2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4258782&form=6&db=m Succinyl-CoA: 3-ketoacid CoA-transferase deficiency. A cause for ketoacidosis in infancy. causal interaction,unassigned 4,0 2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7474899&form=6&db=m A new Japanese case of succinyl-CoA: 3-ketoacid CoA-transferase deficiency. causal interaction,unassigned 4,0 2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9590068&form=6&db=m [Succinyl-CoA: 3-ketoacid CoA transferase deficiency] causal interaction,unassigned 3,0 2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11528975&form=6&db=m [Succinyl-CoA: 3-ketoacid CoA transferase deficiency] causal interaction,unassigned 3,0 2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11757586&form=6&db=m Neonatal hypoglycaemia in severe succinyl-CoA: 3-oxoacid CoA-transferase deficiency. causal interaction,unassigned 4,0 2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19450972&form=6&db=m Management and communication problems in a patient with succinyl-CoA transferase deficiency in pregnancy and labour. causal interaction,unassigned 4,0 2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23233542&form=6&db=m Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation. causal interaction,unassigned 3,0 2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695376&form=6&db=m Heterozygous carriers of succinyl-CoA:3-oxoacid CoA transferase deficiency can develop severe ketoacidosis. causal interaction,therapeutic application,unassigned 4,1,0 2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30799594&form=6&db=m A Rare Cause of Life-Threatening Ketoacidosis: Novel Compound Heterozygous OXCT1 Mutations Causing Succinyl-CoA:3-Ketoacid CoA Transferase Deficiency. causal interaction,unassigned 4,0 2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31073471&form=6&db=m A Case of Succinyl-CoA:3-Oxoacid CoA Transferase Deficiency Presenting with Severe Acidosis in a 14-Month-Old Female: Evidence for Pathogenicity of a Point Mutation in the OXCT1 Gene. causal interaction,unassigned 4,0 2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31216074&form=6&db=m Rare cause of high anion gap metabolic acidosis in an infant: Succinyl-CoA:3-ketoacid transferase deficiency. causal interaction,unassigned 4,0 2.8.3.5 3-oxoacid coa-transferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33596448&form=6&db=m Succinyl-CoA:3-oxoacid coenzyme A transferase (SCOT) deficiency: A rare and potentially fatal metabolic disease. causal interaction,unassigned 4,0 2.8.3.5 acetyl-coa c-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18777091&form=6&db=m Influence of ketone bodies on oxidative stress parameters in brain of developing rats in vitro. causal interaction,ongoing research,unassigned 1,2,0 2.8.3.5 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28488182&form=6&db=m Successful Management of Pregnancies in Patients with Inherited Disorders of Ketone Body Metabolism. causal interaction,unassigned 4,0 2.8.3.5 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31073471&form=6&db=m A Case of Succinyl-CoA:3-Oxoacid CoA Transferase Deficiency Presenting with Severe Acidosis in a 14-Month-Old Female: Evidence for Pathogenicity of a Point Mutation in the OXCT1 Gene. causal interaction,unassigned 4,0 2.8.3.5 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31216074&form=6&db=m Rare cause of high anion gap metabolic acidosis in an infant: Succinyl-CoA:3-ketoacid transferase deficiency. causal interaction,unassigned 4,0 2.8.3.5 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17313687&form=6&db=m The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. unassigned - 2.8.3.5 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29108233&form=6&db=m Mitoketoscins: Novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs). unassigned - 2.8.3.5 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33281976&form=6&db=m ?-hydroxybutyrate does not alter the effects of glucose deprivation on breast cancer cells. causal interaction,diagnostic usage,unassigned 4,3,0 2.8.3.5 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28684065&form=6&db=m The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.8.3.5 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29108233&form=6&db=m Mitoketoscins: Novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs). unassigned - 2.8.3.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=167950&form=6&db=m Acetoacetate coenzyme A transferase activity in rat hepatomas. causal interaction,ongoing research,unassigned 3,2,0 2.8.3.5 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2393855&form=6&db=m Regulation of succinyl coenzyme A:acetoacetyl coenzyme A transferase in rat hepatoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.8.3.5 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2861842&form=6&db=m Failure of systemic ketosis to control cachexia and the growth rate of the Walker 256 carcinosarcoma in rats. unassigned - 2.8.3.5 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33729711&form=6&db=m Physiological activity of E. coli engineered to produce butyric acid. ongoing research,unassigned 3,0 2.8.3.5 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16957230&form=6&db=m