1.1.1.358 1-methylisatin + NADPH + H+ 86% of the activity compared to isatin Candida parapsilosis ? - ? 422266 1.1.1.358 2-dehydropantolactone + NADPH + H+ - Candida parapsilosis (R)-pantolactone + NADP+ - ir 421794 1.1.1.358 2-dehydropantolactone + NADPH + H+ - Candida parapsilosis (R)-pantolactone + NADP+ - ? 421794 1.1.1.358 2-dehydropantolactone + NADPH + H+ - Candida dubliniensis (R)-pantolactone + NADP+ - ? 421794 1.1.1.358 2-dehydropantolactone + NADPH + H+ - Candida orthopsilosis (R)-pantolactone + NADP+ - ? 421794 1.1.1.358 2-dehydropantolactone + NADPH + H+ 69% of the activity compared to isatin. The stereospecificity for NADPH is not known. Activity with NADH is 2% compared to the activity with NADPH Candida parapsilosis (R)-pantolactone + NADP+ - ir 421794 1.1.1.358 2-dehydropantolactone + NADPH + H+ recombinant CorCPR exhibited a high catalytic activity for the synthesis of (R)-pantolactone ((R)-PL) from 2-dehydropantolactone (KPL). The activity assay is performed using purified CorCPR and crude recombinant GDH in a single batch reaction. GDH is used to complete the enzyme-coupled NADPH regeneration system. CPR-01 form Candida orthopsilosis Co 90-125 exhibits excellent enantioselectivity (enantiomeric excess of over 99%). CorCPR exhibits the highest activity and stereoselectivity toward KPL Candida orthopsilosis (R)-pantolactone + NADP+ - ? 421794 1.1.1.358 2-dehydropantolactone + NADPH + H+ - Candida dubliniensis ATCC MYA-646 (R)-pantolactone + NADP+ - ? 421794 1.1.1.358 2-dehydropantolactone + NADPH + H+ - Candida dubliniensis CD36 (R)-pantolactone + NADP+ - ? 421794 1.1.1.358 2-dehydropantolactone + NADPH + H+ - Candida orthopsilosis Co 90-125 (R)-pantolactone + NADP+ - ? 421794