2.4.1.210 additional information - at an acidic pH the D-ring of the substrate that should be in an open form is closed and glycosylation does not occur. The decrease in activity at acidic pH also indicates that an essential residue participates in catalytic functioning while in the unprotonated state 722071 2.4.1.210 5.5 9.5 activity range 722071 2.4.1.210 6.5 9 - 288690 2.4.1.210 6.5 9.5 pH 6.5: about 70% of maximal activity, pH 9.5: about 55% of maximal activity 658786