1.3.5.2 (S)-dihydroorotate + 1,4-naphthoquinone - Toxoplasma gondii orotate + 1,4-naphthoquinol - ? 425204 1.3.5.2 (S)-dihydroorotate + 1,4-naphthoquinone 50% of the activity with coenzyme Qd Phytophthora infestans orotate + 1,4-naphthoquinol - ? 425204 1.3.5.2 (S)-dihydroorotate + 1,4-naphthoquinone 78% of the activity with coenzyme Qd Solanum tuberosum orotate + 1,4-naphthoquinol - ? 425204 1.3.5.2 (S)-dihydroorotate + 2,3-dimethoxy-5-methyl-1,4-benzoquinone - Toxoplasma gondii orotate + 2,3-dimethoxy-5-methyl-1,4-benzoquinol - ? 425205 1.3.5.2 (S)-dihydroorotate + 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone - Homo sapiens orotate + reduced 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone - ? 438594 1.3.5.2 (S)-dihydroorotate + 2,5-dimethyl-p-benzoquinone - Toxoplasma gondii orotate + 2,5-dimethyl-p-benzoquinol - ? 425206 1.3.5.2 (S)-dihydroorotate + 2,5-dimethyl-p-benzoquinone 48% of the activity with coenzyme Qd Phytophthora infestans orotate + 2,5-dimethyl-p-benzoquinol - ? 425206 1.3.5.2 (S)-dihydroorotate + 2,5-dimethyl-p-benzoquinone 67% of the activity with coenzyme Qd Solanum tuberosum orotate + 2,5-dimethyl-p-benzoquinol - ? 425206 1.3.5.2 (S)-dihydroorotate + 2,6-dichlorophenolindophenol - Toxoplasma gondii orotate + reduced 2,6-dichlorophenolindophenol - ? 395167 1.3.5.2 (S)-dihydroorotate + 2,6-dichlorophenolindophenol - Homo sapiens orotate + reduced 2,6-dichlorophenolindophenol - ? 395167 1.3.5.2 (S)-dihydroorotate + 2,6-dihydrophenolindophenol - Escherichia coli orotate + reduced 2,6-dihydrophenolindophenol - r 453881 1.3.5.2 (S)-dihydroorotate + 2,6-dihydrophenolindophenol - Phytophthora infestans orotate + reduced 2,6-dihydrophenolindophenol - ? 453881 1.3.5.2 (S)-dihydroorotate + 2,6-dihydrophenolindophenol - Solanum tuberosum orotate + reduced 2,6-dihydrophenolindophenol - ? 453881 1.3.5.2 (S)-dihydroorotate + 5,8-dihydroxy-1,4-naphthoquinone 78% of the activity with coenzyme Qd Solanum tuberosum orotate + 5,8-dihydroxy-1,4-naphthoquinol - ? 460359 1.3.5.2 (S)-dihydroorotate + acceptor uses ubiquinone as electron acceptor Escherichia coli orotate + reduced acceptor - ? 258663 1.3.5.2 (S)-dihydroorotate + acceptor fumarate and menadione as electron acceptors Enterococcus faecalis orotate + reduced acceptor - ? 258663 1.3.5.2 (S)-dihydroorotate + acceptor ubiquinone-6 tested as electron acceptor Homo sapiens orotate + reduced acceptor - ? 258663 1.3.5.2 (S)-dihydroorotate + acceptor with ubiquinone-0, 2,6-dichlorophenolindophenol, menadione, decylubiquinone, fumarate and O2 as electron acceptor Escherichia coli orotate + reduced acceptor - ? 258663 1.3.5.2 (S)-dihydroorotate + acceptor with ubiquinone-0, 2,6-dichlorophenolindophenol, menadione, decylubiquinone, fumarate and O2 as electron acceptor Lactococcus lactis orotate + reduced acceptor - ? 258663 1.3.5.2 (S)-dihydroorotate + acceptor fourth step in synthesis of pyrimidine nucleotides Escherichia coli orotate + reduced acceptor - ? 258663 1.3.5.2 (S)-dihydroorotate + acceptor fourth step in synthesis of pyrimidine nucleotides Lactococcus lactis orotate + reduced acceptor - ? 258663 1.3.5.2 (S)-dihydroorotate + acceptor reduction of a number of substrates: fumatate, coenzyme ubiquinone-0 and menadione Enterococcus faecalis orotate + reduced acceptor - ? 258663 1.3.5.2 (S)-dihydroorotate + coenzyme Q - Plasmodium falciparum orotate + reduced coenzyme Q - ? 438035 1.3.5.2 (S)-dihydroorotate + coenzyme Q0 56% of the activity with coenzyme Qd Phytophthora infestans orotate + reduced coenzyme Q0 - ? 460360 1.3.5.2 (S)-dihydroorotate + coenzyme Q0 96% of the activity with coenzyme Qd Solanum tuberosum orotate + reduced coenzyme Q0 - ? 460360 1.3.5.2 (S)-dihydroorotate + coenzyme Q1 111% of the activity with coenzyme Qd Phytophthora infestans orotate + reduced coenzyme Q1 - ? 460362 1.3.5.2 (S)-dihydroorotate + coenzyme Q1 124% of the activity with coenzyme Qd Solanum tuberosum orotate + reduced coenzyme Q1 - ? 