1.4.3.5 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15772097&form=6&db=m Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase. causal interaction,therapeutic application,unassigned 3,4,0 1.4.3.5 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16538088&form=6&db=m Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment. causal interaction,unassigned 3,0 1.4.3.5 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759001&form=6&db=m Molecular basis of reduced Pyridoxine 5'-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder. causal interaction,unassigned 4,0 1.4.3.5 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303608&form=6&db=m Normal Neurodevelopmental Outcomes in PNPO Deficiency: A Case Series and Literature Review. causal interaction,unassigned 4,0 1.4.3.5 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27342130&form=6&db=m The value of plasma vitamin B6 profiles in early onset epileptic encephalopathies. causal interaction,diagnostic usage,unassigned 3,3,0 1.4.3.5 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28985901&form=6&db=m Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.4.3.5 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31616300&form=6&db=m Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency. causal interaction,unassigned 4,0 1.4.3.5 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32788630&form=6&db=m Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy. causal interaction,diagnostic usage,unassigned 4,1,0 1.4.3.5 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32803525&form=6&db=m Nephrotoxicity Profile of Cadmium Revealed by Proteomics in Mouse Kidney. diagnostic usage,unassigned 1,0 1.4.3.5 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30982780&form=6&db=m Pyridoxine 5'-phosphate oxidase is correlated with human breast invasive ductal carcinoma development. causal interaction,ongoing research,unassigned 4,2,0 1.4.3.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3007703&form=6&db=m Azo dye-induced alterations in vitamin B-6 metabolism and in pyridoxal 5'-phosphate-binding proteins in rat liver. diagnostic usage,unassigned 2,0 1.4.3.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6125259&form=6&db=m Vitamin B6 metabolism in liver and liver-derived tumors. diagnostic usage,unassigned 4,0 1.4.3.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6259164&form=6&db=m Vitamin B6 metabolism in Morris hepatomas. causal interaction,diagnostic usage,unassigned 4,3,0 1.4.3.5 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29238081&form=6&db=m Pyridoxine 5'-phosphate oxidase is a novel therapeutic target and regulated by the TGF-? signalling pathway in epithelial ovarian cancer. causal interaction,unassigned 2,0 1.4.3.5 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19356691&form=6&db=m Enhanced pyridoxal 5'-phosphate synthetic enzyme immunoreactivities do not contribute to GABAergic inhibition in the rat hippocampus following pilocarpine-induced status epilepticus. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.4.3.5 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20370816&form=6&db=m Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency. causal interaction,diagnostic usage,unassigned 3,2,0 1.4.3.5 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412262&form=6&db=m Pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency: unique clinical symptoms and non-specific EEG characteristics. causal interaction,unassigned 4,0 1.4.3.5 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21292558&form=6&db=m Electroencephalographic and seizure manifestations of pyridoxal 5'-phosphate-dependent epilepsy. causal interaction,therapeutic application,unassigned 1,1,0 1.4.3.5 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28782931&form=6&db=m An LC-MS/MS-Based Method for the Quantification of Pyridox(am)ine 5'-Phosphate Oxidase Activity in Dried Blood Spots from Patients with Epilepsy. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 1.4.3.5 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28985901&form=6&db=m Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.4.3.5 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31397616&form=6&db=m Further Delineation of Pyridoxine-Responsive Pyridoxine Phosphate Oxidase Deficiency Epilepsy: Report of a New Case and Review of the Literature With Genotype-Phenotype Correlation. causal interaction,therapeutic application,unassigned 4,1,0 1.4.3.5 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31484724&form=6&db=m Allosteric feedback inhibition of pyridoxine 5'-phosphate oxidase from Escherichia coli. causal interaction,unassigned 1,0 1.4.3.5 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33425341&form=6&db=m Vitamin B6-dependent epilepsy due to pyridoxal phosphate-binding protein (PLPBP) defect - First case report from Pakistan and review of literature. causal interaction,diagnostic usage,unassigned 3,2,0 1.4.3.5 