Characterization of (R)-2-hydroxyisocaproate dehydrogenase and a family III coenzyme A transferase involved in reduction of L-leucine to isocaproate by Clostridium difficile. causal interaction,unassigned 1,0 2.8.3.5 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32750298&form=6&db=m Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,1 2.8.3.5 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15774485&form=6&db=m Physical training reverses defect in 3-ketoacid CoA-transferase activity in skeletal muscle of diabetic rats. diagnostic usage,therapeutic application,unassigned 2,1,0 2.8.3.5 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20460097&form=6&db=m Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells. ongoing research,unassigned 4,0 2.8.3.5 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32750298&form=6&db=m Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,1 2.8.3.5 Diabetic Ketoacidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1838977&form=6&db=m Ketone body utilization and its metabolic effect in resting muscles of normal and streptozotocin-diabetic rats. unassigned - 2.8.3.5 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16765626&form=6&db=m A 6-bp deletion at the splice donor site of the first intron resulted in aberrant splicing using a cryptic splice site within exon 1 in a patient with succinyl-CoA: 3-Ketoacid CoA transferase (SCOT) deficiency. causal interaction,unassigned 3,0 2.8.3.5 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6118869&form=6&db=m Ketone-body metabolism in glioma and neuroblastoma cells. causal interaction,therapeutic application,unassigned 4,1,0 2.8.3.5 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6594997&form=6&db=m Turnover of succinyl-CoA:3-oxoacid CoA-transferase in glioma and neuroblastoma cells. Specific influence of acetoacetate in neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.8.3.5 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33832517&form=6&db=m Novel LncRNA OXCT1-AS1 indicates poor prognosis and contributes to tumorigenesis by regulating miR-195/CDC25A axis in glioblastoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.8.3.5 glycoprotein-fucosylgalactoside alpha-n-acetylgalactosaminyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33596448&form=6&db=m Succinyl-CoA:3-oxoacid coenzyme A transferase (SCOT) deficiency: A rare and potentially fatal metabolic disease. causal interaction,unassigned 4,0 2.8.3.5 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32750298&form=6&db=m Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,1 2.8.3.5 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1782008&form=6&db=m Differential action of thyroid hormones on the activity of certain enzymes in rat kidney and brain. causal interaction,unassigned 1,0 2.8.3.5 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3422549&form=6&db=m Ketone-body metabolism in hyperthyroid rats: reduced activity of D-3-hydroxybutyrate dehydrogenase in both liver and heart and of succinyl-coenzyme A: 3-oxoacid coenzyme A-transferase in heart. therapeutic application,unassigned 1,0 2.8.3.5 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23233542&form=6&db=m Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation. causal interaction,unassigned 3,0 2.8.3.5 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23689508&form=6&db=m Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth. causal interaction,unassigned 1,0 2.8.3.5 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28488182&form=6&db=m Successful Management of Pregnancies in Patients with Inherited Disorders of Ketone Body Metabolism. causal interaction,unassigned 4,0 2.8.3.5 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15139973&form=6&db=m Ketone bodies could support the motility but not the acrosome reaction of mouse sperm. causal interaction,unassigned 3,0 2.8.3.5 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20460097&form=6&db=m Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells. ongoing research,unassigned 4,0 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4258782&form=6&db=m Succinyl-CoA: 3-ketoacid CoA-transferase deficiency. A cause for ketoacidosis in infancy. causal interaction,unassigned 4,0 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9083111&form=6&db=m Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases. unassigned - 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11757586&form=6&db=m Neonatal hypoglycaemia in severe succinyl-CoA: 3-oxoacid CoA-transferase deficiency. causal interaction,unassigned 4,0 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12463743&form=6&db=m Structure of the mammalian CoA transferase from pig heart. causal interaction,unassigned 3,0 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15496607&form=6&db=m Patients homozygous for the T435N mutation of succinyl-CoA:3-ketoacid CoA Transferase (SCOT) do not show permanent ketosis. diagnostic usage,unassigned 1,0 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17706444&form=6&db=m Identification and characterization of a temperature-sensitive R268H mutation in the human succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene. unassigned - 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19450972&form=6&db=m