460362 1.3.5.2 (S)-dihydroorotate + coenzyme Q10 19% of the activity with coenzyme Qd Solanum tuberosum orotate + reduced coenzyme Q10 - ? 460361 1.3.5.2 (S)-dihydroorotate + coenzyme Q10 30% of the activity with coenzyme Qd Phytophthora infestans orotate + reduced coenzyme Q10 - ? 460361 1.3.5.2 (S)-dihydroorotate + coenzyme Q2 123% of the activity with coenzyme Qd Solanum tuberosum orotate + reduced coenzyme Q2 - ? 460363 1.3.5.2 (S)-dihydroorotate + coenzyme Q6 102% of the activity with coenzyme Qd Solanum tuberosum orotate + reduced coenzyme Q6 - ? 460364 1.3.5.2 (S)-dihydroorotate + coenzyme Q6 144% of the activity with coenzyme Qd Phytophthora infestans orotate + reduced coenzyme Q6 - ? 460364 1.3.5.2 (S)-dihydroorotate + coenzyme Q7 - Bos taurus orotate + reduced coenzyme Q7 - r 451534 1.3.5.2 (S)-dihydroorotate + coenzyme Q9 111% of the activity with coenzyme Qd Solanum tuberosum orotate + reduced coenzyme Q9 - ? 460365 1.3.5.2 (S)-dihydroorotate + coenzyme Q9 66% of the activity with coenzyme Qd Phytophthora infestans orotate + reduced coenzyme Q9 - ? 460365 1.3.5.2 (S)-dihydroorotate + coenzyme Qd - Phytophthora infestans orotate + reduced coenzyme Qd - ? 460366 1.3.5.2 (S)-dihydroorotate + coenzyme Qd - Solanum tuberosum orotate + reduced coenzyme Qd - ? 460366 1.3.5.2 (S)-dihydroorotate + decylubiquinone - Drosophila melanogaster orotate + decylubiquinol - r 425207 1.3.5.2 (S)-dihydroorotate + decylubiquinone - Rattus norvegicus orotate + decylubiquinol - r 425207 1.3.5.2 (S)-dihydroorotate + decylubiquinone - Toxoplasma gondii orotate + decylubiquinol - ? 425207 1.3.5.2 (S)-dihydroorotate + decylubiquinone - Homo sapiens orotate + decylubiquinol - ? 425207 1.3.5.2 (S)-dihydroorotate + decylubiquinone - Homo sapiens orotate + reduced decylubiquinone - ? 438595 1.3.5.2 (S)-dihydroorotate + menadione - Bos taurus orotate + menadiol - r 451531 1.3.5.2 (S)-dihydroorotate + oxidized 2,6-dichloroindophenol - Toxoplasma gondii orotate + reduced 2,6-dichloroindophenol - ? 425208 1.3.5.2 (S)-dihydroorotate + ubiquinone - Cavia porcellus orotate + ubiquinol - ir 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone - Mus musculus orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone - Homo sapiens orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone - Rattus norvegicus orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone - Sus scrofa orotate + ubiquinol - ir 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone - Bos taurus orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone - Bos taurus orotate + ubiquinol - ir 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone decylubiquinone as electron acceptor Homo sapiens orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone ubiquinone-6, ubiquinone-7, ubiquinone-9 and ubiquinone-10 maximize enzyme activity Plasmodium falciparum orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone reaction studied with menadione, O2 and ferricyanide Escherichia coli orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone fourth enzyme in pyrimidine synthesis Mus musculus orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone fourth enzyme in pyrimidine synthesis Mus musculus orotate + ubiquinol - ir 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone fourth enzyme in pyrimidine synthesis Homo sapiens orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone fourth enzyme in pyrimidine synthesis Homo sapiens orotate + ubiquinol - ir 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone fourth enzyme in pyrimidine synthesis Rattus norvegicus orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone fourth enzyme in pyrimidine synthesis Rattus norvegicus orotate + ubiquinol - ir 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone six-step biosynthesis of pyrimidine uridine monophosphate Homo sapiens orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone six-step biosynthesis of pyrimidine uridine monophosphate Rattus norvegicus orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone fourth step in synthesis of uridine 5'-monophosphate Homo sapiens orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone fourth step in synthesis of uridine 5'-monophosphate Plasmodium falciparum orotate + ubiquinol - ? 