1.2.1.48 tetradecanal + NAD+ + H2O highest activity Acinetobacter sp. M-1 tetradecanoic acid + NADH - ? 258135 1.2.1.48 tetradecanal + NAD+ + H2O - Homo sapiens tetradecanoic acid + NADH + H+ - ? 402001 1.2.1.48 tetradecanal + NAD+ + H2O - Geobacillus thermoleovorans tetradecanoic acid + NADH + H+ - ? 402001 1.2.1.48 tetradecanal + NAD+ + H2O - Marinobacter nauticus tetradecanoate + NADH + 2 H+ - ? 461369 1.2.1.48 tetraeicosanal + NAD+ + H2O - Homo sapiens tetraeicosanoic acid + NADH - ? 258155 1.2.1.48 trans-2-decenal + NAD+ + H2O 32% activity toward tetradecanal Acinetobacter sp. trans-2-decenoic acid + NADH - ? 258151 1.2.1.48 trans-2-hexadecenal + NAD+ + H2O - Homo sapiens trans-2-decenoic acid + NADH - ? 425061 1.2.1.48 trans-cinnamaldehyde + NAD+ + H2O 38% activity toward tetradecanal Acinetobacter sp. trans-cinnamic acid + NADH - ? 258152