1.14.11.51	C118A	m6A demethylase activity similar to wild-type, about 25% decrease in apurinic/apyrimidinic lyase activity	764135	
1.14.11.51	C118A/C129A	about 50% decrease in m6A demethylase activity, about 20% decrease in apurinic/apyrimidinic lyase activity	764135	
1.14.11.51	C129A	about 90% decrease in m6A demethylase activity, about 30% decrease in apurinic/apyrimidinic lyase activity	764135	
1.14.11.51	D186A	inactive	742235	
1.14.11.51	D233A	no residual m6A demethylase activity, about 30% decrease in apurinic/apyrimidinic lyase activity	764135	
1.14.11.51	D233A	reduced activity of the recombinant mutant protein	736883	
1.14.11.51	D233A	residue plays an important role in substrate recognition and catalysis	764114	
1.14.11.51	H113A/C118A/C129A/H134A	no residual m6A demethylase activity, about 55% decrease in apurinic/apyrimidinic lyase activity	764135	
1.14.11.51	H231A	no residual m6A demethylase activity, about 20% decrease in apurinic/apyrimidinic lyase activity	764135	
1.14.11.51	H231A	residue plays an important role in substrate recognition and catalysis	764114