1.14.14.73 albendazole monooxygenase (sulfoxide-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24058654&form=6&db=m Inducible CYP2J2 and Its Product 11,12-EET Promotes Bacterial Phagocytosis: A Role for CYP2J2 Deficiency in the Pathogenesis of Crohn's Disease? causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 1.14.14.73 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25796175&form=6&db=m CYP2J2 rs890293 polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese Han population. unassigned - 1.14.14.73 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27396818&form=6&db=m Gene- gene interaction between CYP2J2 and PPAR -? gene on late-onset Alzheimer's disease in the eastern Chinese Han population. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 1.14.14.73 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23446230&form=6&db=m CYP2J2 Overexpression Increases EETs and Protects against Angiotensin II-Induced Abdominal Aortic Aneurysm in Mice. therapeutic application,unassigned 1,0 1.14.14.73 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24023684&form=6&db=m CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy. causal interaction,therapeutic application,unassigned 1,2,0 1.14.14.73 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475630&form=6&db=m Promoter polymorphism G-50T of a human CYP2J2 epoxygenase gene is associated with common susceptibility to asthma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 1.14.14.73 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17429317&form=6&db=m CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 1.14.14.73 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26859195&form=6&db=m CYP2J2 Overexpression Increases EETs and Protects Against HFD-induced Atherosclerosis in ApoE-/- Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 1.14.14.73 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28000856&form=6&db=m CYP2J2 participates in atherogenesis by mediating cell proliferation, migration and foam cell formation. ongoing research,unassigned 4,0 1.14.14.73 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23041291&form=6&db=m Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 1.14.14.73 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23041291&form=6&db=m Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 1.14.14.73 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720933&form=6&db=m Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 1.14.14.73 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28756208&form=6&db=m Activation of ALDH1A1 in MDA-MB-468 breast cancer cells that over-express CYP2J2 protects against paclitaxel-dependent cell death mediated by reactive oxygen species. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 1.14.14.73 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32354111&form=6&db=m In-Depth Characterization of EpiIntestinal Microtissue as a Model for Intestinal Drug Absorption and Metabolism in Human. therapeutic application,unassigned 2,0 1.14.14.73 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32920985&form=6&db=m Impact of gene polymorphisms in drug-metabolizing enzymes and transporters on trough concentrations of rivaroxaban in patients with atrial fibrillation. ongoing research,unassigned 2,0 1.14.14.73 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30525564&form=6&db=m A molecular design strategy to construct the near-infrared fluorescent probe for selectively sensing human cytochrome P450 2J2. diagnostic usage,therapeutic application,unassigned 3,2,0 1.14.14.73 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930289&form=6&db=m Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.14.73 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638876&form=6&db=m Cytochrome p450 epoxygenase promotes human cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.14.73 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19550113&form=6&db=m Expression of cytochrome P450 arachidonic acid epoxygenase 2J2 in human tumor tissues and cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.14.73 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21656078&form=6&db=m The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 1.14.14.73 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24788058&form=6&db=m Potential of decursin to inhibit the human cytochrome P450 2J2 isoform. causal interaction,ongoing research,unassigned 3,2,0 1.14.14.73 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28160853&form=6&db=m Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 1.14.14.73 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29655687&form=6&db=m The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation. causal interaction,ongoing research,unassigned 1,3,0 1.14.14.73 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34258261&form=6&db=m CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 1.14.14.73 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28030819&form=6&db=m Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation. causal interaction,unassigned 3,0 1.14.14.73 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28160853&form=6&db=m Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 1.14.14.73 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29098037&form=6&db=m Role of cytochrome P450 2J2 on cell proliferation and resistance to an anticancer agent in hepatocellular carcinoma HepG2 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 1.14.14.73 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33312341&form=6&db=m 6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 1.14.14.73 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33437370&form=6&db=m CYP2J2 promotes the development of hepatocellular carcinoma by increasing the EETs production to improve HIF-1? stability. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 1.14.14.73 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21656078&form=6&db=m The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 1.14.14.73 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23696562&form=6&db=m Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 1.14.14.73 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24023684&form=6&db=m CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy. causal interaction,therapeutic application,unassigned 1,2,0 1.14.14.73 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27416746&form=6&db=m CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.14.73 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734152&form=6&db=m Epoxyeicosatrienoic acid prevents maladaptive remodeling in pressure overload by targeting calcineurin/NFAT and Smad-7. therapeutic application,unassigned 1,0 1.14.14.73 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32210298&form=6&db=m CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes. causal interaction,unassigned 4,0 1.14.14.73 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19429816&form=6&db=m Overexpression of CYP2J2 Provides Protection against Doxorubicin Induced Cardiotoxicity. causal interaction,therapeutic application,unassigned 2,2,0 1.14.14.73 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24021950&form=6&db=m Activity, Inhibition and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes. ongoing research,therapeutic application,unassigned 3,2,0 1.14.14.73 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29343610&form=6&db=m CYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species Toxicity. causal interaction,therapeutic application,unassigned 1,4,0 1.14.14.73 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29629756&form=6&db=m An Emerging Pathway of Doxorubicin Cardiotoxicity Mediated through CYP2J2. therapeutic application,unassigned 1,0 1.14.14.73 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29695613&form=6&db=m Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 1.14.14.73 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21477627&form=6&db=m The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.73 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450017&form=6&db=m CYP2J2 epoxygenase membrane anchor plays an important role in facilitating electron transfer from CPR. causal interaction,unassigned 1,0 1.14.14.73 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29966295&form=6&db=m Regulation of CYP2J2 and EET Levels in Cardiac Disease and Diabetes. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 1.14.14.73 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31902555&form=6&db=m Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 1.14.14.73 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33716791&form=6&db=m The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.73 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29580941&form=6&db=m Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 1.14.14.73 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31249444&form=6&db=m Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis. causal interaction,ongoing research,unassigned 3,3,0 1.14.14.73 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34162680&form=6&db=m Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3 1.14.14.73 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466638&form=6&db=m Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. causal interaction,diagnostic usage,unassigned 3,1,0 1.14.14.73 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16839864&form=6&db=m Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 1.14.14.73 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21476972&form=6&db=m The Roles of Cytochrome P450 in Ischemic Heart Diseas. causal interaction,unassigned 4,0 1.14.14.73 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21642892&form=6&db=m Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 1.14.14.73 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23647230&form=6&db=m Structural basis for the mutation-induced dysfunction of human CYP2J2: a computational study. causal interaction,unassigned 3,0 1.14.14.73 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684773&form=6&db=m A novel polymorphism of the CYP2J2 gene is associated with coronary artery disease in Uygur population in China. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 1.14.14.73 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25204827&form=6&db=m Research/review: Insights into the mutation-induced dysfunction of arachidonic acid metabolism from modeling of human CYP2J2. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.73 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26404779&form=6&db=m Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.14.14.73 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28938665&form=6&db=m Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 1.14.14.73 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31000184&form=6&db=m Role of cytochrome epoxygenase (CYP2J2) in the pathophysiology of coronary artery disease in South Indian population. ongoing research,unassigned 4,0 1.14.14.73 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17327508&form=6&db=m The -50G>T polymorphism in the promoter of the CYP2J2 gene in coronary heart disease: the Ludwigshafen Risk and Cardiovascular Health study. ongoing research,unassigned 2,0 1.14.14.73 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17429317&form=6&db=m CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 1.14.14.73 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24148690&form=6&db=m The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. causal interaction,unassigned 3,0 1.14.14.73 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24058654&form=6&db=m Inducible CYP2J2 and Its Product 11,12-EET Promotes Bacterial Phagocytosis: A Role for CYP2J2 Deficiency in the Pathogenesis of Crohn's Disease? causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 1.14.14.73 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20140850&form=6&db=m Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 1.14.14.73 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23696562&form=6&db=m Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 1.14.14.73 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21742052&form=6&db=m Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice. ongoing research,therapeutic application,unassigned 4,2,0 1.14.14.73 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33239900&form=6&db=m The Human Genetic Variants CYP2J2 rs2280275 and EPHX2 rs751141 and Risk of Diabetic Nephropathy in Egyptian Type 2 Diabetic Patients. ongoing research,unassigned 2,0 1.14.14.73 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34501433&form=6&db=m Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 1.14.14.73 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25389363&form=6&db=m CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPAR?. