1.8.1.B1	2 GSH + NADP+	-	Schistosoma japonicum	GSSG + NADPH + H+	-	?	424825	
1.8.1.B1	2-hydroxyethyl disulfide + NADPH + H+	-	Schistosoma japonicum	?	-	?	425429	
1.8.1.B1	5,5'-dithio-bis(2-nitrobenzoic acid) + NADPH + H+	-	Echinococcus granulosus	5'-thionitrobenzoic acid + NADP+	-	?	425789	
1.8.1.B1	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH	-	Echinococcus granulosus	2-nitro-5-thiobenzoate + NADP+	-	?	260484	
1.8.1.B1	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH	-	Schistosoma mansoni	?	-	?	395983	
1.8.1.B1	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+	-	Schistosoma mansoni	2-nitro-5-thiobenzoate + NADP+	-	?	395980	
1.8.1.B1	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+	-	Schistosoma japonicum	2-nitro-5-thiobenzoate + NADP+	-	?	395980	
1.8.1.B1	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+	-	Echinococcus granulosus	2-nitro-5-thiobenzoate + NADP+	-	?	395980	
1.8.1.B1	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+	-	Taenia crassiceps	2-nitro-5-thiobenzoate + NADP+	-	?	395980	
1.8.1.B1	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+	-	Taenia solium	2-nitro-5-thiobenzoate + NADP+	-	?	395980	
1.8.1.B1	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+	-	Fasciola gigantica	2-nitro-5-thiobenzoate + NADP+	-	?	395980	
1.8.1.B1	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+	-	Fasciola hepatica	2-nitro-5-thiobenzoate + NADP+	-	?	395980	
1.8.1.B1	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+	absolute specificity for NADPH as electron donor	Taenia crassiceps	2-nitro-5-thiobenzoate + NADP+	-	?	395980	
1.8.1.B1	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+	-	Mus musculus	?	-	?	395982	
1.8.1.B1	beta-hydroxyethyl disulfide + NADPH + H+	-	Fasciola gigantica	2 2-sulfanylethan-1-ol + NADP+	-	?	441133	
1.8.1.B1	cytosolic thioredoxin + NADP+	-	Echinococcus granulosus	cytosolic thioredoxin disulfide + NADPH	-	r	451774	
1.8.1.B1	glutaredoxin + NADPH + H+	-	Schistosoma japonicum	?	-	?	426447	
1.8.1.B1	glutathione disulfide + NADPH + H+	-	Mus musculus	glutathione + NADP+	-	?	388833	
1.8.1.B1	glutathione disulfide + NADPH + H+	-	Echinococcus granulosus	glutathione + NADP+	-	?	388833	
1.8.1.B1	glutathione disulfide + NADPH + H+	-	Schistosoma mansoni	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	-	Schistosoma japonicum	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	-	Taenia crassiceps	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	-	Taenia solium	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	-	Schistosoma haematobium	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	-	Fasciola gigantica	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	-	Echinococcus granulosus	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	-	Homo sapiens	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	-	Opisthorchis viverrini	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	enzyme displays hysteretic behavior	Fasciola gigantica	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	the enzyme of the parasite essential for the survival of schistosomes in the mammalian host	Schistosoma mansoni	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	the enzyme plays an essential role in maintaining the redox homeostasis and antioxidant defenses in the parasite Fasciola gigantica. Parasitic flukes have a limited set of antioxidant proteins in contrast to their mammalian hosts. In platyhelminthic parasites, the two systems (glutathione/glutaredoxin system and thioredoxin system) are replaced by a single system of a multifunctional flavin containing chimeric selenoenzyme known as thioredoxin glutathione reductase, which donates electrons to both thioredoxin disulfide and glutathione disulfide in these parasites	Fasciola gigantica	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione disulfide + NADPH + H+	the enzyme follows a two-site ping-pong bi bi kinetic mechanism, in which both substrates and products are bound in rapid equilibrium fashion	Taenia crassiceps	2 glutathione + NADP+	-	?	441419	