258665 1.3.5.2 (S)-dihydroorotate + ubiquinone - Rattus norvegicus orotate + reduced ubiquinone - ? 438596 1.3.5.2 (S)-dihydroorotate + ubiquinone-0 - Escherichia coli orotate + ubiquinol - r 451532 1.3.5.2 (S)-dihydroorotate + ubiquinone-0 - Lactococcus lactis orotate + ubiquinol - r 451532 1.3.5.2 (S)-dihydroorotate + ubiquinone-30 - Toxoplasma gondii orotate + ubiquinol-30 - ? 425209 1.3.5.2 (S)-dihydroorotate + ubiquinone-50 - Homo sapiens orotate + ubiquinol-50 - r 425210 1.3.5.2 (S)-dihydroorotate + ubiquinone-50 - Toxoplasma gondii orotate + ubiquinol-50 - ? 425210 1.3.5.2 benzyl-(S)-dihydroorotate + acceptor - Bos taurus benzyl orotate + reduced acceptor - ? 258773 1.3.5.2 dihydroorotate + 2,3-dimethoxy-5-methyl-1,4-benzoquinone - Candida albicans orotate + reduced 2,3-dimethoxy-5-methyl-1,4-benzoquinone - ? 388540 1.3.5.2 dihydroorotate + 2,5-dimethyl-p-benzoquinone 95% the rate of decylubiquinone, wild-type, 75% the rate of decylubiquinone, DELTA1-75 mutant Arabidopsis thaliana orotate + reduced 2,5-dimethyl-p-benzoquinone - ? 373079 1.3.5.2 dihydroorotate + 2,5-dimethylbenzoquinone 84% of the rate with decylubiquinone Drosophila melanogaster orotate + reduced 2,5-dimethylbenzoquinone - ? 373080 1.3.5.2 dihydroorotate + 2,6-dichloroindophenol - Candida albicans orotate + reduced 2,6-dichloroindophenol - ? 388542 1.3.5.2 dihydroorotate + 2,6-dichlorophenolindophenol - Trypanosoma cruzi orotate + reduced 2,6-dichlorophenolindophenol - ? 373082 1.3.5.2 dihydroorotate + 2,6-dichlorophenolindophenol - Homo sapiens orotate + reduced 2,6-dichlorophenolindophenol - ? 373082 1.3.5.2 dihydroorotate + 2,6-dichlorophenolindophenol 33% of the rate with decylubiquinone Drosophila melanogaster orotate + reduced 2,6-dichlorophenolindophenol - ? 373082 1.3.5.2 dihydroorotate + acceptor - Escherichia coli orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor - Homo sapiens orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor - Rattus norvegicus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor - Neurospora crassa orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor - Plasmodium falciparum orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: 2,6-dichlorophenolindophenol Escherichia coli orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: 2,6-dichlorophenolindophenol Rattus norvegicus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: 2,6-dichlorophenolindophenol Neurospora crassa orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptors: e.g. phenazine methosulfate Rattus norvegicus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: menaquinone Escherichia coli orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: quinones Bos taurus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: quinones Neurospora crassa orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: quinones Plasmodium falciparum orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: coenzyme Q6 Bos taurus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor not acceptor: oxygen Bos taurus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor not acceptor: oxygen Neurospora crassa orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor cytochrome b, cytochrome c, pyridine nucleotides (NAD+, NADP+) cannot serve as electron acceptors Neurospora crassa orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: menadione Bos taurus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: menadione Enterococcus faecalis orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor (low activity): 1,4-naphthoquinone, 5,8-hydroxy-naphthoquinone, juglon, plumbagin, polyporic acid Homo sapiens orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor (low activity): 1,4-naphthoquinone, 5,8-hydroxy-naphthoquinone, juglon, plumbagin, polyporic acid Rattus norvegicus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: ubiquinone Escherichia coli orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: ubiquinone Homo sapiens orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: ubiquinone Rattus norvegicus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: ubiquinone Solanum lycopersicum orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: oxygen, slowly Rattus norvegicus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor coenzyme Q7 Bos taurus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor acceptor: fumarate, coenzyme Q10 Enterococcus faecalis orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor reaction intermediates, mechanism, pH-dependence of reaction Escherichia coli orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor mechanism and pH-dependence of reaction Enterococcus faecalis orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor physiological electron acceptor: ubiquinone (aerobic conditions), menaquinone (anaerobic conditions) Escherichia coli orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + acceptor fourth step in pyrimidine biosynthesis Rattus norvegicus orotate + reduced acceptor - ? 258769 1.3.5.2 dihydroorotate + coenzyme Q coenzyme OD possesses a decyl tail Plasmodium falciparum orotate + reduced coenzyme Q - ? 404998 1.3.5.2 dihydroorotate + coenzyme Q0 - Homo sapiens orotate + reduced coenzyme Q0 - ? 461003 1.3.5.2 dihydroorotate + coenzyme Q0 - Schistosoma mansoni orotate + reduced coenzyme Q0 - ? 461003 1.3.5.2 dihydroorotate + coenzyme Q1 coenzyme Q1 possesses a prenyl tail Plasmodium falciparum orotate + reduced coenzyme Q1 - ? 373083 1.3.5.2 dihydroorotate + coenzyme QD coenzyme QD possesses a decyl tail Plasmodium falciparum orotate + reduced coenzyme QD - ? 404999 1.3.5.2 dihydroorotate + CoQ0 102% the rate of decylubiquinone, wild-type, 67% the rate of decylubiquinone, DELTA1-75 mutant Arabidopsis thaliana orotate + reduced CoQo - ? 373084 1.3.5.2 dihydroorotate + decylplastoquinone 78% of the rate with decylubiquinone Drosophila melanogaster orotate + reduced decylplastoquinone - ? 373085 1.3.5.2 dihydroorotate + decylplastoquinone 95% the rate of decylubiquinone, wild-type, 104% the rate of decylubiquinone, DELTA1-75 mutant Arabidopsis thaliana orotate + reduced decylplastoquinone - ? 373085 1.3.5.2 dihydroorotate + decylubiquinone - Drosophila melanogaster orotate + reduced decylubiquinone - ? 373087 1.3.5.2 dihydroorotate + decylubiquinone - Arabidopsis thaliana orotate + reduced decylubiquinone - ? 373087 1.3.5.2 dihydroorotate + decylubiquinone - Candida albicans orotate + reduced decylubiquinone - ? 373087 1.3.5.2 dihydroorotate + decylubiquinone - Eimeria tenella orotate + decylubiquinol - ? 461004 1.3.5.2 dihydroorotate + menadione 39% of the rate with decylubiquinone Drosophila melanogaster orotate + reduced menadione - ? 373090 1.3.5.2 dihydroorotate + menadione 82% the rate of decylubiquinone, wild-type, 78% the rate of decylubiquinone, DELTA1-75 mutant Arabidopsis thaliana orotate + reduced menadione - ? 373090 1.3.5.2 dihydroorotate + O2 - Plasmodium falciparum orotate + H2O2 - ? 373091 1.3.5.2 dihydroorotate + potassium hexacyanoferrate(III) - Candida albicans orotate + reduced potassium hexacyanoferrate(III) - ? 388544 1.3.5.2 dihydroorotate + ubiquinone 30 - Candida albicans orotate + reduced ubiquinone 30 - ? 388545 1.3.5.2 dihydroorotate + ubiquinone 50 - Candida albicans orotate + reduced ubiquinone 50 - ? 388546 1.3.5.2 dihydroorotate + ubiquinone-0 80% of the rate with decylubiquinone Drosophila melanogaster orotate + reduced ubiquinone-0 - ? 