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.14.73 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17286575&form=6&db=m Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 1.14.14.73 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18219097&form=6&db=m A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 1.14.14.73 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26404779&form=6&db=m Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.14.14.73 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31295013&form=6&db=m The effects of endothelium-specific CYP2J2 overexpression on the attenuation of retinal ganglion cell apoptosis in a glaucoma rat model. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 1.14.14.73 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31671426&form=6&db=m Berberine Induces CYP2J2 Expression in Human U251 Glioma Cells via Regulation of Peroxisome Proliferator-Activated Receptor Alpha. causal interaction,ongoing research,unassigned 4,4,0 1.14.14.73 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330047&form=6&db=m Targeting CYP2J2 to Enhance the Anti-Glioma Efficacy of Cannabinoid Receptor 2 Stimulation by Inhibiting the Pro-Angiogenesis Function of M2 Microglia. unassigned - 1.14.14.73 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28440284&form=6&db=m CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue. ongoing research,unassigned 1,0 1.14.14.73 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29966295&form=6&db=m Regulation of CYP2J2 and EET Levels in Cardiac Disease and Diabetes. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 1.14.14.73 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22223859&form=6&db=m Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-?-induced injury. causal interaction,unassigned 4,0 1.14.14.73 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24145329&form=6&db=m CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure. ongoing research,therapeutic application,unassigned 4,1,0 1.14.14.73 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27416746&form=6&db=m CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.14.73 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30219518&form=6&db=m Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 1.14.14.73 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32210298&form=6&db=m CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes. causal interaction,unassigned 4,0 1.14.14.73 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33716791&form=6&db=m The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.73 Hematologic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21030485&form=6&db=m CYP2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.14.73 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25601761&form=6&db=m Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 1.14.14.73 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28328948&form=6&db=m Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice. causal interaction,ongoing research,unassigned 1,2,0 1.14.14.73 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28030819&form=6&db=m Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation. causal interaction,unassigned 3,0 1.14.14.73 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26053032&form=6&db=m CYP2J2 overexpression ameliorates hyperlipidemia via increased fatty acid oxidation mediated by the AMPK pathway. ongoing research,unassigned 4,0 1.14.14.73 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15864120&form=6&db=m Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.14.73 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17286575&form=6&db=m Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 1.14.14.73 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18219097&form=6&db=m A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 1.14.14.73 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22173545&form=6&db=m Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation? causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 1.14.14.73 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22731644&form=6&db=m CYP2J2 -50 G/T and ADRB2 G46A Gene Polymorphisms in Saudi Subjects with Hypertension. diagnostic usage,ongoing research,unassigned 1,1,0 1.14.14.73 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23647230&form=6&db=m Structural basis for the mutation-induced dysfunction of human CYP2J2: a computational study. causal interaction,unassigned 3,0 1.14.14.73 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26105280&form=6&db=m OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia. causal interaction,ongoing research,unassigned 4,4,0 1.14.14.73 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27286171&form=6&db=m CYP2J2 - regulation, function and polymorphism. causal interaction,therapeutic application,unassigned 3,1,0 1.14.14.73 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30518987&form=6&db=m A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk. causal interaction,ongoing research,unassigned 3,2,0 1.14.14.73 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33716791&form=6&db=m The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.73 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20118222&form=6&db=m Gene Delivery of a Cytochrome P450 Epoxygenase Ameliorates Monocrotaline-induced Pulmonary Artery Hypertension in Rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.14.73 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26902473&form=6&db=m Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium. ongoing research,therapeutic application,unassigned 4,1,0 1.14.14.73 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28000856&form=6&db=m CYP2J2 participates in atherogenesis by mediating cell proliferation, migration and foam cell formation. ongoing research,unassigned 4,0 1.14.14.73 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20140850&form=6&db=m Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 1.14.14.73 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23696562&form=6&db=m Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 1.14.14.73 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25389363&form=6&db=m CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPAR?. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.14.73 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27286171&form=6&db=m CYP2J2 - regulation, function and polymorphism. causal interaction,therapeutic application,unassigned 3,1,0 1.14.14.73 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28440284&form=6&db=m CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue. ongoing research,unassigned 1,0 1.14.14.73 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29318723&form=6&db=m Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 1.14.14.73 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18496133&form=6&db=m Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 1.14.14.73 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26221386&form=6&db=m Association of CYP2J2 gene polymorphisms with ischemic stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.14.73 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28272236&form=6&db=m Association of CYP2J2 gene polymorphisms with ischemic stroke and stroke subtypes in Chinese population. causal interaction,therapeutic application,unassigned 3,1,0 1.14.14.73 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29046152&form=6&db=m Cerebral Small Vessel Disease is Associated with Genetic Variations in CYP2J. causal interaction,unassigned 4,0 1.14.14.73 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22260463&form=6&db=m Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6 nephrectomized rat via inhibition of apoptosis and fibrosis. ongoing research,unassigned 4,0 1.14.14.73 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21030485&form=6&db=m CYP2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.14.73 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21477627&form=6&db=m The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.73 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25389366&form=6&db=m CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.14.73 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33215946&form=6&db=m The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury. ongoing research,unassigned 1,0 1.14.14.73 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31132075&form=6&db=m Associations between CYP2J2 (-76G>T) rs890293 polymorphism and age-related macular degeneration. unassigned - 1.14.14.73 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18496133&form=6&db=m Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 1.14.14.73 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19105833&form=6&db=m The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 1.14.14.73 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20597138&form=6&db=m Haplotype analysis of the CYP2J2 gene associated with myocardial infarction in a Chinese Han population. unassigned - 1.14.14.73 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25560582&form=6&db=m Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population. unassigned - 1.14.14.73 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33716791&form=6&db=m The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.73 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29911373&form=6&db=m [Research progress of human cytochrome P450 2J2 and its ligands]. causal interaction,therapeutic application,unassigned 1,1,0 1.14.14.73 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33437370&form=6&db=m CYP2J2 promotes the development of hepatocellular carcinoma by increasing the EETs production to improve HIF-1? stability. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 1.14.14.73 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34162680&form=6&db=m Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930289&form=6&db=m Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16495056&form=6&db=m Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2. causal interaction,therapeutic application,unassigned 4,3,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638876&form=6&db=m Cytochrome p450 epoxygenase promotes human cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908963&form=6&db=m Comparative Analysis of Peritoneum and Tumor Eicosanoids and Pathways in Advanced Ovarian Cancer. causal interaction,unassigned 1,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289568&form=6&db=m Selective Inhibitors of CYP2J2 Related to Terfenadine Exhibit Activity Strongly against Human Cancers in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19550113&form=6&db=m Expression of cytochrome P450 arachidonic acid epoxygenase 2J2 in human tumor tissues and cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21030485&form=6&db=m CYP2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21477627&form=6&db=m The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases. causal interaction,therapeutic application,unassigned 3,4,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21656078&form=6&db=m The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21846841&form=6&db=m Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species level, Mitochondrial Dysfunction, Caspase Activation and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide. ongoing research,unassigned 3,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22223859&form=6&db=m Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-?