Management and communication problems in a patient with succinyl-CoA transferase deficiency in pregnancy and labour. causal interaction,unassigned 4,0 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21296660&form=6&db=m Clinical and molecular characterization of five patients with succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency. unassigned - 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23420214&form=6&db=m A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency. unassigned - 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25559898&form=6&db=m Inborn errors of ketone body utilization. causal interaction,unassigned 4,0 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695376&form=6&db=m Heterozygous carriers of succinyl-CoA:3-oxoacid CoA transferase deficiency can develop severe ketoacidosis. causal interaction,therapeutic application,unassigned 4,1,0 2.8.3.5 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30799594&form=6&db=m A Rare Cause of Life-Threatening Ketoacidosis: Novel Compound Heterozygous OXCT1 Mutations Causing Succinyl-CoA:3-Ketoacid CoA Transferase Deficiency. causal interaction,unassigned 4,0 2.8.3.5 Liver Neoplasms, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=187322&form=6&db=m Subcellular localization of acetoacetate coenzyme A transferase in rat hepatomas. ongoing research,unassigned 3,0 2.8.3.5 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29504848&form=6&db=m Signalling pathways identified in salivary glands from primary Sjögren's syndrome patients reveal enhanced adipose tissue development. unassigned - 2.8.3.5 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9083111&form=6&db=m Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases. unassigned - 2.8.3.5 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33596448&form=6&db=m Succinyl-CoA:3-oxoacid coenzyme A transferase (SCOT) deficiency: A rare and potentially fatal metabolic disease. causal interaction,unassigned 4,0 2.8.3.5 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29108233&form=6&db=m Mitoketoscins: Novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs). unassigned - 2.8.3.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=167950&form=6&db=m Acetoacetate coenzyme A transferase activity in rat hepatomas. causal interaction,ongoing research,unassigned 3,2,0 2.8.3.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3778804&form=6&db=m Metabolic substrate utilization by a tumour cell line which induces cachexia in vivo. causal interaction,diagnostic usage,unassigned 1,2,0 2.8.3.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6147189&form=6&db=m Role of acetoacetyl-CoA synthetase in acetoacetate utilization by tumor cells. causal interaction,ongoing research,unassigned 4,3,0 2.8.3.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17313687&form=6&db=m The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. unassigned - 2.8.3.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25806103&form=6&db=m Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature. unassigned - 2.8.3.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28684065&form=6&db=m The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.8.3.5 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29414764&form=6&db=m Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo. diagnostic usage,ongoing research,unassigned 3,4,0 2.8.3.5 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6118869&form=6&db=m Ketone-body metabolism in glioma and neuroblastoma cells. causal interaction,therapeutic application,unassigned 4,1,0 2.8.3.5 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6594997&form=6&db=m Turnover of succinyl-CoA:3-oxoacid CoA-transferase in glioma and neuroblastoma cells. Specific influence of acetoacetate in neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.8.3.5 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434981&form=6&db=m 3-Oxoacid CoA transferase 1 as a therapeutic target gene for cisplatin-resistant ovarian cancer. diagnostic usage,therapeutic application,unassigned 1,3,0 2.8.3.5 Phenylketonurias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28820737&form=6&db=m When one disease is not enough: succinyl-CoA: 3-oxoacid coenzyme A transferase (SCOT) deficiency due to a novel mutation in OXCT1 in an infant with known phenylketonuria. causal interaction,unassigned 3,0 2.8.3.5 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24361452&form=6&db=m Ketone body metabolism and sleep homeostasis in mice. unassigned - 2.8.3.5 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3741427&form=6&db=m Activities of some key enzymes of carbohydrate, ketone body, adenosine and glutamine metabolism in liver, and brown and white adipose tissues of the rat. therapeutic application,unassigned 1,0 2.8.3.5 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15330163&form=6&db=m Growth-inhibitory effects of the ketone body, monoacetoacetin, on human gastric cancer cells with succinyl-CoA: 3-oxoacid CoA-transferase (SCOT) deficiency. causal interaction,ongoing research,unassigned 1,1,0 2.8.3.5 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33357314&form=6&db=m [Analysis of Gene Variation in Thymoma by Microarray]. unassigned -