373093 1.3.5.2 dihydroorotate + ubiquinone-10 59% of the rate with decylubiquinone Drosophila melanogaster orotate + reduced ubiquinone-10 - ? 373095 1.3.5.2 dihydroorotate + ubiquinone-50 83% the rate of decylubiquinone, wild-type, 76% the rate of decylubiquinone, DELTA1-75 mutant Arabidopsis thaliana orotate + reduced ubiquinone-50 - ? 373097 1.3.5.2 ethyl-dihydroorotate + acceptor - Bos taurus ethyl-orotate + reduced acceptor - ? 258771 1.3.5.2 L-dihydroorotate + 2,6-dichloroindophenol - Plasmodium falciparum orotate + ? - ? 373565 1.3.5.2 L-dihydroorotate + 2,6-dichlorophenolindophenol - Escherichia coli orotate + reduced 2,6-dichlorophenolindophenol - ? 373566 1.3.5.2 L-dihydroorotate + 2,6-dihydrophenolindophenol - Rattus norvegicus orotate + reduced 2,6-dihydrophenolindophenol - r 451530 1.3.5.2 L-dihydroorotate + decylubiquinone - Plasmodium falciparum orotate + ? - ? 373568 1.3.5.2 L-dihydroorotate + decylubiquinone - Homo sapiens orotate + reduced decylubiquinone - ? 373569 1.3.5.2 L-dihydroorotate + decylubiquinone - Plasmodium falciparum orotate + reduced decylubiquinone - ? 373569 1.3.5.2 L-dihydroorotate + FMN - Homo sapiens orotate + FMNH2 - ? 413428 1.3.5.2 L-dihydroorotate + FMN - Plasmodium falciparum orotate + FMNH2 - ? 413428 1.3.5.2 L-dihydroorotate + FMN DHODH catalyzes the FMN-dependent oxidation of dihydroorotate to produce orotic acid. Two separate half reactions are required to complete the catalytic cycle: 1. oxidation of dihydroorotate driven by the reduction of FMN and, 2. reoxidation of FMNH2 to regenerate the active enzyme Homo sapiens orotate + FMNH2 - ? 413428 1.3.5.2 L-dihydroorotate + FMN DHODH catalyzes the FMN-dependent oxidation of dihydroorotate to produce orotic acid. Two separate half reactions are required to complete the catalytic cycle: 1. oxidation of dihydroorotate driven by the reduction of FMN and, 2. reoxidation of FMNH2 to regenerate the active enzyme Plasmodium falciparum orotate + FMNH2 - ? 413428 1.3.5.2 L-dihydroorotate + ubiquinone-0 - Plasmodium falciparum orotate + reduced ubiquinone-0 - ? 373570 1.3.5.2 L-dihydroorotate + ubiquinone-4 - Plasmodium falciparum orotate + reduced ubiquinone-4 - ? 373571 1.3.5.2 L-dihydroorotate + ubiquinone-6 - Homo sapiens orotate + reduced ubiquinone-6 - ? 373572 1.3.5.2 L-dihydroorotate + ubiquinone-6 - Bos taurus orotate + reduced ubiquinone-6 - ? 373572 1.3.5.2 L-dihydroorotate + ubiquinone-6 - Plasmodium falciparum orotate + reduced ubiquinone-6 - ? 373572 1.3.5.2 L-dihydroorotate + vitamin K3 - Plasmodium falciparum orotate + reduced vitamin K3 - ? 373573 1.3.5.2 methyl-dihydroorotate + acceptor - Bos taurus methyl-orotate + reduced acceptor - ? 258770 1.3.5.2 methyl-S-dihydroorotate + 2,6-dichlorophenolindophenol - Bos taurus methylorotate + reduced 2,6-dichlorophenolindophenol - r 451535 1.3.5.2 additional information not substrate: 1-methyl-(S)-dihydroorotate, 3-methyl-dihydroorotate, 1,3-dimethyldihydroorotate Bos taurus ? - ? 89 1.3.5.2 additional information enzyme has methylviologen-fumarate reductase activity Trypanosoma cruzi ? - ? 89 1.3.5.2 additional information computational method to investigate potential proton relay pathways in the active site of the enzyme Homo sapiens ? - ? 89 1.3.5.2 additional information fumarate and NAD are inadequate electron acceptors for full-length DHODH and N-terminally truncated DHODH Candida albicans ? - ? 89 1.3.5.2 additional information fumarate is a poor electron acceptor Toxoplasma gondii ? - ? 89 1.3.5.2 additional information reduction of decylubiquinone (DUQ) is stoichiometrically equivalent to reduction of 2,6-ichloroindophenol (DCIP) resulting in the decrease in absorbance at 610 nm, which is measured Homo sapiens ? - - 89 1.3.5.2 tert-butyl-dihydroorotate + acceptor - Bos taurus tert-butyl-orotate + reduced acceptor - ? 258772