-induced injury. causal interaction,unassigned 4,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22761738&form=6&db=m Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2. ongoing research,unassigned 3,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23688135&form=6&db=m CYP epoxygenase derived EETs: from cardiovascular protection to human cancer therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23865864&form=6&db=m Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance. causal interaction,ongoing research,unassigned 4,2,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24788058&form=6&db=m Potential of decursin to inhibit the human cytochrome P450 2J2 isoform. causal interaction,ongoing research,unassigned 3,2,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26105280&form=6&db=m OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia. causal interaction,ongoing research,unassigned 4,4,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720933&form=6&db=m Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28030819&form=6&db=m Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation. causal interaction,unassigned 3,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28160853&form=6&db=m Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28237650&form=6&db=m Inhibition and inactivation of human CYP2J2: Implications in cardiac pathophysiology and opportunities in cancer therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29098037&form=6&db=m Role of cytochrome P450 2J2 on cell proliferation and resistance to an anticancer agent in hepatocellular carcinoma HepG2 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29433675&form=6&db=m Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme. causal interaction,therapeutic application,unassigned 3,3,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29655687&form=6&db=m The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation. causal interaction,ongoing research,unassigned 1,3,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29911373&form=6&db=m [Research progress of human cytochrome P450 2J2 and its ligands]. causal interaction,therapeutic application,unassigned 1,1,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30525564&form=6&db=m A molecular design strategy to construct the near-infrared fluorescent probe for selectively sensing human cytochrome P450 2J2. diagnostic usage,therapeutic application,unassigned 3,2,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30532780&form=6&db=m Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32305498&form=6&db=m Cytochrome P450 Epoxygenase 2J2 Protects Against Lung Ischemia/Reperfusion Injury by Activating the P13K/Akt/GSK-3-?/NF-kB Signaling Pathway During Deep Hypothermic Low Flow in Mice. unassigned - 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32681429&form=6&db=m Altered expression of cytochrome P450 enzymes involved in metabolism of androgens and vitamin D in the prostate as a risk factor for prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33682565&form=6&db=m The development of novel cytochrome P450 2J2 (CYP2J2) inhibitor and the underlying interaction between inhibitor and CYP2J2. causal interaction,therapeutic application,unassigned 4,1,0 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34162680&form=6&db=m Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3 1.14.14.73 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34258261&form=6&db=m CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 1.14.14.73 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25389366&form=6&db=m CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.14.73 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20140850&form=6&db=m Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 1.14.14.73 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28440284&form=6&db=m CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue. ongoing research,unassigned 1,0 1.14.14.73 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29318723&form=6&db=m Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 1.14.14.73 Obesity, Maternal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30398904&form=6&db=m Role of pregnancy and obesity on vitamin D status, transport, and metabolism in baboons. causal interaction,unassigned 1,0 1.14.14.73 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26105280&form=6&db=m OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia. causal interaction,ongoing research,unassigned 4,4,0 1.14.14.73 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27115337&form=6&db=m Increased epoxyeicosatrienoic acids and reduced soluble epoxide hydrolase expression in the preeclamptic placenta. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 1.14.14.73 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20495177&form=6&db=m Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. ongoing research,unassigned 2,0 1.14.14.73 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31902555&form=6&db=m Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 1.14.14.73 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29850024&form=6&db=m Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease. causal interaction,ongoing research,unassigned 3,4,0 1.14.14.73 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32224017&form=6&db=m Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 1.14.14.73 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15581597&form=6&db=m Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids. therapeutic application,unassigned 2,0 1.14.14.73 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21656078&form=6&db=m The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 1.14.14.73 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18496133&form=6&db=m Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 1.14.14.73 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26221386&form=6&db=m Association of CYP2J2 gene polymorphisms with ischemic stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.14.73 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28272236&form=6&db=m Association of CYP2J2 gene polymorphisms with ischemic stroke and stroke subtypes in Chinese population. causal interaction,therapeutic application,unassigned 3,1,0 1.14.14.73 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720933&form=6&db=m Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 1.14.14.73 Varicose Veins http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15191401&form=6&db=m Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0