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23534755&form=6&db=m Proteomics Analysis of Gastric Epithelial AGS Cells Infected with Epstein-Barr Virus. causal interaction,unassigned 1,0 1.4.3.5 glucose-6-phosphate dehydrogenase (nadp+) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3582603&form=6&db=m Glutathione reductase activity and its relationship to pyridoxine phosphate activity in G6PD deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 1.4.3.5 glucose-6-phosphate dehydrogenase (nadp+) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4019261&form=6&db=m A simple fluorimetric assay for pyridoxamine phosphate oxidase in erythrocyte haemolysates: effects of riboflavin supplementation and of glucose 6-phosphate dehydrogenase deficiency. ongoing research,unassigned 1,0 1.4.3.5 Glucosephosphate Dehydrogenase Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3582603&form=6&db=m Glutathione reductase activity and its relationship to pyridoxine phosphate activity in G6PD deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 1.4.3.5 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14697241&form=6&db=m Pyridoxine 5'-phosphate oxidase is a candidate gene responsible for hypertension in Dahl-S rats. causal interaction,unassigned 4,0 1.4.3.5 Hypoxia-Ischemia, Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303608&form=6&db=m Normal Neurodevelopmental Outcomes in PNPO Deficiency: A Case Series and Literature Review. causal interaction,unassigned 4,0 1.4.3.5 l-aminoadipate-semialdehyde dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18062169&form=6&db=m Vitamin B6 related epilepsy during childhood. causal interaction,unassigned 4,0 1.4.3.5 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12542535&form=6&db=m Cutaneous metabolism of vitamin B-6. causal interaction,unassigned 1,0 1.4.3.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6259164&form=6&db=m Vitamin B6 metabolism in Morris hepatomas. causal interaction,diagnostic usage,unassigned 4,3,0 1.4.3.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12542535&form=6&db=m Cutaneous metabolism of vitamin B-6. causal interaction,unassigned 1,0 1.4.3.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29238081&form=6&db=m Pyridoxine 5'-phosphate oxidase is a novel therapeutic target and regulated by the TGF-? signalling pathway in epithelial ovarian cancer. causal interaction,unassigned 2,0 1.4.3.5 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32788630&form=6&db=m Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy. causal interaction,diagnostic usage,unassigned 4,1,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18024216&form=6&db=m A new fatal case of pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency. causal interaction,therapeutic application,unassigned 3,3,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18062169&form=6&db=m Vitamin B6 related epilepsy during childhood. causal interaction,unassigned 4,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20370816&form=6&db=m Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency. causal interaction,diagnostic usage,unassigned 3,2,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412262&form=6&db=m Pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency: unique clinical symptoms and non-specific EEG characteristics. causal interaction,unassigned 4,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23419474&form=6&db=m Seizures with decreased levels of pyridoxal phosphate in cerebrospinal fluid. causal interaction,unassigned 4,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24645144&form=6&db=m Epilepsy due to PNPO mutations: genotype, environment and treatment affect presentation and outcome. causal interaction,therapeutic application,unassigned 4,4,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24739647&form=6&db=m A nutritional conditional lethal mutant due to pyridoxine 5'-phosphate oxidase deficiency in Drosophila melanogaster. causal interaction,unassigned 2,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25256445&form=6&db=m Cirrhosis associated with pyridoxal 5'-phosphate treatment of pyridoxamine 5'-phosphate oxidase deficiency. causal interaction,therapeutic application,unassigned 4,1,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303608&form=6&db=m Normal Neurodevelopmental Outcomes in PNPO Deficiency: A Case Series and Literature Review. causal interaction,unassigned 4,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28985901&form=6&db=m Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31397616&form=6&db=m Further Delineation of Pyridoxine-Responsive Pyridoxine Phosphate Oxidase Deficiency Epilepsy: Report of a New Case and Review of the Literature With Genotype-Phenotype Correlation. causal interaction,therapeutic application,unassigned 4,1,0 1.4.3.5 pyridoxal 5'-phosphate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32788630&form=6&db=m Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy. causal interaction,diagnostic usage,unassigned 4,1,0 1.4.3.5 Riboflavin Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4019261&form=6&db=m A simple fluorimetric assay for pyridoxamine phosphate oxidase in erythrocyte haemolysates: effects of riboflavin supplementation and of glucose 6-phosphate dehydrogenase deficiency. ongoing research,unassigned 1,0 1.4.3.5 Riboflavin Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7420202&form=6&db=m Effect of strain, sex and dietary riboflavin on pyridoxamine (pyridoxine) 5'-phosphate oxidase activity in rat tissues. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12111839&form=6&db=m Chronological changes in pyridoxine-5'-phosphate oxidase immunoreactivity in the seizure-sensitive gerbil hippocampus. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,2 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14568555&form=6&db=m Vigabatrin inhibits pyridoxine-5'-phosphate oxidase, not pyridoxal kinase in the hippocampus of seizure prone gerbils. ongoing research,therapeutic application,unassigned 3,1,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15772097&form=6&db=m Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase. causal interaction,therapeutic application,unassigned 3,4,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16538088&form=6&db=m Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment. causal interaction,unassigned 3,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18485777&form=6&db=m PNPO deficiency: an under diagnosed inborn error of pyridoxine metabolism. causal interaction,unassigned 4,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19356691&form=6&db=m Enhanced pyridoxal 5'-phosphate synthetic enzyme immunoreactivities do not contribute to GABAergic inhibition in the rat hippocampus following pilocarpine-induced status epilepticus. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20184790&form=6&db=m Neonatal vitamin-responsive epileptic encephalopathies. causal interaction,unassigned 4,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20370816&form=6&db=m Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency. causal interaction,diagnostic usage,unassigned 3,2,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21292558&form=6&db=m Electroencephalographic and seizure manifestations of pyridoxal 5'-phosphate-dependent epilepsy. causal interaction,therapeutic application,unassigned 1,1,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23419474&form=6&db=m Seizures with decreased levels of pyridoxal phosphate in cerebrospinal fluid. causal interaction,unassigned 4,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24645144&form=6&db=m Epilepsy due to PNPO mutations: genotype, environment and treatment affect presentation and outcome. causal interaction,therapeutic application,unassigned 4,4,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31616300&form=6&db=m Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency. causal interaction,unassigned 4,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31759955&form=6&db=m Pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency in zebrafish results in fatal seizures and metabolic aberrations. causal interaction,unassigned 4,0 1.4.3.5 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32788630&form=6&db=m Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy. causal interaction,diagnostic usage,unassigned 4,1,0 1.4.3.5 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19356691&form=6&db=m Enhanced pyridoxal 5'-phosphate synthetic enzyme immunoreactivities do not contribute to GABAergic inhibition in the rat hippocampus following pilocarpine-induced status epilepticus. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 1.4.3.5 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18647502&form=6&db=m Identification of non-Alzheimer's disease tauopathies-related proteins by proteomic analysis. unassigned - 1.4.3.5 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16374842&form=6&db=m Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis. ongoing research,unassigned 3,0 1.4.3.5 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16880544&form=6&db=m The molecular structure of Rv2074, a probable pyridoxine 5'-phosphate oxidase from Mycobacterium tuberculosis, at 1.6 angstroms resolution. ongoing research,unassigned 1,0 1.4.3.5 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18453720&form=6&db=m Cloning, expression, purification, crystallization and preliminary X-ray studies of a pyridoxine 5'-phosphate oxidase from Mycobacterium smegmatis. unassigned - 1.4.3.5 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22110704&form=6&db=m Rv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificity. causal interaction,therapeutic application,unassigned 1,1,0 1.4.3.5 Vitamin B 6 Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=482285&form=6&db=m Pyridoxamine (pyridoxine) 5'-phosphate oxidase activity in rat tissues during development of riboflavin or pyridoxine deficiency. unassigned -