1.8.1.B1	glutathione-hydroxyethyl disulfide + NADPH + H+	-	Taenia solium	glutathione + 2-sulfanylethan-1-ol + NADP+	-	?	441420	
1.8.1.B1	GSSG + NADPH + H+	-	Schistosoma mansoni	glutathione + NADP+	-	?	388854	
1.8.1.B1	GSSG + NADPH + H+	absolute specificity for NADPH as electron donor	Taenia crassiceps	glutathione + NADP+	-	?	388854	
1.8.1.B1	GSSG + NADPH + H+	-	Drosophila melanogaster	GSH + NADP+	-	?	397363	
1.8.1.B1	GSSG + NADPH + H+	-	Schistosoma mansoni	GSH + NADP+	-	?	397363	
1.8.1.B1	GSSG + NADPH + H+	-	Schistosoma japonicum	GSH + NADP+	-	?	397363	
1.8.1.B1	GSSG + NADPH + H+	-	Echinococcus granulosus	GSH + NADP+	-	?	397363	
1.8.1.B1	GSSG + NADPH + H+	-	Taenia crassiceps	GSH + NADP+	-	?	397363	
1.8.1.B1	GSSG + NADPH + H+	-	Mus musculus	GSH + NADP+	-	?	397363	
1.8.1.B1	GSSG + NADPH + H+	-	Fasciola hepatica	GSH + NADP+	-	?	397363	
1.8.1.B1	hydroxyethyl disulfide + NADPH + H+	-	Taenia crassiceps	?	-	?	426490	
1.8.1.B1	insulin disulfide + NADPH + H+	-	Taenia solium	insulin + NADP+	-	?	441476	
1.8.1.B1	mitochondrial thioredoxin + NADP+	-	Echinococcus granulosus	mitochondrial thioredoxin disulfide + NADPH	-	r	451775	
1.8.1.B1	additional information	the parasite-specific enzyme thioredoxin glutathione reductase is a component of the defense system	Schistosoma mansoni	?	-	?	89	
1.8.1.B1	additional information	TGR promotes isomerization of disulfide bonds formed between glutathione peroxidase 4 and certain sperm proteins, generating a 46-kDa species containing glutathione peroxidase 4 from high molecular weight nonspecific cross-links	Mus musculus	?	-	?	89	
1.8.1.B1	additional information	the glutathione reductase activity of TGR exhibits hysteretic behavior regulated by the [GSSG]/[GSH] ratio. This behavior is associated with glutathionylation by GSSG and abolished by deglutathionylation	Echinococcus granulosus	?	-	?	89	
1.8.1.B1	additional information	low catalytic efficiency with H2O2	Taenia crassiceps	?	-	?	89	
1.8.1.B1	oxidized insulin + NADPH + H+	-	Fasciola gigantica	reduced insulin + NADP+	-	?	441832	
1.8.1.B1	thioredoxin + NADP+	-	Schistosoma mansoni	thioredoxin disulfide + NADPH	-	?	260477	
1.8.1.B1	thioredoxin + NADP+	-	Schistosoma japonicum	thioredoxin disulfide + NADPH + H+	-	?	260478	
1.8.1.B1	thioredoxin + NADP+	-	Echinococcus granulosus	thioredoxin disulfide + NADPH + H+	-	?	260478	
1.8.1.B1	thioredoxin disulfide + NADPH	absolute specificity for NADPH as electron donor	Taenia crassiceps	thioredoxin + NADP+	-	?	377877	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	-	Drosophila melanogaster	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	-	Mus musculus	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	-	Schistosoma mansoni	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	-	Schistosoma japonicum	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	-	Echinococcus granulosus	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	-	Taenia crassiceps	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	-	Schistosoma haematobium	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	-	Fasciola gigantica	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	-	Homo sapiens	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	-	Fasciola hepatica	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	-	Opisthorchis viverrini	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	Escherichia coli thioredoxin disulfide	Taenia solium	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	the enzyme of the parasite essential for the survival of schistosomes in the mammalian host	Schistosoma mansoni	thioredoxin + NADP+	-	?	395001	
1.8.1.B1	thioredoxin disulfide + NADPH + H+	the enzyme follows a two-site ping-pong bi bi kinetic mechanism, in which both substrates and products are bound in rapid equilibrium fashion	Taenia crassiceps	thioredoxin + NADP+	-	?	395001